DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FASN2 and F32H2.6

DIOPT Version :9

Sequence 1:	NP_001259986.1	Gene:	FASN2 / 117361	FlyBaseID:	FBgn0042627	Length:	2410	Species:	Drosophila melanogaster
Sequence 2:	NP_492421.1	Gene:	F32H2.6 / 185214	WormBaseID:	WBGene00009343	Length:	187	Species:	Caenorhabditis elegans

Alignment Length:	166	Identity:	64/166 - (38%)
Similarity:	89/166 - (53%)	Gaps:	17/166 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DIVISGLSGKLPESSN--IEEFKYNLLNGIDMVTDEPRRWEAGIYGLPERMAKMKDSDLEKFDDK 80
            |||||  ..::|...|  ::.|...||...|:||::...|..|...||::..|.|  ||.|||..
Worm    12 DIVIS--KDQIPRCDNKEVKMFGGMLLACDDVVTEDQLSWAPGFTDLPKKRGKKK--DLNKFDAG 72

  Fly    81 FFSVHQKQAELMDPCMRMLLELTHEAIIDAGINPVQLRGSRTGVY-----IGLSFVETEHEIPNM 140
            ......||...|||.:|:|||.:.||::||||||..||||:.|.:     .|.|..:.::.:..|
Worm    73 ILPGTSKQNNPMDPQVRLLLEASWEAMVDAGINPRGLRGSQIGDFDECATPGTSGTQKQNPVTEM 137

  Fly   141 EPSSINGYCLTGCARAMFANRISYTFDFKGPSFIVD 176
                  |..::....:||:||||||||.:|||...|
Worm   138 ------GCIMSDTVPSMFSNRISYTFDLQGPSHSAD 167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FASN2	NP_001259986.1	PksD	15..1043	CDD:225858	64/166 (39%)
		PKS	18..423	CDD:238429	64/166 (39%)
		KAsynt_C_assoc	381..498	CDD:292814
		Acyl_transf_1	518..835	CDD:298668
		hot_dog	875..1072	CDD:294345
		NADB_Rossmann	1263..>1429	CDD:304358
		PKS_ER	1471..1761	CDD:214840
		enoyl_red	1473..1761	CDD:176179
		KR_1_FAS_SDR_x	<1780..2018	CDD:187657
		PKS_PP	2031..>2083	CDD:214834
		Abhydrolase	2159..2408	CDD:304388
F32H2.6	NP_492421.1	ketoacyl-synt	<58..>167	CDD:365879	46/116 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3321
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4124
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D19161at2759
OrthoFinder	1	1.000	-	-		FOG0001625
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.770