DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FASN2 and fasn

DIOPT Version :9

Sequence 1:	NP_001259986.1	Gene:	FASN2 / 117361	FlyBaseID:	FBgn0042627	Length:	2410	Species:	Drosophila melanogaster
Sequence 2:	XP_009305081.1	Gene:	fasn / 559001	ZFINID:	ZDB-GENE-030131-7802	Length:	2511	Species:	Danio rerio

Alignment Length:	2526	Identity:	1090/2526 - (43%)
Similarity:	1564/2526 - (61%)	Gaps:	191/2526 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DIVISGLSGKLPESSNIEEFKYNLLNGIDMVTDEPRRWEAGIYGLPERMAKMKDSDLEKFDDKFF 82
            ||||:|:||:||||:|:|||..||.||:||||::.|||:.|:||||.|..|:|  ::::||..||
Zfish     3 DIVIAGISGRLPESNNLEEFWQNLFNGVDMVTEDDRRWKPGLYGLPRRNGKLK--EIDRFDAAFF 65

  Fly    83 SVHQKQAELMDPCMRMLLELTHEAIIDAGINPVQLRGSRTGVYIGLSFVETEHEIPNMEPSSING 147
            .||.|||..|||.:|::||:::|||:|.|||||.:|||:||||||:|..|. .|..:.:|..:.|
Zfish    66 GVHPKQAHTMDPQLRLMLEISYEAIVDGGINPVSMRGSKTGVYIGVSGSEA-GEAFSKDPEELLG 129

  Fly   148 YCLTGCARAMFANRISYTFDFKGPSFIVDTACSSSLVALNHAFADMRAGRCDYALVAGVNLILKP 212
            |.:|||.|||||||:||.|||.|||..:||||||||:||.:||..:|.|:||.||:.||||:|||
Zfish   130 YSMTGCQRAMFANRLSYFFDFNGPSTAIDTACSSSLLALENAFNAIRHGKCDAALIGGVNLLLKP 194

  Fly   213 IFALQFLRLGIVSHDGSCKTFDAAANGYARADTCAVVLLQRRKEAKRVYASILNVRTNTDGFKEQ 277
            ..::||::||::|.:|:||:|||:.|||.|::....|||.::..|||:||::||...||||:|||
Zfish   195 NTSVQFMKLGMLSPEGTCKSFDASGNGYCRSEAAVAVLLTKKSMAKRIYATVLNAGNNTDGYKEQ 259

  Fly   278 GVTFPDGRMQQALLEETYSEIGLNPDEVVYVEAHGSGTPVGDDQEANMLSNFFCRPSRSTPLLIG 342
            |||||.|.|||.|:...|.|..::|::|.|:||||:||.|||.||.|.:.:.||:..|. |||||
Zfish   260 GVTFPSGEMQQRLVRSLYQEANISPEQVEYIEAHGTGTKVGDPQEVNGIVSVFCQSQRD-PLLIG 323

  Fly   343 SVKSNMGHAEPASGVSALAKMIIAMEEGIIPKNLHYRTPNPSVPALVEGKLKVVDRNLPWQGGIV 407
            |.||||||.|||||::||||:::::|.|:...|:|:..|||.:|||.:|:|.||.:..|.:||||
Zfish   324 STKSNMGHPEPASGLAALAKVVLSLEHGVWAPNVHFNEPNPDIPALTDGRLCVVSKPTPVRGGIV 388

  Fly   408 GLNSFGFGGANAHVVLKSHTKAKEPKACPKAGEAEQSLSLVTCSGRTEDAVNQLLKVATEQRHDQ 472
            |:|||||||:|.||:|..|......|.     .|.....|:..|||||:||..|...|.:.:.:.
Zfish   389 GINSFGFGGSNVHVILSPHVSDSSDKT-----PAPSVPRLLQASGRTEEAVTALFSNAQQHQENS 448

  Fly   473 ELLTLINDIHSHPIPLHPFRGYAVLGTSGCVKEEVLPYEEEERPIWFVYAGMGSQWARMAKDLMQ 537
            ..|:|:||:...|....|:|||.::|..|.: .||...:...||:|::.:|||:|||.|.:.|||
Zfish   449 SYLSLLNDVSGVPTAGMPYRGYTLIGAQGEL-TEVQQTQPTPRPLWYICSGMGTQWAGMGQSLMQ 512

