Protein Alignment FASN2 and fasn

DIOPT Version :10

• Sequence 1: NP_001259986.1
• Gene: FASN2 / 117361
• FlyBaseID: FBgn0042627
• Length: 2410
• Species: Drosophila melanogaster
• Sequence 2: XP_009305081.1
• Gene: fasn / 559001
• ZFINID: ZDB-GENE-030131-7802
• Length: 2511
• Species: Danio rerio
• Alignment Length: 2526
• Identity: 1090/2526 - (43%)
• Similarity: 1564/2526 - (61%)
• Gaps: 191/2526 - (7%)

  Fly    18 DIVISGLSGKLPESSNIEEFKYNLLNGIDMVTDEPRRWEAGIYGLPERMAKMKDSDLEKFDDKFF 82
            ||||:|:||:||||:|:|||..||.||:||||::.|||:.|:||||.|..|:|  ::::||..||
Zfish     3 DIVIAGISGRLPESNNLEEFWQNLFNGVDMVTEDDRRWKPGLYGLPRRNGKLK--EIDRFDAAFF 65

  Fly    83 SVHQKQAELMDPCMRMLLELTHEAIIDAGINPVQLRGSRTGVYIGLSFVETEHEIPNMEPSSING 147
            .||.|||..|||.:|::||:::|||:|.|||||.:|||:||||||:|..|. .|..:.:|..:.|
Zfish    66 GVHPKQAHTMDPQLRLMLEISYEAIVDGGINPVSMRGSKTGVYIGVSGSEA-GEAFSKDPEELLG 129

  Fly   148 YCLTGCARAMFANRISYTFDFKGPSFIVDTACSSSLVALNHAFADMRAGRCDYALVAGVNLILKP 212
            |.:|||.|||||||:||.|||.|||..:||||||||:||.:||..:|.|:||.||:.||||:|||
Zfish   130 YSMTGCQRAMFANRLSYFFDFNGPSTAIDTACSSSLLALENAFNAIRHGKCDAALIGGVNLLLKP 194

  Fly   213 IFALQFLRLGIVSHDGSCKTFDAAANGYARADTCAVVLLQRRKEAKRVYASILNVRTNTDGFKEQ 277
            ..::||::||::|.:|:||:|||:.|||.|::....|||.::..|||:||::||...||||:|||
Zfish   195 NTSVQFMKLGMLSPEGTCKSFDASGNGYCRSEAAVAVLLTKKSMAKRIYATVLNAGNNTDGYKEQ 259

  Fly   278 GVTFPDGRMQQALLEETYSEIGLNPDEVVYVEAHGSGTPVGDDQEANMLSNFFCRPSRSTPLLIG 342
            |||||.|.|||.|:...|.|..::|::|.|:||||:||.|||.||.|.:.:.||:..|. |||||
Zfish   260 GVTFPSGEMQQRLVRSLYQEANISPEQVEYIEAHGTGTKVGDPQEVNGIVSVFCQSQRD-PLLIG 323

  Fly   343 SVKSNMGHAEPASGVSALAKMIIAMEEGIIPKNLHYRTPNPSVPALVEGKLKVVDRNLPWQGGIV 407
            |.||||||.|||||::||||:::::|.|:...|:|:..|||.:|||.:|:|.||.:..|.:||||
Zfish   324 STKSNMGHPEPASGLAALAKVVLSLEHGVWAPNVHFNEPNPDIPALTDGRLCVVSKPTPVRGGIV 388

  Fly   408 GLNSFGFGGANAHVVLKSHTKAKEPKACPKAGEAEQSLSLVTCSGRTEDAVNQLLKVATEQRHDQ 472
            |:|||||||:|.||:|..|......|.     .|.....|:..|||||:||..|...|.:.:.:.
Zfish   389 GINSFGFGGSNVHVILSPHVSDSSDKT-----PAPSVPRLLQASGRTEEAVTALFSNAQQHQENS 448

