back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FASN2 and FASN

DIOPT Version :9

Sequence 1:	NP_001259986.1	Gene:	FASN2 / 117361	FlyBaseID:	FBgn0042627	Length:	2410	Species:	Drosophila melanogaster
Sequence 2:	NP_004095.4	Gene:	FASN / 2194	HGNCID:	3594	Length:	2511	Species:	Homo sapiens

Alignment Length:	2553	Identity:	1098/2553 - (43%)
Similarity:	1564/2553 - (61%)	Gaps:	245/2553 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DIVISGLSGKLPESSNIEEFKYNLLNGIDMVTDEPRRWEAGIYGLPERMAKMKDSDLEKFDDKFF 82
            ::||:|:|||||||.|::||..||:.|:|||||:.|||:||:||||.|..|:|  ||.:||..||
Human     3 EVVIAGMSGKLPESENLQEFWDNLIGGVDMVTDDDRRWKAGLYGLPRRSGKLK--DLSRFDASFF 65

  Fly    83 SVHQKQAELMDPCMRMLLELTHEAIIDAGINPVQLRGSRTGVYIGLSFVETEHEIPNMEPSSING 147
            .||.|||..|||.:|:|||:|:|||:|.||||..|||:.|||::|:|..||. |..:.:|.::.|
Human    66 GVHPKQAHTMDPQLRLLLEVTYEAIVDGGINPDSLRGTHTGVWVGVSGSETS-EALSRDPETLVG 129

  Fly   148 YCLTGCARAMFANRISYTFDFKGPSFIVDTACSSSLVALNHAFADMRAGRCDYALVAGVNLILKP 212
            |.:.||.|||.|||:|:.|||:|||..:||||||||:||.:|:..:.:|:|..|:|.|:|::|||
Human   130 YSMVGCQRAMMANRLSFFFDFRGPSIALDTACSSSLMALQNAYQAIHSGQCPAAIVGGINVLLKP 194

  Fly   213 IFALQFLRLGIVSHDGSCKTFDAAANGYARADTCAVVLLQRRKEAKRVYASILNVRTNTDGFKEQ 277
            ..::||||||::|.:|:||.||.|.|||.|::....|||.::..|:||||:|||..|||||||||
Human   195 NTSVQFLRLGMLSPEGTCKAFDTAGNGYCRSEGVVAVLLTKKSLARRVYATILNAGTNTDGFKEQ 259

  Fly   278 GVTFPDGRMQQALLEETYSEIGLNPDEVVYVEAHGSGTPVGDDQEANMLSNFFCRPSRSTPLLIG 342
            |||||.|.:|:.|:...|...|:.|:...|:||||:||.|||.||.|.::...| .:|..|||||
Human   260 GVTFPSGDIQEQLIRSLYQSAGVAPESFEYIEAHGTGTKVGDPQELNGITRALC-ATRQEPLLIG 323

  Fly   343 SVKSNMGHAEPASGVSALAKMIIAMEEGIIPKNLHYRTPNPSVPALVEGKLKVVDRNLPWQGGIV 407
            |.||||||.|||||::||||:::::|.|:...|||:.:|||.:|||::|:|:|||:.||.:||.|
Human   324 STKSNMGHPEPASGLAALAKVLLSLEHGLWAPNLHFHSPNPEIPALLDGRLQVVDQPLPVRGGNV 388

  Fly   408 GLNSFGFGGANAHVVLKSHTKAKEPKACPKAGEAEQSL-SLVTCSGRTEDAVNQLLKVATEQ--R 469
            |:|||||||:|.|::|:.:|:.      |.|.....:| .|:..||||.:||.:||    ||  |
Human   389 GINSFGFGGSNVHIILRPNTQP------PPAPAPHATLPRLLRASGRTPEAVQKLL----EQGLR 443

  Fly   470 HDQEL--LTLINDIHSHPIPLHPFRGYAVLG--TSGCVKEEVLPYEEEERPIWFVYAGMGSQWAR 530
            |.|:|  |:::|||.:.|....|||||||||  ..|   .||......|||:||:.:|||:||..
Human   444 HSQDLAFLSMLNDIAAVPATAMPFRGYAVLGGERGG---PEVQQVPAGERPLWFICSGMGTQWRG 505

  Fly   531 MAKDLMQLEVFRNSIQHCAEVLAQVDFDLIDVLTRSTERTFDNMLYSFVSVSAVQVALTDLLRVL 595
            |...||:|:.||:||....|.:......:..:|..:.|.|||::::||||::|:|:.|.|||..:
Human   506 MGLSLMRLDRFRDSILRSDEAVKPFGLKVSQLLLSTDESTFDDIVHSFVSLTAIQIGLIDLLSCM 570