  Fly   538 LEVFRNSIQHCAEVLAQVDFDLIDVLTRSTERTFDNMLYSFVSVSAVQVALTDLLRVLDIRPDGI 602
            |..||.||:.....|......:..:|..:.|.||::.:::||.::|:|||..|:||.:.:.|:||
Zfish   513 LSEFRESIKRSDIALKDTGLCVSRLLMEADESTFEDTVHAFVGLAAIQVAQIDMLRKMGLEPNGI 577

  Fly   603 IGHSAGELGAAYMDGCLTAEQTVLAAYWRGRSVLDTPDLPRGKMAAVGLSWEQIGSQIPKDCYPV 667
            :|||.|||...|.||.|:..:.:||||||||.:.:. :||.|.||||||:||:..:|.|:...|.
Zfish   578 VGHSVGELACGYADGSLSHSEAILAAYWRGRCIKEA-NLPPGGMAAVGLTWEECKAQCPQGVVPA 641

  Fly   668 CHNSDDNCTVSGPPSSMDAMIEDLTAKGIFVREVGSGGYAFHSPYIEGAAPMLRRSLERLITEPK 732
            |||::|..|:|||..|:...:..|...|:|.:||.|.|.||||.|:...||.|..:|:::|..|:
Zfish   642 CHNAEDTVTISGPQDSVSKFVAQLKESGVFAKEVRSAGVAFHSYYMASIAPALLSALQKVIKSPR 706

  Fly   733 KKSIRWLSTSVKEAEWDSEKNHLASAGYFINNLISPVLFHQAVKRIPQNALIVEIAPHGLFRAIL 797
            .::.||:|||:.:::|:|.....:||.|.:|||:|||||.:.:..:|.||::||||||.|.:|||
Zfish   707 PRTARWISTSIPQSDWESPLALYSSAEYHVNNLVSPVLFQEGLNHVPDNAVVVEIAPHALLQAIL 771

  Fly   798 -RSLSPQISYVSLMQRGHANNFEFLLSQLGRLYAAGGQPQILKISPSIPYPVSRGTPMLGSLVGW 861
             |||.|..|.:.||:||||||.||.||.:|::|..|......|:.|::.|||.||||::...:.|
Zfish   772 KRSLKPTCSILPLMKRGHANNLEFFLSHVGKVYMNGINVDSNKLYPAVKYPVPRGTPLISPYIQW 836

  Fly   862 DHTQKWNYPK---FKGGRQAGQLSV---ELDLGKEE-NVYLAGHTIDGRVLFPATGYMTLAWMSL 919
            ||:|.|:.||   |..| ..|..|.   .:|:..|. :.|:.||.||||||:|||||:.|||.:|
Zfish   837 DHSQSWDVPKVEDFPAG-SGGSTSATVYNIDMNPESPDYYMIGHCIDGRVLYPATGYLVLAWRTL 900

  Fly   920 AQQQGLDYLRTPVLFEDVVFHRATILSVGTVVKLTLNFFPGSSSFEICEGTSLVTSGKIRLVSNV 984
            .:..|.....|||.||||..||||||.....|:|.:...|.::.||:.|..:|..|||:.::.:.
Zfish   901 MRSLGTVMDHTPVTFEDVTIHRATILPKTGSVQLEVRLMPATNRFEVSENGNLAVSGKVSVLEDS 965

  Fly   985 QQEQLQLSSLPGIAGSN-----KLSTKDIYKELRLRGYDYTGVFQGILESDISAVTGQLQWADNW 1044
            ..:.........|...|     :|.:.|||||||||||||...|||||||:.:..:|:|.|..||
Zfish   966 GLDAFHAELNKPITADNEDPKLRLKSGDIYKELRLRGYDYGKTFQGILESNNAGDSGKLHWTGNW 1030

  Fly  1045 ISFMDTMLQFRILSNDIRELYVPTGIERALIDPLKHLELAKKH---QQKLTVNWHRNISVVKCGG 1106
            ::|:|||||..::....|.|.:||.|....:||..|.|....:   |:.:.|..:|.:..:..||
Zfish  1031 VTFLDTMLQMIVVGLPGRSLRLPTRIRSVCVDPKLHEERVNDYEGDQKAVNVFVNRCLDNITAGG 1095