  Fly   473 ELLTLINDIHSHPIPLHPFRGYAVLGTSGCVKEEVLPYEEEERPIWFVYAGMGSQWARMAKDLMQ 537
            ..|:|:||:...|....|:|||.::|..|.: .||...:...||:|::.:|||:|||.|.:.|||
Zfish   449 SYLSLLNDVSGVPTAGMPYRGYTLIGAQGEL-TEVQQTQPTPRPLWYICSGMGTQWAGMGQSLMQ 512

  Fly   538 LEVFRNSIQHCAEVLAQVDFDLIDVLTRSTERTFDNMLYSFVSVSAVQVALTDLLRVLDIRPDGI 602
            |..||.||:.....|......:..:|..:.|.||::.:::||.::|:|||..|:||.:.:.|:||
Zfish   513 LSEFRESIKRSDIALKDTGLCVSRLLMEADESTFEDTVHAFVGLAAIQVAQIDMLRKMGLEPNGI 577

  Fly   603 IGHSAGELGAAYMDGCLTAEQTVLAAYWRGRSVLDTPDLPRGKMAAVGLSWEQIGSQIPKDCYPV 667
            :|||.|||...|.||.|:..:.:||||||||.:.:. :||.|.||||||:||:..:|.|:...|.
Zfish   578 VGHSVGELACGYADGSLSHSEAILAAYWRGRCIKEA-NLPPGGMAAVGLTWEECKAQCPQGVVPA 641

  Fly   668 CHNSDDNCTVSGPPSSMDAMIEDLTAKGIFVREVGSGGYAFHSPYIEGAAPMLRRSLERLITEPK 732
            |||::|..|:|||..|:...:..|...|:|.:||.|.|.||||.|:...||.|..:|:::|..|:
Zfish   642 CHNAEDTVTISGPQDSVSKFVAQLKESGVFAKEVRSAGVAFHSYYMASIAPALLSALQKVIKSPR 706

  Fly   733 KKSIRWLSTSVKEAEWDSEKNHLASAGYFINNLISPVLFHQAVKRIPQNALIVEIAPHGLFRAIL 797
            .::.||:|||:.:::|:|.....:||.|.:|||:|||||.:.:..:|.||::||||||.|.:|||
Zfish   707 PRTARWISTSIPQSDWESPLALYSSAEYHVNNLVSPVLFQEGLNHVPDNAVVVEIAPHALLQAIL 771

  Fly   798 -RSLSPQISYVSLMQRGHANNFEFLLSQLGRLYAAGGQPQILKISPSIPYPVSRGTPMLGSLVGW 861
             |||.|..|.:.||:||||||.||.||.:|::|..|......|:.|::.|||.||||::...:.|
Zfish   772 KRSLKPTCSILPLMKRGHANNLEFFLSHVGKVYMNGINVDSNKLYPAVKYPVPRGTPLISPYIQW 836

  Fly   862 DHTQKWNYPK---FKGGRQAGQLSV---ELDLGKEE-NVYLAGHTIDGRVLFPATGYMTLAWMSL 919
            ||:|.|:.||   |..| ..|..|.   .:|:..|. :.|:.||.||||||:|||||:.|||.:|
Zfish   837 DHSQSWDVPKVEDFPAG-SGGSTSATVYNIDMNPESPDYYMIGHCIDGRVLYPATGYLVLAWRTL 900

  Fly   920 AQQQGLDYLRTPVLFEDVVFHRATILSVGTVVKLTLNFFPGSSSFEICEGTSLVTSGKIRLVSNV 984
            .:..|.....|||.||||..||||||.....|:|.:...|.::.||:.|..:|..|||:.::.:.
Zfish   901 MRSLGTVMDHTPVTFEDVTIHRATILPKTGSVQLEVRLMPATNRFEVSENGNLAVSGKVSVLEDS 965

  Fly   985 QQEQLQLSSLPGIAGSN-----KLSTKDIYKELRLRGYDYTGVFQGILESDISAVTGQLQWADNW 1044
            ..:.........|...|     :|.:.|||||||||||||...|||||||:.:..:|:|.|..||
Zfish   966 GLDAFHAELNKPITADNEDPKLRLKSGDIYKELRLRGYDYGKTFQGILESNNAGDSGKLHWTGNW 1030

