DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FASN2 and SPAPB24D3.08c

DIOPT Version :9

Sequence 1:	NP_001259986.1	Gene:	FASN2 / 117361	FlyBaseID:	FBgn0042627	Length:	2410	Species:	Drosophila melanogaster
Sequence 2:	NP_593994.1	Gene:	SPAPB24D3.08c / 2543522	PomBaseID:	SPAPB24D3.08c	Length:	349	Species:	Schizosaccharomyces pombe

Alignment Length:	422	Identity:	96/422 - (22%)
Similarity:	162/422 - (38%)	Gaps:	124/422 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1382 LRLYLILDEGVP-----------QFSLDDPFYAAQLAKD---LVVNVYRNGSWGSYRHLKMESRP 1432
            ::.||....|.|           :|.|::    ||:.::   |:.|:|.  |...|..::|:|
pombe     9 IKKYLDSTAGYPVIGEHLAFEKREFDLEN----AQVDEETPVLLKNIYT--SVDPYLRMRMQS-- 65

  Fly  1433 PMLPVEQAYVNTLVKGDLSSLRWIESPRSSPIQSQLEPCTVYYAPLNFRDVMLASGKLGVDALPG 1497
               |...:|:..|..|.    .:..|..:..::|.|:    .|.|  ..||:..||
pombe    66 ---PKHASYIPPLELGK----PFYNSTVAKVVKSTLD----QYKP--GMDVVFVSG--------- 108

  Fly  1498 DLAYQDCVLGLEFAGRDSCGRRVMAMVTAKSLATNCLANRNLLWEVPSKWTMEQASTVPCVYATV 1562
               :::    ..|..:.:.|               .|...|..:::|   .::...::.....|.
pombe   109 ---WEE----YTFVSKQALG---------------FLQPINNPYKLP---LIDFVGSLGMPSQTA 148

  Fly  1563 YYALVVRGQMKEGERILIHAGSGGVGQAAISVALAHGLTVFTTVGSKE----------------K 1611
            |..|...|:.|.||.|.|.|.||.|||.|..:|.|.||.|..:|||.|                |
pombe   149 YCGLKHIGKPKAGETIYISAASGAVGQMAGQLAKAMGLHVVGSVGSDEKFKICLDSGYDSVFNYK 213

  Fly  1612 REFLLKRFPKLKAKNIGNSRDTSFEQLIMSETHGNGVELVLNSLSEEKLQASIRCLALNGRFLEI 1676
            :|...|..|:|..|                     |:::...::..|.:.|.:..:.|.||.:..
pombe   214 KESPFKALPRLCPK---------------------GIDIYFENVGGETMDAVLENMNLQGRIIFC 257

  Fly  1677 GKFDLSNN-TP-----LGMSVFLKNTSFHGILLDSVM-EGEEEMQLMVAKLVAEG---IKSGAVQ 1731
            |.....|| .|     ||| |.:|:.:..|.::.::: :.:|:....:.||:|||   .|.....
pombe   258 GAISQYNNPNPYRVKNLGM-VLVKSLTIQGFIVANILPQYQEQYFEEMPKLIAEGKIKYKCDVYD 321

  Fly  1732 PLPTTVFAEQEIEKAFRFMASGKHIGKVVIKV 1763
            .|       :...:||..|..||:.||.::|:
pombe   322 GL-------ESAPEAFIGMLQGKNSGKTIVKI 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FASN2	NP_001259986.1	PksD	15..1043	CDD:225858
		PKS	18..423	CDD:238429
		KAsynt_C_assoc	381..498	CDD:292814
		Acyl_transf_1	518..835	CDD:298668
		hot_dog	875..1072	CDD:294345
		NADB_Rossmann	1263..>1429	CDD:304358	13/60 (22%)
		PKS_ER	1471..1761	CDD:214840	73/315 (23%)
		enoyl_red	1473..1761	CDD:176179	73/313 (23%)
		KR_1_FAS_SDR_x	<1780..2018	CDD:187657
		PKS_PP	2031..>2083	CDD:214834
		Abhydrolase	2159..2408	CDD:304388
SPAPB24D3.08c	NP_593994.1	CurA	1..348	CDD:225041	96/422 (23%)
SPAPB24D3.08c	NP_593994.1	PGDH	3..344	CDD:176190	95/418 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1925
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030