DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FASN2 and FASN3

DIOPT Version :9

Sequence 1:NP_001259986.1 Gene:FASN2 / 117361 FlyBaseID:FBgn0042627 Length:2410 Species:Drosophila melanogaster
Sequence 2:NP_001015405.3 Gene:FASN3 / 3355111 FlyBaseID:FBgn0287184 Length:2394 Species:Drosophila melanogaster


Alignment Length:2485 Identity:972/2485 - (39%)
Similarity:1429/2485 - (57%) Gaps:203/2485 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SRKKAQGESAAGEDA-DIVISGLSGKLPESSNIEEFKYNLLNGIDMVTDEPRRWEAGIYGLPERM 66
            ::.|....|....|. ||||||::||.|...||.|::|.|.|.||||.|:.|||......:|:|.
  Fly     4 TKNKKYSRSFPDTDGDDIVISGMAGKFPNCRNITEYQYKLYNKIDMVDDDERRWRHFNPEIPKRS 68

  Fly    67 AKMKDSDLEKFDDKFFSVHQKQAELMDPCMRMLLELTHEAIIDAGINPVQLRGSRTGVYIGLSFV 131
            .|:  .||||||..||.||.|||..|||..|:|:|..:||:||:|:||..||||:||||||....
  Fly    69 GKI--CDLEKFDATFFGVHFKQAHTMDPQTRILIETAYEAVIDSGVNPKSLRGSKTGVYIGSCIS 131

  Fly   132 ETEHEIPNMEPSSINGYCLTGCARAMFANRISYTFDFKGPSFIVDTACSSSLVALNHAFADMRAG 196
            |:| :....|..|..|:.:|||:|||.||||||....:||||::|||||||:.||::||:.:|.|
  Fly   132 ESE-KTWFYEKVSSGGFGITGCSRAMMANRISYCLGLEGPSFLLDTACSSSMYALDNAFSAIRNG 195

  Fly   197 RCDYALVAGVNLILKPIFALQFLRLGIVSHDGSCKTFDAAANGYARADTCAVVLLQRRKEAKRVY 261
            ..|.|::.|.||:|.|...|||.|||:::.||.|:.||..|:||.|::|...:.||::|.|||||
  Fly   196 EIDAAIIGGSNLLLHPFVTLQFARLGVLAPDGFCRPFDKNASGYTRSETINCLFLQKKKHAKRVY 260

  Fly   262 ASILNVRTNTDGFKEQGVTFPDGRMQQALLEETYSEIGLNPDEVVYVEAHGSGTPVGDDQEANML 326
            |||:..:||.||:|.:|:|:|.|.:|:.||::.|.:|...|.::.|:|||.:||.|||.:|...:
  Fly   261 ASIVYSKTNCDGYKPEGITYPSGIVQEKLLDQFYKDIDHKPSDLGYLEAHSTGTVVGDPEECKAI 325

  Fly   327 SNFFCRPSRSTPLLIGSVKSNMGHAEPASGVSALAKMIIAMEEGIIPKNLHYRTPNPSVPALVEG 391
            .|..| ..|..|||:||||||:||:|.|||:.:|.|...|.|.|:|..|:::......:..|.||
  Fly   326 DNVLC-SQREEPLLVGSVKSNVGHSEAASGICSLVKACFAFETGLIAPNINFTEVKQIIAPLAEG 389

  Fly   392 KLKVVDRNLPWQGGIVGLNSFGFGGANAHVVLKSHTKAKEPKACPKAGEAEQSLSLVTCSGRTED 456
            :|.||...:|.....:|:|||||||||||.:||.:.|:|.....|    |:....|:|.:||||:
  Fly   390 RLIVVKDVVPLPKPYIGINSFGFGGANAHALLKGYPKSKNNFGIP----ADDVPRLLTWAGRTEE 450

  Fly   457 AVNQLLKVATEQRHDQELLTLINDIHSHPIPLHPFRGYAVL---GTSGC--VKEEVLPYEEEERP 516
            ||.::.....:...|.|.:.|:.:|....:....|||||:.   ||..|  :.::|..|...:||
  Fly   451 AVEEIFNAVEKNPLDAEFIGLLQNIQEEDVSGMVFRGYAIFAKQGTGPCKLLAKDVQHYTGLQRP 515