  Fly  1045 ISFMDTMLQFRILSNDIRELYVPTGIERALIDPLKHLELAKKH---QQKLTVNWHRNISVVKCGG 1106
            ::|:|||||..::....|.|.:||.|....:||..|.|....:   |:.:.|..:|.:..:..||
Zfish  1031 VTFLDTMLQMIVVGLPGRSLRLPTRIRSVCVDPKLHEERVNDYEGDQKAVNVFVNRCLDNITAGG 1095

  Fly  1107 VEIHKMKTAQTQRRSGGQSPPSLERYRFWPHSQ----HLGQREEQEKSRSTALAVAIQLIIENSG 1167
            |:|..:......||...|:||:||.:.|.|:..    ...::...:......|...:|..:...|
Zfish  1096 VQICGLHATAAPRRQQQQTPPTLEEFVFVPYEDADCLRTNEKLADQLRHCKGLVQRLQRKLAKQG 1160

  Fly  1168 GAVKLKGVELAGSRSTLDALSAVQLLELIE---------------------------REPILVG- 1204
            ..:.:.|:|.|.....::|.:...||.|:.                           ::|:|.|
Zfish  1161 VKISIPGLEGASEGQLIEAEAEKGLLRLLSVLCGLELNGNLRSELEQTVQKERDCLLQDPLLNGL 1225

  Fly  1205 ----------DMAVVTSSSNESELGEQLKEHGIRVIVKDIKAGAVEQQCHFVYSVNMLA------ 1253
                      |.|:..|:..:.::.|.|...| ||..:.:....::......|:.:.::
Zfish  1226 LDSQALRHCLDTALENSTPGKFKVLEALAADG-RVFSQAVSLLNIQPMLRLDYTASDISADQLSA 1289

  Fly  1254 -QNSVK-----------------------DLQHC----------------LDSLKSDSGFLLL-- 1276
             |:|::                       ||..|                |.|...:.||:||
Zfish  1290 QQSSLEEQGISTAQWDPLQGPVTGGLDGADLVVCNCAVGSATNPALLIENLTSAAREGGFILLHT 1354

  Fly  1277 --------EEAA---SRYNIIG-------KEKLNK--LKLVSVLEQFFGTDRVLVLVRKLSKVQS 1321
                    |..|   |:.|..|       :|...|  |.:|.:.:.::|:  .|.|.|:..:...
Zfish  1355 LLRGDTLGETVAFLTSQNNRKGLLTQTEWEELFQKASLNVVMLRKSYYGS--ALFLCRRSQQSSQ 1417

  Fly  1322 SQALTLHLTNKQFKWVNELKNSIAKAQAEEKNLYLVAQGEPNSGALGLMNCLKREAGGHFLRLYL 1386
            .|.:.:.:....:|||..||:::  |::.:..::|:|. :.::|.:|::|||::|.||:.:|...
Zfish  1418 KQPIHIFVDPTDYKWVETLKSTL--AESSDIPVWLIAT-KGHNGVVGMVNCLRQEPGGNRIRCTF 1479

  Fly  1387 I--LDEG--VPQFSLDDPFYAAQLAKDLVVNVYRNGSWGSYRHLKMESRPPMLPVEQAYVNTLVK 1447
            :  |.:|  ||....::....|.|.||||:||:|:|.||.:||..:.........||||||.|.:
Zfish  1480 VSNLSKGAAVPSLLPNEKVMKALLKKDLVMNVHRDGLWGVFRHQLLTQDLSEELTEQAYVNVLTR 1544

  Fly  1448 GDLSSLRWIESP-----RSSPIQSQLEPCTVYYAPLNFRDVMLASGKLGVDALPGDLAYQDCVLG 1507
            |||||||||.||     .|||   .::.|.|||:.|||||:|||:|||..||:|||:|.|.|:||
Zfish  1545 GDLSSLRWIASPLRHFVASSP---NVQLCRVYYSSLNFRDIMLATGKLPPDAIPGDVALQQCMLG 1606