  Fly   596 DIRPDGIIGHSAGELGAAYMDGCLTAEQTVLAAYWRGRSVLDTPDLPRGKMAAVGLSWEQIGSQI 660
            .:|||||:|||.||:...|.||||:.|:.||||||||:.:.:. .||.|.|||||||||:...:.
Human   571 GLRPDGIVGHSLGEVACGYADGCLSQEEAVLAAYWRGQCIKEA-HLPPGAMAAVGLSWEECKQRC 634

  Fly   661 PKDCYPVCHNSDDNCTVSGPPSSMDAMIEDLTAKGIFVREVGSGGYAFHSPYIEGAAPMLRRSLE 725
            |....|.||||.|..|:|||.:.:...:|.|..:|:|.:||.:||.||||.::|..||.|.:.|:
Human   635 PPGVVPACHNSKDTVTISGPQAPVFEFVEQLRKEGVFAKEVRTGGMAFHSYFMEAIAPPLLQELK 699

  Fly   726 RLITEPKKKSIRWLSTSVKEAEWDSEKNHLASAGYFINNLISPVLFHQAVKRIPQNALIVEIAPH 790
            ::|.|||.:|.||||||:.||:|.|.....:||.|.:|||:|||||.:|:..:|::|:::|||||
Human   700 KVIREPKPRSARWLSTSIPEAQWHSSLARTSSAEYNVNNLVSPVLFQEALWHVPEHAVVLEIAPH 764

  Fly   791 GLFRAIL-RSLSPQISYVSLMQRGHANNFEFLLSQLGRLYAAGGQPQILKISPSIPYPVSRGTPM 854
            .|.:|:| |.|.|..:.:.||::.|.:|.||.|:.:|||:.:|.......:.|.:.:|..||||:
Human   765 ALLQAVLKRGLKPSCTIIPLMKKDHRDNLEFFLAGIGRLHLSGIDANPNALFPPVEFPAPRGTPL 829

  Fly   855 LGSLVGWDHTQKWNYP---KFKGGRQAGQLSV-ELDLGKEE-NVYLAGHTIDGRVLFPATGYMTL 914
            :..|:.|||:..|:.|   .|..|..:...:: .:|...|. :.||..||:|||||||||||:::
Human   830 ISPLIKWDHSLAWDVPAAEDFPNGSGSPSAAIYNIDTSSESPDHYLVDHTLDGRVLFPATGYLSI 894

  Fly   915 AWMSLAQQQGLDYLRTPVLFEDVVFHRATILSVGTVVKLTLNFFPGSSSFEICEGTSLVTSGKI- 978
            .|.:||:..||...:.||:|||||.|:||||.....|.|.:.....|.:||:.|..:||.|||:
Human   895 VWKTLARALGLGVEQLPVVFEDVVLHQATILPKTGTVSLEVRLLEASRAFEVSENGNLVVSGKVY 959

  Fly   979 -------RLVSNVQQEQLQLSSLPGIAGSNKLSTKDIYKELRLRGYDYTGVFQGILESDISAVTG 1036
                   ||..:.:      |..|.......|:..::|||||||||||...||||||:.:...:|
Human   960 QWDDPDPRLFDHPE------SPTPNPTEPLFLAQAEVYKELRLRGYDYGPHFQGILEASLEGDSG 1018

  Fly  1037 QLQWADNWISFMDTMLQFRILSNDIRELYVPTGIERALIDPLKHLELAKKHQQKLTV------NW 1095
            :|.|.|||:||||||||..||.:....||:||.:....|||..|.:.....|.|..|      .|
Human  1019 RLLWKDNWVSFMDTMLQMSILGSAKHGLYLPTRVTAIHIDPATHRQKLYTLQDKAQVADVVVSRW 1083

  Fly  1096 HRNISVVKCGGVEIHKMKTAQTQRRSGGQSPPSLERYRFWPHSQH--LGQRE--EQEKSRSTALA 1156
            .|   |...|||.|..:.|....||...|..|.||::.|.||::.  |.:|.  ::|......|.
Human  1084 LR---VTVAGGVHISGLHTESAPRRQQEQQVPILEKFCFTPHTEEGCLSERAALQEELQLCKGLV 1145

  Fly  1157 VAIQLIIENSGGAVKLKGVE-----------------LAGSRSTLDALSAVQLLELIERE----- 1199
            .|:|..:...|..:.:.|::                 .|..|..|:....::|.:::.:|
Human  1146 QALQTKVTQQGLKMVVPGLDGAQIPRDPSQQELPRLLSAACRLQLNGNLQLELAQVLAQERPKLP 1210