  Fly   517 IWFVYAGMGSQWARMAKDLMQLEVFRNSIQHCAEVLAQVDFDLIDVLTRSTERTFDNMLYSFVSV 581
            |.:||:||||||.:|...||.:..||.|::.|.::|.....:||.:||.:....:.|:|.|||.:
  Fly   516 IVWVYSGMGSQWNQMGNSLMIIPRFRESVEICHQILLAKGLNLIHILTSNDPEVYQNILNSFVGI 580

  Fly   582 SAVQVALTDLLRVLDIRPDGIIGHSAGELGAAYMDGCLTAEQTVLAAYWRGRSVLDTPDLPRGKM 646
            :|||:.|||:||.|:|:||.|||||.||||.||.||.|||:|.:||||:|||..:|...: ||.|
  Fly   581 AAVQIGLTDVLRSLNIQPDYIIGHSVGELGCAYADGGLTAQQMILAAYYRGRVSVDLEKI-RGSM 644

  Fly   647 AAVGLSWEQIGSQIPKDCYPVCHNSDDNCTVSGPPSSMDAMIEDLTAKGIFVREVGSGGYAFHSP 711
            |||||.::.:...:||.....|||..|:||:|||...:...:.||..||||.:||.....|:||.
  Fly   645 AAVGLGYKTVLHMLPKSIETACHNGPDSCTISGPVDDVAQFVADLKTKGIFAKEVPCSNIAYHSK 709

  Fly   712 YIEGAAPMLRRSLERLITEPKKKSIRWLSTSVKEAEWDSEKNHLASAGYFINNLISPVLFHQAVK 776
            ||....|.|...:..:|..||.::.:||||||.:.:|:.:|....||.|..|||::.|||.:...
  Fly   710 YISHMGPPLLNYMNEIIPHPKPRTKKWLSTSVPKIDWNKDKAKFCSAEYHTNNLLNSVLFDETFS 774

  Fly   777 RIPQNALIVEIAPHGLFRAILRSLSPQISYVSLMQRGHANNFEFLLSQLGRLYAAGGQPQILKIS 841
            .||:|:|.:|:|||||..|||:...|...::.|..||:.||..|.||.||::|..|.......:.
  Fly   775 LIPKNSLTIEVAPHGLLGAILKRSMPSGVHIPLTNRGNQNNASFFLSALGKIYLNGVLLPAANLY 839

  Fly   842 PSIPYPVSRGTPMLGSLVGWDHTQKWNYPKFKG--GRQAGQLSVELDLGKEENVYLAGHTIDGRV 904
            ..|.:||||.||.:.||:.|||::.|...|::.  .:.:|:....::|..:...:|:||.|||::
  Fly   840 ERIQFPVSRTTPSVSSLIRWDHSEDWFVTKYENMKTKSSGERVFSVNLASDNEEFLSGHIIDGKI 904

  Fly   905 LFPATGYMTLAWMSLA-QQQGLDYLRTPVLFEDVVFHRATILSVGTVVKLTLNFFPGSSSFEICE 968
            |.|||.|:...|.:.: ...|..|:..||.|||:.|.|||.:.|...|.||:....|:..|||.|
  Fly   905 LVPATCYLQYVWETFSLMYHGPSYMDVPVEFEDIRFIRATSMPVDGKVDLTVMIHYGTGHFEITE 969

  Fly   969 GTSLVTSGKIRLVSNVQQEQL----QLSSLPGIAGSNKLSTKDIYKELRLRGYDYTGVFQGILES 1029
            ..|||.:|.||...|....::    ..|..|.||      .||.||||:||||.|.|.||.:..:
  Fly   970 MGSLVVTGIIRETENPSIPEVYNFQSKSKFPMIA------KKDFYKELKLRGYHYNGAFQAVNLA 1028