  Fly  1508 LEFAGRDSCGRRVMAMVTAKSLATNCLANRNLLWEVPSKWTMEQASTVPCVYATVYYALVVRGQM 1572
            :||:|||..|||||.::.||.|||...|::..||:|||.||:|||::||.||||.||:|||||::
Zfish  1607 MEFSGRDPSGRRVMGLLPAKGLATCVDADKRFLWDVPSSWTLEQAASVPVVYATAYYSLVVRGRL 1671

  Fly  1573 KEGERILIHAGSGGVGQAAISVALAHGLTVFTTVGSKEKREFLLKRFPKLKAKNIGNSRDTSFEQ 1637
            :.||.:|||:||||||||||::||:....||||||||||:::|.:|||:|.|::..||||:||||
Zfish  1672 RPGESVLIHSGSGGVGQAAIAIALSMRCRVFTTVGSKEKKQYLQERFPQLTAESFANSRDSSFEQ 1736

  Fly  1638 LIMSETHGNGVELVLNSLSEEKLQASIRCLALNGRFLEIGKFDLSNNTPLGMSVFLKNTSFHGIL 1702
            .:|..|.|.||:||||||:|||||||:||||.:||||||||:||||||||||::||||.:|||||
Zfish  1737 HVMLNTQGKGVDLVLNSLAEEKLQASLRCLARHGRFLEIGKYDLSNNTPLGMALFLKNVAFHGIL 1801

  Fly  1703 LDSVM-EGEEEMQLMVAKLVAEGIKSGAVQPLPTTVFAEQEIEKAFRFMASGKHIGKVVIKVRLE 1766
            ||::. ||..|.: .|:.|:.:||.||.||||.||||...::|:|||:||.|||||||:::||.|
Zfish  1802 LDALFEEGNREWE-EVSDLLKKGISSGVVQPLRTTVFERNQVEEAFRYMAQGKHIGKVLLQVRSE 1865

  Fly  1767 EEQQA--ALPRLRQIQAIPRSYMHPEKSYILVGGLGGFGLELANWLVSRGARFLVLSSRSGVKSG 1829
            |...:  |:..| .|.||.|::.....|||:.|||||||||||.||..||||.|||:||||:::|
Zfish  1866 ESSSSGPAVSAL-SIPAICRTFCPASLSYIITGGLGGFGLELAQWLTERGARKLVLTSRSGIRNG 1929

  Fly  1830 YQALMIRRWHDRGVQVQIDTNDVTTAVGCQRLLEVSNKLALVGGIFNLAAVLRDGLIEDQSPKNF 1894
            |||..:|.|...|:||.:.|:||:|..|.:||:..:.:|..|||||:||.||:||::|:.:|:.|
Zfish  1930 YQAKRVREWQAMGIQVLVSTSDVSTLDGTERLITEACRLGPVGGIFHLAMVLKDGMLENLTPQEF 1994

  Fly  1895 EKVSAPKLLATIHLDKISREICPALEYFVCFSSLSCGRGNMGQTNYGLANSTMERICEQRQEYGY 1959
            .:|:.||...||:||.::|:.||.|:.||.|||:||||||.||:|||.||||||||||||::...
Zfish  1995 IEVNRPKYDGTINLDSVTRQKCPQLQQFVVFSSVSCGRGNAGQSNYGFANSTMERICEQRRQENL 2059

  Fly  1960 PGTAIQWGAIGDTGLIIEHMGNNETVVGGTLPQRMISCLETLDLFLQQPHPVMASMVVAEK---R 2021
            ||.|:|||||||.|:::|.||.|:.|:||||||||.||||.||.||.|..|||:|.|:|||   .
Zfish  2060 PGLAVQWGAIGDVGVVLETMGGNDAVIGGTLPQRMSSCLEVLDRFLCQQRPVMSSFVLAEKVVVT 2124

