DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FASN2 and ltb4dh

DIOPT Version :9

Sequence 1:	NP_001259986.1	Gene:	FASN2 / 117361	FlyBaseID:	FBgn0042627	Length:	2410	Species:	Drosophila melanogaster
Sequence 2:	NP_001008100.1	Gene:	ltb4dh / 493462	-ID:	-	Length:	329	Species:	Xenopus tropicalis

Alignment Length:	382	Identity:	78/382 - (20%)
Similarity:	135/382 - (35%)	Gaps:	95/382 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1419 SWGSYRHLKMESRPPMLPVEQAYVNTLVKGDLSSLRWIESPRSSPIQSQLEPCTVYYAPLNFRDV 1483
            ||...||.:...:|....:                          |:::|       .||...:|
Frog     6 SWTMVRHFEGAPQPEDFKL--------------------------IENEL-------PPLKDGEV 37

  Fly  1484 MLASGKLGVDALPGDLAYQDCVLGLEFAGRDSCGRRVMAMVTAKSLA--------------TNCL 1534
            :|.|..|.||  |....|....|.   .|....|.:|..::.:|:.|              |:.:
Frog    38 LLESEFLSVD--PYMRPYSKMKLK---EGDVIMGSQVARVIESKNPAVPVGGYYVAFAGWTTHFI 97

  Fly  1535 ANRNLLWEVPSKWTMEQASTVPCVYA-----TVYYALVVRGQMKEGERILIHAGSGGVGQAAISV 1594
            ::...|..:||.|......::....|     |.|:.|:.....|||:.:|::|.:|.||.....:
Frog    98 SDGQGLAPLPSSWPENLPKSLALGAAGMPGLTAYFGLLELCNPKEGDVVLVNAAAGAVGSLVGQI 162

  Fly  1595 ALAHGLTVFTTVGSKEKREFLLKRFPKLKAKNIG-----NSRDTSFEQLIMSETHGNGVELVLNS 1654
            |...|.......||.:|..||         |.||     |.:..|.....:.:....|.:....:
Frog   163 AKIKGCKAVGCAGSDDKVGFL---------KEIGFDEAFNYKTVSSLAEALKKASPEGYDCYFEN 218

  Fly  1655 LSEEKLQASIRCLALNGRFLEIGKFDLSNNTP------LGMSVFLKNTSFHGILL----DSVMEG 1709
            :..:....:::.:...||....|...|.|::.      :...:..|.....|.|:    |...||
Frog   219 VGGKFADTALQQMKDFGRIAVCGAISLYNDSVPSTGPYIQPYILFKQLRMEGFLVTRWQDRYPEG 283

  Fly  1710 EEEM--QLMVAKL-VAEGIKSGAVQPLPTTVFAEQEIEKAFRFMASGKHIGKVVIKV 1763
            ::::  .::..|| ..|.|.:|.           :.:...|..|..|::|||.:|||
Frog   284 QKQLLQWIIEGKLKYHEHITNGF-----------ENMPAGFMGMLKGENIGKAIIKV 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FASN2	NP_001259986.1	PksD	15..1043	CDD:225858
		PKS	18..423	CDD:238429
		KAsynt_C_assoc	381..498	CDD:292814
		Acyl_transf_1	518..835	CDD:298668
		hot_dog	875..1072	CDD:294345
		NADB_Rossmann	1263..>1429	CDD:304358	4/9 (44%)
		PKS_ER	1471..1761	CDD:214840	68/326 (21%)
		enoyl_red	1473..1761	CDD:176179	68/324 (21%)
		KR_1_FAS_SDR_x	<1780..2018	CDD:187657
		PKS_PP	2031..>2083	CDD:214834
		Abhydrolase	2159..2408	CDD:304388
ltb4dh	NP_001008100.1	leukotriene_B4_DH_like	2..329	CDD:176254	76/380 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1925
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030