  Fly  1030 DISAVTGQLQWADNWISFMDTMLQFRILSNDIRELYVPTGIERALIDPLKHLELAKKHQQKLTVN 1094
            ....:.|::||..||::|||.|||.:||..|.|.|.:||.|.:..|:.:.|.:|..|...:    
  Fly  1029 RSDGLFGRVQWNYNWVTFMDAMLQIQILGTDSRNLLLPTKIRKLKINGVHHFDLMTKMDPE---- 1089

  Fly  1095 WHRNISV--------VKCGGVEIHKMKTAQTQRRSGGQSP--PSLERYRFWP--HSQHLGQREEQ 1147
             :|...|        :..||:||..:..:..|||   :.|  |.||.|.|.|  .|..|      
  Fly  1090 -NRVFDVYVDPMYDRIIAGGIEIFGLHASLVQRR---RPPGIPVLEEYVFLPFFSSSIL------ 1144

  Fly  1148 EKSRSTALAVAIQLIIENSGGAVKLKGVELA--GSRSTLDALSAVQLLELIEREPILVGDMAVVT 1210
              |...|..|.:|:.|||: ..:|||.||:.  |....|     .:.:|.|:..|::.||..::|
  Fly  1145 --SLKNAARVCVQIAIENN-PTLKLKLVEVGADGKNHML-----TEFIEAIQDLPVITGDYILLT 1201

  Fly  1211 SSSNESELGEQLKEHGIRVIVKDIKAGAVEQQCHFVYSVNMLAQNSVKDLQHCLDSLKSDSGFLL 1275
            |.:.|...|..::...:          :.:..||.:. :....::.|.:......::..|:|:::
  Fly  1202 SQNLEDLPGVHIENGSL----------STQTNCHIII-IGGYEEDEVHEKITSAYNVLVDNGYIV 1255

  Fly  1276 LEE---------AASRYNIIGKEKLNKLKLVSVLEQFFGTDRVLVLVRKLSKVQSSQALTLHLT- 1330
            ..:         .|.::..|.|..:|            .|:..|||::|:||..:...:.:.:: 
  Fly  1256 FRQKCAKNVSCKIAEKFRTISKIPIN------------NTEENLVLLQKISKKLTVPPVLVKVSQ 1308

  Fly  1331 -NKQFKWVNELKNS-IAKAQAEEKNLYLVAQGEPNSGALGLMNCLKREAGGHFLRLYLILDEGVP 1393
             :|.|:|:.||::: |.||.     :.:.:..|..:|.:||:|||::|..|:.:|.:.|.|:..|
  Fly  1309 HDKTFEWILELQSAIITKAP-----VVVYSFNEKLNGQIGLVNCLRKEPDGNLIRCFFIDDDSAP 1368

  Fly  1394 QFSLDDPFYAAQLAKDLVVNVYRNGSWGSYRHLK-MESRPPMLPVEQAYVNTLVKGDLSSLRWIE 1457
            .|.|..|||:.|.:..|..|:||||||||||||: :::..|...::..|.|.:.:||||||:|::
  Fly  1369 DFDLSHPFYSTQYSLGLAFNIYRNGSWGSYRHLQLLKNDQPSKRLDHIYGNVIQRGDLSSLQWLK 1433

  Fly  1458 SPRSSPIQSQLEPC--TVYYAPLNFRDVMLASGKLGVDALPGDLAYQDCVLGLEFAGRDS-CGRR 1519
            .|.:|      :.|  .:.::.|||||||||:|:|.|:........|:||||.|::|.:. .|||
  Fly  1434 GPFNS------QNCHIKIAFSSLNFRDVMLATGRLAVELYGSSRIDQNCVLGFEYSGINMLTGRR 1492

  Fly  1520 VMAMVTAKSLATNCLANRNLLWEVPSKWTMEQASTVPCVYATVYYALVVRGQMKEGERILIHAGS 1584
            :|:||....:|:.......|:|::|..|::|:|:|||.||.|||||..:...:::|:.||||||:
  Fly  1493 IMSMVVKGGVASYVEKPSKLIWDIPDDWSLEEAATVPVVYITVYYAFFMATDIRKGKSILIHAGT 1557