  Fly  1200 --PILVG-----------DMAVVTSSSNESELGEQLKEHG-----------------IRVIVKD- 1233
              |:|.|           |.||....|.:.::.|.|..||                 :.....|
Human  1211 EDPLLSGLLDSPALKACLDTAVENMPSLKMKVVEVLAGHGHLYSRIPGLLSPHPLLQLSYTATDR 1275

  Fly  1234 ----IKAGAVEQQCHFVY---------------SVNMLAQN----SVKDLQHCLDSLKS---DSG 1272
                ::|...|.|.|.|.               |.::|..|    ::.|....|.::.:   :.|
Human  1276 HPQALEAAQAELQQHDVAQGQWDPADPAPSALGSADLLVCNCAVAALGDPASALSNMVAALREGG 1340

  Fly  1273 FLLLE------------------EAASRYNIIGKEKLN------KLKLVSVLEQFFGTDRVLVLV 1313
            ||||.                  |......|:.::...      .|:||.:.:.|:|:  .|.|.
Human  1341 FLLLHTLLRGHPLGDIVAFLTSTEPQYGQGILSQDAWESLFSRVSLRLVGLKKSFYGS--TLFLC 1403

  Fly  1314 RKLSKVQSSQALTLHLTNKQFKWVNELKNSIAKAQAEEKNLYLVAQGEPNSGALGLMNCLKREAG 1378
            |:.:...|  .:.|.:.:..|:||..||..:|. :...:.::|.|.....||.:||:|||:||.|
Human  1404 RRPTPQDS--PIFLPVDDTSFRWVESLKGILAD-EDSSRPVWLKAINCATSGVVGLVNCLRREPG 1465

  Fly  1379 GHFLRLYLILD----EGVPQFSLDDPFYAAQLAK----DLVVNVYRNGSWGSYRHLKMESRPPML 1435
            |:.||..|:.:    ..||:.   || .:|:|.|    |||:||||:|:||::||..:|...|..
Human  1466 GNRLRCVLLSNLSSTSHVPEV---DP-GSAELQKVLQGDLVMNVYRDGAWGAFRHFLLEEDKPEE 1526

  Fly  1436 PVEQAYVNTLVKGDLSSLRWIESP--RSSPIQSQLEPCTVYYAPLNFRDVMLASGKLGVDALPGD 1498
            |...|:|:||.:|||||:||:.|.  .:.|.....:.||||||.|||||:|||:|||..||:||.
Human  1527 PTAHAFVSTLTRGDLSSIRWVCSSLRHAQPTCPGAQLCTVYYASLNFRDIMLATGKLSPDAIPGK 1591

  Fly  1499 LAYQDCVLGLEFAGRDSCGRRVMAMVTAKSLATNCLANRNLLWEVPSKWTMEQASTVPCVYATVY 1563
            ...||.:||:||:|||:.|:|||.:|.||.|||:.|.:.:.||:|||.||:|:|::||.||:|.|
Human  1592 WTSQDSLLGMEFSGRDASGKRVMGLVPAKGLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAY 1656

  Fly  1564 YALVVRGQMKEGERILIHAGSGGVGQAAISVALAHGLTVFTTVGSKEKREFLLKRFPKLKAKNIG 1628
            |||||||:::.||.:|||:||||||||||::||:.|..|||||||.|||.:|..|||:|.:.:..
Human  1657 YALVVRGRVRPGETLLIHSGSGGVGQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLDSTSFA 1721

  Fly  1629 NSRDTSFEQLIMSETHGNGVELVLNSLSEEKLQASIRCLALNGRFLEIGKFDLSNNTPLGMSVFL 1693
            |||||||||.::..|.|.||:||||||:|||||||:||||.:||||||||||||.|.||||::||
Human  1722 NSRDTSFEQHVLWHTGGKGVDLVLNSLAEEKLQASVRCLATHGRFLEIGKFDLSQNHPLGMAIFL 1786

  Fly  1694 KNTSFHGILLDSVMEGEEEMQLMVAKLVAEGIKSGAVQPLPTTVFAEQEIEKAFRFMASGKHIGK 1758
            ||.:|||:|||:...........|..||..||:.|.|:||..|||...::|.|||:||.||||||
Human  1787 KNVTFHGVLLDAFFNESSADWREVWALVQAGIRDGVVRPLKCTVFHGAQVEDAFRYMAQGKHIGK 1851