  Fly  1107 VEIHKMKTAQTQRRSGGQSPPSLERYRFWPHSQ----HLGQREEQEKSRSTALAVAIQLIIENSG 1167
            |:|..:......||...|:||:||.:.|.|:..    ...::...:......|...:|..:...|
Zfish  1096 VQICGLHATAAPRRQQQQTPPTLEEFVFVPYEDADCLRTNEKLADQLRHCKGLVQRLQRKLAKQG 1160

  Fly  1168 GAVKLKGVELAGSRSTLDALSAVQLLELIE---------------------------REPILVG- 1204
            ..:.:.|:|.|.....::|.:...||.|:.                           ::|:|.|
Zfish  1161 VKISIPGLEGASEGQLIEAEAEKGLLRLLSVLCGLELNGNLRSELEQTVQKERDCLLQDPLLNGL 1225

  Fly  1205 ----------DMAVVTSSSNESELGEQLKEHGIRVIVKDIKAGAVEQQCHFVYSVNMLA------ 1253
                      |.|:..|:..:.::.|.|...| ||..:.:....::......|:.:.::
Zfish  1226 LDSQALRHCLDTALENSTPGKFKVLEALAADG-RVFSQAVSLLNIQPMLRLDYTASDISADQLSA 1289

  Fly  1254 -QNSVK-----------------------DLQHC----------------LDSLKSDSGFLLL-- 1276
             |:|::                       ||..|                |.|...:.||:||
Zfish  1290 QQSSLEEQGISTAQWDPLQGPVTGGLDGADLVVCNCAVGSATNPALLIENLTSAAREGGFILLHT 1354

  Fly  1277 --------EEAA---SRYNIIG-------KEKLNK--LKLVSVLEQFFGTDRVLVLVRKLSKVQS 1321
                    |..|   |:.|..|       :|...|  |.:|.:.:.::|:  .|.|.|:..:...
Zfish  1355 LLRGDTLGETVAFLTSQNNRKGLLTQTEWEELFQKASLNVVMLRKSYYGS--ALFLCRRSQQSSQ 1417

  Fly  1322 SQALTLHLTNKQFKWVNELKNSIAKAQAEEKNLYLVAQGEPNSGALGLMNCLKREAGGHFLRLYL 1386
            .|.:.:.:....:|||..||:::  |::.:..::|:|. :.::|.:|::|||::|.||:.:|...
Zfish  1418 KQPIHIFVDPTDYKWVETLKSTL--AESSDIPVWLIAT-KGHNGVVGMVNCLRQEPGGNRIRCTF 1479

  Fly  1387 I--LDEG--VPQFSLDDPFYAAQLAKDLVVNVYRNGSWGSYRHLKMESRPPMLPVEQAYVNTLVK 1447
            :  |.:|  ||....::....|.|.||||:||:|:|.||.:||..:.........||||||.|.:
Zfish  1480 VSNLSKGAAVPSLLPNEKVMKALLKKDLVMNVHRDGLWGVFRHQLLTQDLSEELTEQAYVNVLTR 1544

  Fly  1448 GDLSSLRWIESP-----RSSPIQSQLEPCTVYYAPLNFRDVMLASGKLGVDALPGDLAYQDCVLG 1507
            |||||||||.||     .|||   .::.|.|||:.|||||:|||:|||..||:|||:|.|.|:||
Zfish  1545 GDLSSLRWIASPLRHFVASSP---NVQLCRVYYSSLNFRDIMLATGKLPPDAIPGDVALQQCMLG 1606

  Fly  1508 LEFAGRDSCGRRVMAMVTAKSLATNCLANRNLLWEVPSKWTMEQASTVPCVYATVYYALVVRGQM 1572
            :||:|||..|||||.::.||.|||...|::..||:|||.||:|||::||.||||.||:|||||::
Zfish  1607 MEFSGRDPSGRRVMGLLPAKGLATCVDADKRFLWDVPSSWTLEQAASVPVVYATAYYSLVVRGRL 1671