  Fly  1585 GGVGQAAISVALAHGLTVFTTVGSKEKREFLLKRFPKLKAKNIGNSRDTSFEQLIMSETHGNGVE 1649
            ||:|.|||.||||:.|.||||..:..|:|||||.|||||..:|||||:||||.::..||:|.||:
  Fly  1558 GGIGLAAIRVALAYNLEVFTTCSTANKKEFLLKTFPKLKESHIGNSRNTSFELMVHRETNGKGVD 1622

  Fly  1650 LVLNSLSEEKLQASIRCLALNGRFLEIGKFDLSNNTPLGMSVFLKNTSFHGILLDSVMEGEEEMQ 1714
            .||||||||||.||:|||..:|.||||||:|::|:..:|:..|||..:||.:|.||::...:|..
  Fly  1623 FVLNSLSEEKLLASLRCLGKSGHFLEIGKYDMANDNKIGLGCFLKEITFHAVLADSLLVAPDEDI 1687

  Fly  1715 LMVAKLVAEGIKSGAVQPLPTTVFAEQEIEKAFRFMASGKHIGKVVIKVRLEEEQQAALPRLRQI 1779
            ..:..|:...|.:|.:||||..||...|||:|||.:..|||||||||:||.:....:.||    :
  Fly  1688 WHLKSLIDMDISNGIIQPLPVKVFLAHEIEQAFRHLIGGKHIGKVVIQVREQPHDPSTLP----V 1748

  Fly  1780 QAIPRSYMHPEKSYILVGGLGGFGLELANWLVSRGARFLVLSSRSGVKSGYQALMIRRWHDRGVQ 1844
            :.:.:.|.....:|::.|||||||:|||:|:..||||.|:|||..|:...||...|..|...|.:
  Fly  1749 RVLNQVYFKHNHTYVIPGGLGGFGMELADWMAIRGARKLLLSSSRGITKDYQLYRIALWKTYGCE 1813

  Fly  1845 VQIDTNDVTTAVGCQRLLEVSNKLALVGGIFNLAAVLRDGLIEDQSPKNFEKVSAPKLLATIHLD 1909
            |.|.|.|:|:..||.:||..:|.:..||||||||.||:|.:..:|:...|.:..|||.:||.:||
  Fly  1814 VAISTADITSKKGCAQLLSEANGMGPVGGIFNLAVVLKDCIFSNQNVNQFLECFAPKAIATTYLD 1878

  Fly  1910 KISREICPALEYFVCFSSLSCGRGNMGQTNYGLANSTMERICEQRQEYGYPGTAIQWGAIGDTGL 1974
            .:||..||.||:||.|||:||||||.||:|||:|||.||||.|.|...|:||.||||||||:.||
  Fly  1879 DLSRIYCPELEHFVVFSSVSCGRGNAGQSNYGMANSVMERIIEHRNREGFPGKAIQWGAIGEVGL 1943

  Fly  1975 IIEHMGNN-ETVVGGTLPQRMISCLETLDLFLQQPHPVMASMVVAEKRKTEQANRLSLIATIANI 2038
            :.:...:. :..:||||.||:.||::.||..|.....:::|||||||| |.::.:.::|..:.||
  Fly  1944 VADMAEDKIDMEIGGTLQQRISSCIQELDHLLCADASIVSSMVVAEKR-TMRSGQGNVIDAVMNI 2007

  Fly  2039 MGLRDVKSVSDKTTLFDLGMDSLMSTEIKQTLERHFDLVLSAQEIRQLTFSALRQ-IDAQEPPSA 2102
            ||:||:||||..|||.::||||||:.||||||||.|:|:|:.|::|.|||..|:: |||:|    
  Fly  2008 MGIRDLKSVSLSTTLSEMGMDSLMAVEIKQTLERDFELILTPQDLRHLTFQKLQEFIDAKE---- 2068

  Fly  2103 SVSSPSASSTLSRIKEEACVEVQPQSDETRKVFAKE--VLPQEVMVR--------------LRSK 2151
                          ||        .:|..:.:||.:  :|..|:::|              |::.
  Fly  2069 --------------KE--------NTDGIQIIFASDNKLLGMELLIRNLGDEANCDQIIIPLQTS 2111