  Fly  2022 KTEQANRLSLIATIANIMGLRDVKSVSDKTTLFDLGMDSLMSTEIKQTLERHFDLVLSAQEIRQL 2086
            |.|.:.:..|:..:|:|:|:|||.|::...:|.|||:||||..|::|||||.:|:|::.:|||||
Zfish  2125 KGEGSGQKDLVEAVAHILGVRDVNSLNADASLADLGLDSLMGVEVRQTLERDYDIVMAMREIRQL 2189

  Fly  2087 TFSALRQIDAQEPPSASVSSPSASSTLSRIKEEACVEVQPQSDETRKVFAKEVLPQ-EVMVRLRS 2150
            |.:.||::..|       |.....|.:.|...:|.:|    ||.:|.:    |.|. ..|..|..
Zfish  2190 TINKLRELSKQ-------SGGKEESPVKRSGAQALLE----SDLSRML----VNPDGPTMAPLNE 2239

  Fly  2151 KAPVASEDPAVFFLAPIEGFTIAVEALAASLTCPAYGLQCTEQVPLDSIEACAAYYLRQIQKLQP 2215
               |.|.:..:|.:.||||...|...|.|.|:.|.||||||:..|||||::.||||:..::::|.
Zfish  2240 ---VQSAERPLFLVHPIEGSIAAFRTLTAKLSVPCYGLQCTKAAPLDSIQSLAAYYVECVRQVQL 2301

  Fly  2216 LGPYHIVGYSYGCLLAHAIAVALEQRRFGVKVIML-DGAPTMASGYVQ--EAKKQTDDLNRQQSM 2277
            .|||.|.|||:|..:|..:...|:..:..|:.:.| ||:.:..:.|.|  .||......:..::.
Zfish  2302 EGPYRIAGYSFGACVAFEMCSQLQLAKCPVEYLFLFDGSHSYVAAYTQSYRAKLTPGKESEAETE 2366

  Fly  2278 TLAYFGALLADVDYNQVLLQLLDGVQTWPSKLDKLADTL-AGYTQQTREVIKKAACMFKQKLLLS 2341
            .|..|......::||::|..||. :....:::||..|.: :.:...:|:::..||..|..||..:
Zfish  2367 ALCAFIQQFTGIEYNKLLETLLP-LSDLEARVDKAVDLITSSHKNVSRDMLHFAASTFYHKLKAA 2430

  Fly  2342 ESYKGAKQLHSDVVLIK---SAEHNAIMAQDYGLKEICSAQIDMHVVEGTHRTFLK 2394
            :.|....:.|.:|.|::   |:|:...:..||.|.|:|..::.:||:||.|||||:
Zfish  2431 DRYVPTSKYHGNVTLLRAKASSEYGDGLGSDYKLHEVCDGKVSVHVIEGDHRTFLE 2486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FASN2	NP_001259986.1	PksD	15..>832	CDD:442550	400/814 (49%)
		hot_dog	894..>1072	CDD:469797	81/182 (45%)
		Rossmann-fold NAD(P)(+)-binding proteins	1263..>1429	CDD:473865	56/207 (27%)
		PKS_ER	1471..1761	CDD:214840	186/290 (64%)
		KR_1_FAS_SDR_x	<1780..2018	CDD:187657	138/237 (58%)
		PKS_PP	2031..>2083	CDD:214834	24/51 (47%)
		EntF2	<2159..2409	CDD:442548	80/243 (33%)
fasn	XP_009305081.1	PksD	1..>829	CDD:442550	409/836 (49%)
		hot_dog	873..1112	CDD:469797	94/238 (39%)
		UbiG	<1276..1354	CDD:441829	12/77 (16%)
		Rossmann-fold NAD(P)(+)-binding proteins	1331..>1530	CDD:473865	55/203 (27%)
		PKS_ER	1570..1860	CDD:214840	186/290 (64%)
		KR_1_FAS_SDR_x	<1863..2118	CDD:187657	144/255 (56%)
		PKS_PP	2134..>2186	CDD:214834	24/51 (47%)
		alpha/beta hydrolases	2245..2487	CDD:473884	80/243 (33%)