  Fly  1573 KEGERILIHAGSGGVGQAAISVALAHGLTVFTTVGSKEKREFLLKRFPKLKAKNIGNSRDTSFEQ 1637
            :.||.:|||:||||||||||::||:....||||||||||:::|.:|||:|.|::..||||:||||
Zfish  1672 RPGESVLIHSGSGGVGQAAIAIALSMRCRVFTTVGSKEKKQYLQERFPQLTAESFANSRDSSFEQ 1736

  Fly  1638 LIMSETHGNGVELVLNSLSEEKLQASIRCLALNGRFLEIGKFDLSNNTPLGMSVFLKNTSFHGIL 1702
            .:|..|.|.||:||||||:|||||||:||||.:||||||||:||||||||||::||||.:|||||
Zfish  1737 HVMLNTQGKGVDLVLNSLAEEKLQASLRCLARHGRFLEIGKYDLSNNTPLGMALFLKNVAFHGIL 1801

  Fly  1703 LDSVM-EGEEEMQLMVAKLVAEGIKSGAVQPLPTTVFAEQEIEKAFRFMASGKHIGKVVIKVRLE 1766
            ||::. ||..|.: .|:.|:.:||.||.||||.||||...::|:|||:||.|||||||:::||.|
Zfish  1802 LDALFEEGNREWE-EVSDLLKKGISSGVVQPLRTTVFERNQVEEAFRYMAQGKHIGKVLLQVRSE 1865

  Fly  1767 EEQQA--ALPRLRQIQAIPRSYMHPEKSYILVGGLGGFGLELANWLVSRGARFLVLSSRSGVKSG 1829
            |...:  |:..| .|.||.|::.....|||:.|||||||||||.||..||||.|||:||||:::|
Zfish  1866 ESSSSGPAVSAL-SIPAICRTFCPASLSYIITGGLGGFGLELAQWLTERGARKLVLTSRSGIRNG 1929

  Fly  1830 YQALMIRRWHDRGVQVQIDTNDVTTAVGCQRLLEVSNKLALVGGIFNLAAVLRDGLIEDQSPKNF 1894
            |||..:|.|...|:||.:.|:||:|..|.:||:..:.:|..|||||:||.||:||::|:.:|:.|
Zfish  1930 YQAKRVREWQAMGIQVLVSTSDVSTLDGTERLITEACRLGPVGGIFHLAMVLKDGMLENLTPQEF 1994

  Fly  1895 EKVSAPKLLATIHLDKISREICPALEYFVCFSSLSCGRGNMGQTNYGLANSTMERICEQRQEYGY 1959
            .:|:.||...||:||.::|:.||.|:.||.|||:||||||.||:|||.||||||||||||::...
Zfish  1995 IEVNRPKYDGTINLDSVTRQKCPQLQQFVVFSSVSCGRGNAGQSNYGFANSTMERICEQRRQENL 2059

  Fly  1960 PGTAIQWGAIGDTGLIIEHMGNNETVVGGTLPQRMISCLETLDLFLQQPHPVMASMVVAEK---R 2021
            ||.|:|||||||.|:::|.||.|:.|:||||||||.||||.||.||.|..|||:|.|:|||   .
Zfish  2060 PGLAVQWGAIGDVGVVLETMGGNDAVIGGTLPQRMSSCLEVLDRFLCQQRPVMSSFVLAEKVVVT 2124

  Fly  2022 KTEQANRLSLIATIANIMGLRDVKSVSDKTTLFDLGMDSLMSTEIKQTLERHFDLVLSAQEIRQL 2086
            |.|.:.:..|:..:|:|:|:|||.|::...:|.|||:||||..|::|||||.:|:|::.:|||||
Zfish  2125 KGEGSGQKDLVEAVAHILGVRDVNSLNADASLADLGLDSLMGVEVRQTLERDYDIVMAMREIRQL 2189

  Fly  2087 TFSALRQIDAQEPPSASVSSPSASSTLSRIKEEACVEVQPQSDETRKVFAKEVLPQ-EVMVRLRS 2150
            |.:.||::..|       |.....|.:.|...:|.:|    ||.:|.:    |.|. ..|..|..
Zfish  2190 TINKLRELSKQ-------SGGKEESPVKRSGAQALLE----SDLSRML----VNPDGPTMAPLNE 2239

