DRSC/TRiP Functional Genomics Resources

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Protein Alignment FASN2 and PTGR1

DIOPT Version :9

Sequence 1:NP_001259986.1 Gene:FASN2 / 117361 FlyBaseID:FBgn0042627 Length:2410 Species:Drosophila melanogaster
Sequence 2:NP_001139580.1 Gene:PTGR1 / 22949 HGNCID:18429 Length:329 Species:Homo sapiens


Alignment Length:349 Identity:78/349 - (22%)
Similarity:123/349 - (35%) Gaps:86/349 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  1463 PIQSQLEPCTVYYAPLNFRDVMLASGKLGVDALPGDLAYQDCVLGLEFAGRDSCGRRVMAMVTAK 1527
            |..|..|..|....||...:|:|.:..|.||      .|..........|....|::|..:|.:|
Human    17 PTNSDFELKTAELPPLKNGEVLLEALFLTVD------PYMRVAAKRLKEGDTMMGQQVAKVVESK 75

  Fly  1528 SLA----TNCLANRNLLWEVPS--------KWTMEQASTVPCVYA---------TVYYALVVRGQ 1571
            ::|    |..||:..  |...|        |...|...|:|...|         |.|:.|:....
Human    76 NVALPKGTIVLASPG--WTTHSISDGKDLEKLLTEWPDTIPLSLALGTVGMPGLTAYFGLLEICG 138

  Fly  1572 MKEGERILIHAGSGGVGQAAISVALAHGLTVFTTVGSKEKREFLLKRFPKLKAKNIGNSRDTSFE 1636
            :|.||.::::|.:|.||.....:|...|..|...|||.||..:|    .||....:.|.:.....
Human   139 VKGGETVMVNAAAGAVGSVVGQIAKLKGCKVVGAVGSDEKVAYL----QKLGFDVVFNYKTVESL 199

  Fly  1637 QLIMSETHGNGVELVLNSLSEEKLQASIRCLALNGRFLEIGKFDLSNNT---------------P 1686
            :..:.:...:|.:...:::..|.....|..:...||....|.....|.|               .
Human   200 EETLKKASPDGYDCYFDNVGGEFSNTVIGQMKKFGRIAICGAISTYNRTGPLPPGPPPEIVIYQE 264

  Fly  1687 LGMSVF-------------LKNTSFHGILLDSVMEGEEEMQLMVAKLVAEGIKSGAVQPLPTTVF 1738
            |.|..|             ||:      ||..|:||    ::...:.:.||.::     :|.   
Human   265 LRMEAFVVYRWQGDARQKALKD------LLKWVLEG----KIQYKEYIIEGFEN-----MPA--- 311

  Fly  1739 AEQEIEKAFRFMASGKHIGKVVIK 1762
                   ||..|..|.::||.::|
Human   312 -------AFMGMLKGDNLGKTIVK 328

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FASN2NP_001259986.1 PksD 15..1043 CDD:225858
PKS 18..423 CDD:238429
KAsynt_C_assoc 381..498 CDD:292814
Acyl_transf_1 518..835 CDD:298668
hot_dog 875..1072 CDD:294345
NADB_Rossmann 1263..>1429 CDD:304358
PKS_ER 1471..1761 CDD:214840 74/338 (22%)
enoyl_red 1473..1761 CDD:176179 73/336 (22%)
KR_1_FAS_SDR_x <1780..2018 CDD:187657
PKS_PP 2031..>2083 CDD:214834
Abhydrolase 2159..2408 CDD:304388
PTGR1NP_001139580.1 leukotriene_B4_DH_like 2..329 CDD:176254 78/349 (22%)
B4_12hDH 4..328 CDD:131872 77/347 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1925
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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