  Fly  1759 VVIKVRLEEEQQAAL----PRLRQIQAIPRSYMHPEKSYILVGGLGGFGLELANWLVSRGARFLV 1819
            ||::| |.||.:|.|    |:|  :.||.:::....||||:.|||||||||||.||:.||.:.||
Human  1852 VVVQV-LAEEPEAVLKGAKPKL--MSAISKTFCPAHKSYIIAGGLGGFGLELAQWLIQRGVQKLV 1913

  Fly  1820 LSSRSGVKSGYQALMIRRWHDRGVQVQIDTNDVTTAVGCQRLLEVSNKLALVGGIFNLAAVLRDG 1884
            |:||||:::||||..:|||..:|||||:.|:::::..|.:.|:..:.:|..|||:||||.|||||
Human  1914 LTSRSGIRTGYQAKQVRRWRRQGVQVQVSTSNISSLEGARGLIAEAAQLGPVGGVFNLAVVLRDG 1978

  Fly  1885 LIEDQSPKNFEKVSAPKLLATIHLDKISREICPALEYFVCFSSLSCGRGNMGQTNYGLANSTMER 1949
            |:|:|:|:.|:.|..||...|::||:::||.||.|:|||.|||:||||||.||:|||.|||.|||
Human  1979 LLENQTPEFFQDVCKPKYSGTLNLDRVTREACPELDYFVVFSSVSCGRGNAGQSNYGFANSAMER 2043

  Fly  1950 ICEQRQEYGYPGTAIQWGAIGDTGLIIEHMGNNETVVGGTLPQRMISCLETLDLFLQQPHPVMAS 2014
            |||:|:..|.||.|:|||||||.|:::|.|..|:|:|.|||||||.||||.|||||.|||.|::|
Human  2044 ICEKRRHEGLPGLAVQWGAIGDVGILVETMSTNDTIVSGTLPQRMASCLEVLDLFLNQPHMVLSS 2108

  Fly  2015 MVVAEKRKT--EQANRLSLIATIANIMGLRDVKSVSDKTTLFDLGMDSLMSTEIKQTLERHFDLV 2077
            .|:|||...  ::.::..|:..:|:|:|:||:.:|:..::|.|||:|||||.|::|||||..:||
Human  2109 FVLAEKAAAYRDRDSQRDLVEAVAHILGIRDLAAVNLDSSLADLGLDSLMSVEVRQTLERELNLV 2173

  Fly  2078 LSAQEIRQLTFSALRQIDAQEPPSASVSSPSASSTLSRIKEEACVEVQPQSDETRKVFAKEVLPQ 2142
            ||.:|:||||...|:::.::...::.::.|:.       ||:...:.|.|.: .|.:......|
Human  2174 LSVREVRQLTLRKLQELSSKADEASELACPTP-------KEDGLAQQQTQLN-LRSLLVNPEGP- 2229

  Fly  2143 EVMVRLRSKAPVASEDPAVFFLAPIEGFTIAVEALAASLTCPAYGLQCTEQVPLDSIEACAAYYL 2207
             .::||.|   |.|.:..:|.:.||||.|....:||:.|:.|.||||||...|||||.:.||||:
Human  2230 -TLMRLNS---VQSSERPLFLVHPIEGSTTVFHSLASRLSIPTYGLQCTRAAPLDSIHSLAAYYI 2290

  Fly  2208 RQIQKLQPLGPYHIVGYSYGCLLAHAIAVALEQRRFGV----KVIMLDGAPTMASGYVQ------ 2262
            ..|:::||.|||.:.|||||..:|..:...|:.::...    .:.:.||:||....|.|
Human  2291 DCIRQVQPEGPYRVAGYSYGACVAFEMCSQLQAQQSPAPTHNSLFLFDGSPTYVLAYTQSYRAKL 2355

  Fly  2263 ----EAKKQTDDLNRQQSMTLAYFGALLADVDYNQVLLQLLDGVQTWPSK---------LDKLAD 2314
                ||:.:|:        .:.:|.....|:::|:||..||      |.|         :|.:..
Human  2356 TPGCEAEAETE--------AICFFVQQFTDMEHNRVLEALL------PLKGLEERVAAAVDLIIK 2406

  Fly  2315 TLAGYTQQTREVIKKAACMFKQKLLLSESYKGAKQLHSDVVLIKSAEHNAI---MAQDYGLKEIC 2376
            :..|.   .|:.:..||..|..||..:|.|....:.|.:|:|:::....|.   :..||.|.::|
Human  2407 SHQGL---DRQELSFAARSFYYKLRAAEQYTPKAKYHGNVMLLRAKTGGAYGEDLGADYNLSQVC 2468

  Fly  2377 SAQIDMHVVEGTHRTFLK 2394
            ..::.:||:||.|||.|:
Human  2469 DGKVSVHVIEGDHRTLLE 2486

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.