DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FASN2 and M106.3

DIOPT Version :9

Sequence 1:	NP_001259986.1	Gene:	FASN2 / 117361	FlyBaseID:	FBgn0042627	Length:	2410	Species:	Drosophila melanogaster
Sequence 2:	NP_001379459.1	Gene:	M106.3 / 174671	WormBaseID:	WBGene00010911	Length:	373	Species:	Caenorhabditis elegans

Alignment Length:	364	Identity:	80/364 - (21%)
Similarity:	134/364 - (36%)	Gaps:	97/364 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1456 IESPRSSPIQSQLEPCTVYYAPLNFRDVMLA---------SGKLGVDALPGDLAYQDCVLGLEFA 1511
            |:||....|.|  :.|.|       |.:.|:         :...|||.| |.....:.|.|:|..
Worm    49 IDSPSEKDITS--DQCIV-------RTLFLSVDPAQRCRMNPSTGVDYL-GPYEIGEPVDGMEGV 103

  Fly  1512 GRDSCGRRVMAMVTAK--SLATNCLANRNLLW----------------EVPSKWTMEQASTVPCV 1558
            |   ...||.:..|.:  .|.|.|:.    ||                .:||......:..:.|.
Worm   104 G---VVERVGSACTLEVGDLVTGCIR----LWTWTKYFVCDSSDLVKVNLPSSRNFSPSVILSCA 161

  Fly  1559 YATVYYALVVRGQMKEG-------ERILIHAGSGGVGQAAISVALAHGLT-VFTTVGSKE----- 1610
            ..:...||:  |..|:.       :.|::...:|..|..|..:|...|.: |....||.:
Worm   162 GLSGITALL--GIRKKALIDRSRPQTIVVSGAAGSCGSLAGQIARIEGCSKVIGICGSDDKCTVL 224

  Fly  1611 KREFLLKRFPKLKAKNIGNSRDTSFEQLIMSETHGN----GVELVLNSLSEEKLQASIRCLALNG 1671
            ||||........|.:|:             ||..|:    |:::..:::........||.:...|
Worm   225 KREFGFNDTINYKTENV-------------SERLGHLAPEGIDIYWDNVGGVISDDVIRAMNNEG 276

  Fly  1672 RFLEIGKF-----DLSNNTPLGMSVFLKNTSFHGILLDSVMEGEEEMQLM--------VAKLVAE 1723
            |.:..|:.     ||....||.     ::|:  .|:.:..::.|..:.||        ||:| :|
Worm   277 RVVLCGQIAVYNTDLPYPPPLP-----EHTT--KIIKERNIQRERYLVLMYKDEIDEAVAQL-SE 333

  Fly  1724 GIKSGAVQPLPTTVFAEQEIEKAFRFMASGKHIGKVVIK 1762
            .::...::...|..........||..|.:||:|||::|:
Worm   334 WLQQDKIKVKETIYDGLNAAPSAFVDMMNGKNIGKMLIR 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FASN2	NP_001259986.1	PksD	15..1043	CDD:225858
		PKS	18..423	CDD:238429
		KAsynt_C_assoc	381..498	CDD:292814
		Acyl_transf_1	518..835	CDD:298668
		hot_dog	875..1072	CDD:294345
		NADB_Rossmann	1263..>1429	CDD:304358
		PKS_ER	1471..1761	CDD:214840	74/346 (21%)
		enoyl_red	1473..1761	CDD:176179	73/344 (21%)
		KR_1_FAS_SDR_x	<1780..2018	CDD:187657
		PKS_PP	2031..>2083	CDD:214834
		Abhydrolase	2159..2408	CDD:304388
M106.3	NP_001379459.1	PTGR2	22..373	CDD:176253	80/364 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1925
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940