DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FASN2 and SPBC1773.06c

DIOPT Version :9

Sequence 1:	NP_001259986.1	Gene:	FASN2 / 117361	FlyBaseID:	FBgn0042627	Length:	2410	Species:	Drosophila melanogaster
Sequence 2:	NP_595121.1	Gene:	SPBC1773.06c / 2540139	PomBaseID:	SPBC1773.06c	Length:	346	Species:	Schizosaccharomyces pombe

Alignment Length:	363	Identity:	92/363 - (25%)
Similarity:	144/363 - (39%)	Gaps:	94/363 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1459 PRSSPIQSQLEPCTVYY----APLNFRDVMLASG---------------------KLG------- 1491
            |....:..:|.|..|..    |.||:||:::..|                     |:|
pombe    19 PEEYEVPQKLNPGEVLVKLKAASLNYRDLIITKGLYPLPLQLPVVPGSDGAGIIEKVGEDVEGFE 83

  Fly  1492 -------------VDALPGDLAYQDCVLGLEFAGRDSCGRRVMAMVTAKSLATNCLANRNLLWEV 1543
                         :|..|.|.|....:.|.    ||.|.:: .|::.|.:|.           ..
pombe    84 KGDSVVCNFFTNYLDGTPTDFATHSALGGT----RDGCFQK-YAVLPAHALV-----------HA 132

  Fly  1544 PSKWTMEQASTVPCVYATVYYALV--VRGQMKEGERILIHAGSGGVGQAAISVALAHGLTVFTTV 1606
            |...:.|:.:|:||...|.:..|.  ...|:|.|..:|: .|:|||...|:..|||.|..|..|.
pombe   133 PKNLSFEEIATLPCAAVTAWNGLFGSKEHQVKPGNNVLV-LGTGGVSTFALQFALAAGANVTVTS 196

  Fly  1607 GSKEKREFLLKRFPKLKAKNIGNSRDTSFEQL------IMSETHGNGVELVLNSLSEEKLQASIR 1665
            .|.||.||         ||.:|.:...::::.      .:..|:|.|...|:....|:.|..||.
pombe   197 SSDEKLEF---------AKKLGATHTINYKKTPQWASPALKMTNGVGYHHVIEVGGEKTLPQSIA 252

  Fly  1666 CLALNGRFLEIGKFDLSNNTP-----LGMSVFLKNTSFHGILLDSVMEGEEEMQLMVAKLVAEGI 1725
            |||.:|....||.......||     :| .:..:|.:..||.:.||....:    |||.:.|:.|
pombe   253 CLAKDGMISMIGFVASEGTTPNLTSIIG-QILNRNANIRGIFVGSVSMFRD----MVACIEAKDI 312

  Fly  1726 KSGAVQPLPTTVFAEQEIEKAFRFMASGKHIGKVVIKV 1763
                 .|:...||...::::|:.:..|..||||||:|:
pombe   313 -----HPVVDKVFPFDQLKEAYEYQWSQAHIGKVVLKI 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FASN2	NP_001259986.1	PksD	15..1043	CDD:225858
		PKS	18..423	CDD:238429
		KAsynt_C_assoc	381..498	CDD:292814
		Acyl_transf_1	518..835	CDD:298668
		hot_dog	875..1072	CDD:294345
		NADB_Rossmann	1263..>1429	CDD:304358
		PKS_ER	1471..1761	CDD:214840	87/347 (25%)
		enoyl_red	1473..1761	CDD:176179	87/345 (25%)
		KR_1_FAS_SDR_x	<1780..2018	CDD:187657
		PKS_PP	2031..>2083	CDD:214834
		Abhydrolase	2159..2408	CDD:304388
SPBC1773.06c	NP_595121.1	Qor	4..345	CDD:223677	91/361 (25%)
SPBC1773.06c	NP_595121.1	MDR7	12..345	CDD:176237	91/361 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	44	1.000	Domainoid score	I3590
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9266
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910