  Fly  2151 KAPVASEDPAVFFLAPIEGFTIAVEALAASLTCPAYGLQCTEQVPLDSIEACAAYYLRQIQKLQP 2215
               |.|.:..:|.:.||||...|...|.|.|:.|.||||||:..|||||::.||||:..::::|.
Zfish  2240 ---VQSAERPLFLVHPIEGSIAAFRTLTAKLSVPCYGLQCTKAAPLDSIQSLAAYYVECVRQVQL 2301

  Fly  2216 LGPYHIVGYSYGCLLAHAIAVALEQRRFGVKVIML-DGAPTMASGYVQ--EAKKQTDDLNRQQSM 2277
            .|||.|.|||:|..:|..:...|:..:..|:.:.| ||:.:..:.|.|  .||......:..::.
Zfish  2302 EGPYRIAGYSFGACVAFEMCSQLQLAKCPVEYLFLFDGSHSYVAAYTQSYRAKLTPGKESEAETE 2366

  Fly  2278 TLAYFGALLADVDYNQVLLQLLDGVQTWPSKLDKLADTL-AGYTQQTREVIKKAACMFKQKLLLS 2341
            .|..|......::||::|..||. :....:::||..|.: :.:...:|:::..||..|..||..:
Zfish  2367 ALCAFIQQFTGIEYNKLLETLLP-LSDLEARVDKAVDLITSSHKNVSRDMLHFAASTFYHKLKAA 2430

  Fly  2342 ESYKGAKQLHSDVVLIK---SAEHNAIMAQDYGLKEICSAQIDMHVVEGTHRTFLK 2394
            :.|....:.|.:|.|::   |:|:...:..||.|.|:|..::.:||:||.|||||:
Zfish  2431 DRYVPTSKYHGNVTLLRAKASSEYGDGLGSDYKLHEVCDGKVSVHVIEGDHRTFLE 2486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FASN2	NP_001259986.1	PksD	15..1043	CDD:225858	491/1037 (47%)
		PKS	18..423	CDD:238429	229/404 (57%)
		KAsynt_C_assoc	381..498	CDD:292814	49/116 (42%)
		Acyl_transf_1	518..835	CDD:298668	143/317 (45%)
		hot_dog	875..1072	CDD:294345	86/205 (42%)
		NADB_Rossmann	1263..>1429	CDD:304358	56/207 (27%)
		PKS_ER	1471..1761	CDD:214840	186/290 (64%)
		enoyl_red	1473..1761	CDD:176179	185/288 (64%)
		KR_1_FAS_SDR_x	<1780..2018	CDD:187657	138/237 (58%)
		PKS_PP	2031..>2083	CDD:214834	24/51 (47%)
		Abhydrolase	2159..2408	CDD:304388	80/243 (33%)
fasn	XP_009305081.1	PksD	1..1014	CDD:225858	485/1022 (47%)
		PKS	2..404	CDD:238429	229/404 (57%)
		KAsynt_C_assoc	362..474	CDD:292814	49/116 (42%)
		Acyl_transf_1	493..810	CDD:279088	143/317 (45%)
		hot_dog	879..1070	CDD:294345	83/190 (44%)
		NADB_Rossmann	1331..>1530	CDD:304358	55/203 (27%)
		PKS_ER	1570..1860	CDD:214840	186/290 (64%)
		enoyl_red	1571..1860	CDD:176179	185/289 (64%)
		KR_1_FAS_SDR_x	<1863..2118	CDD:187657	144/255 (56%)
		PKS_PP	2134..>2186	CDD:214834	24/51 (47%)
		Abhydrolase	2245..2488	CDD:304388	80/243 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	352	1.000	Domainoid score	I968
eggNOG	1	0.900	-	-		E1_COG3321
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2083	1.000	Inparanoid score	I43
OMA	1	1.010	-	-		QHG56071
OrthoDB	1	1.010	-	-		D19161at2759
OrthoFinder	1	1.000	-	-		FOG0001625
OrthoInspector	1	1.000	-	-		otm24450
orthoMCL	1	0.900	-	-		OOG6_100178
Panther	1	1.100	-	-	O	PTHR43775
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4095
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840