  Fly  2152 APVASEDPAVFFLAP-IEGFT-IAVEALAASLTCPAYGLQCTEQVPLDSIEACAAYYLRQIQK-L 2213
            |..:.::.....:.| :||.. .|...|.:.|..||..||..:...|::::..|.....||:. |
  Fly  2112 AAPSKQNLQPNIIIPGLEGTAGRAWYQLGSKLQSPAIVLQLHQFAHLENLKDVAQQSFDQIKLIL 2176

  Fly  2214 QPLGPYHIVGYSYGCLLAHAIAVALEQRRFGVKVIMLDGAPTMASGYVQEAKKQTDDLNRQQSMT 2278
            :...|::|:.||||..:|..:|..||...|...:::|||||..              |.|   :|
  Fly  2177 KQTEPFYIIAYSYGTFVALLLAEMLENSGFRGHLMLLDGAPHF--------------LKR---LT 2224

  Fly  2279 LAYFGALLADVDYNQVLLQLL----------DGVQTWPSKLDKLADTLA---GYTQQTREVIKK- 2329
            ..:.|...:|.|...:|...:          :.:.|...::|.|:|.::   .|.::.....|| 
  Fly  2225 NLHLGEQFSDNDLYDLLFSSIVNHIFPEASKESMSTVFHQVDCLSDKMSLFMNYVEKQNMYSKKY 2289

  Fly  2330 ----AACMFKQ-KLLLSESYKGAKQLHSDVVLIKSAEHN-AIMAQDYGLKEICSAQIDMHVVEGT 2388
                ...||.: |:..|....|..::.|.:.|::.||.: ..:.:||.:..:.|..:.:.|:||.
  Fly  2290 SSTMVKAMFNRVKMAASFDLDGIIKIKSPITLVRPAEASLQDIDEDYCISLLTSGVVTLKVIEGN 2354

  Fly  2389 HRTFLKEPHTLQIIE 2403
            |.|.|..|...|||:
  Fly  2355 HTTMLDNPSLSQIID 2369

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FASN2NP_001259986.1 PksD 15..1043 CDD:225858 449/1040 (43%)
PKS 18..423 CDD:238429 199/404 (49%)
KAsynt_C_assoc 381..498 CDD:292814 42/119 (35%)
Acyl_transf_1 518..835 CDD:298668 142/316 (45%)
hot_dog 875..1072 CDD:294345 78/201 (39%)
NADB_Rossmann 1263..>1429 CDD:304358 54/178 (30%)
PKS_ER 1471..1761 CDD:214840 146/292 (50%)
enoyl_red 1473..1761 CDD:176179 145/288 (50%)
KR_1_FAS_SDR_x <1780..2018 CDD:187657 115/238 (48%)
PKS_PP 2031..>2083 CDD:214834 32/51 (63%)
Abhydrolase 2159..2408 CDD:304388 67/268 (25%)
FASN3NP_001015405.3 PKS 19..421 CDD:238429 199/405 (49%)
PKS_KS 21..421 CDD:214836 198/403 (49%)
KAsynt_C_assoc 383..492 CDD:292814 42/112 (38%)
Acyl_transf_1 517..831 CDD:298668 141/314 (45%)
hot_dog 877..1076 CDD:294345 79/204 (39%)
NADB_Rossmann <1301..>1411 CDD:304358 42/114 (37%)
enoyl_red 1443..1734 CDD:176179 145/290 (50%)
PKS_ER 1443..1734 CDD:214840 145/290 (50%)
KR_1_FAS_SDR_x <1761..1988 CDD:187657 114/226 (50%)
PKS_PP 2000..2067 CDD:214834 39/66 (59%)
Abhydrolase 2120..2375 CDD:304388 67/267 (25%)
MhpC 2120..2371 CDD:223669 67/267 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 47 1.000 Domainoid score I4520
eggNOG 1 0.900 - - E1_COG3321
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S4124
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1091at50557
OrthoFinder 1 1.000 - - FOG0001625
OrthoInspector 1 1.000 - - otm24450
orthoMCL 1 0.900 - - OOG6_100178
Panther 1 1.100 - - P PTHR43775
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
98.770

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