back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FASN2 and Fasn

DIOPT Version :9

Sequence 1:	NP_001259986.1	Gene:	FASN2 / 117361	FlyBaseID:	FBgn0042627	Length:	2410	Species:	Drosophila melanogaster
Sequence 2:	NP_032014.3	Gene:	Fasn / 14104	MGIID:	95485	Length:	2504	Species:	Mus musculus

Alignment Length:	2538	Identity:	1082/2538 - (42%)
Similarity:	1563/2538 - (61%)	Gaps:	222/2538 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DIVISGLSGKLPESSNIEEFKYNLLNGIDMVTDEPRRWEAGIYGLPERMAKMKDSDLEKFDDKFF 82
            ::||:|:|||||||.|::||..||:.|:|||||:.|||:||:||||:|..|:|  ||.|||..||
Mouse     3 EVVIAGMSGKLPESENLQEFWANLIGGVDMVTDDDRRWKAGLYGLPKRSGKLK--DLSKFDASFF 65

  Fly    83 SVHQKQAELMDPCMRMLLELTHEAIIDAGINPVQLRGSRTGVYIGLSFVETEHEIPNMEPSSING 147
            .||.|||..|||.:|:|||:::|||:|.||||..|||:.|||::|:|..|.. |..:.:|.::.|
Mouse    66 GVHPKQAHTMDPQLRLLLEVSYEAIVDGGINPASLRGTNTGVWVGVSGSEAS-EALSRDPETLLG 129

  Fly   148 YCLTGCARAMFANRISYTFDFKGPSFIVDTACSSSLVALNHAFADMRAGRCDYALVAGVNLILKP 212
            |.:.||.|||.|||:|:.|||||||..:||||||||:||.:|:..:|:|.|..|||.|:||:|||
Mouse   130 YSMVGCQRAMMANRLSFFFDFKGPSIALDTACSSSLLALQNAYQAIRSGECPAALVGGINLLLKP 194

  Fly   213 IFALQFLRLGIVSHDGSCKTFDAAANGYARADTCAVVLLQRRKEAKRVYASILNVRTNTDGFKEQ 277
            ..::||::||::|.||:|::||.:.:||.|::....|||.::..|:||||:|||..|||||.|||
Mouse   195 NTSVQFMKLGMLSPDGTCRSFDDSGSGYCRSEAVVAVLLTKKSLARRVYATILNAGTNTDGSKEQ 259

  Fly   278 GVTFPDGRMQQALLEETYSEIGLNPDEVVYVEAHGSGTPVGDDQEANMLSNFFCRPSRSTPLLIG 342
            |||||.|.:|:.|:...|...||.|:.:.|:||||:||.|||.||.|.::...| ..|..|||||
Mouse   260 GVTFPSGEVQEQLICSLYQPAGLAPESLEYIEAHGTGTKVGDPQELNGITRSLC-AFRQAPLLIG 323

  Fly   343 SVKSNMGHAEPASGVSALAKMIIAMEEGIIPKNLHYRTPNPSVPALVEGKLKVVDRNLPWQGGIV 407
            |.||||||.|||||::||.|:::::|.|:...|||:..|||.:|||::|:|:||||.||.:||.|
Mouse   324 STKSNMGHPEPASGLAALTKVLLSLEHGVWAPNLHFHNPNPEIPALLDGRLQVVDRPLPVRGGNV 388

  Fly   408 GLNSFGFGGANAHVVLKSHTKAKEPKACPKAGEAEQSL-SLVTCSGRTEDAVNQLLKVATEQRHD 471
            |:|||||||:|.||:|:.:|: :.|     |..|..:| .|:..||||.:||..||:...:...|
Mouse   389 GINSFGFGGSNVHVILQPNTR-QAP-----APTAHAALPHLLHASGRTLEAVQDLLEQGRQHSQD 447

  Fly   472 QELLTLINDIHSHPIPLHPFRGYAVLGTSGCVKEEVLPYEEEERPIWFVYAGMGSQWARMAKDLM 536
            ...::::|||.:.|....|||||.|||..|.| :||......:||:||:.:|||:||..|...||
Mouse   448 LAFVSMLNDIAATPTAAMPFRGYTVLGVEGRV-QEVQQVSTNKRPLWFICSGMGTQWRGMGLSLM 511

  Fly   537 QLEVFRNSIQHCAEVLAQVDFDLIDVLTRSTERTFDNMLYSFVSVSAVQVALTDLLRVLDIRPDG 601
            :|:.||.||....|.:..:...:.|:|..:.|||||:::::|||::|:|:||.|||..:.::|||
Mouse   512 RLDSFRESILRSDEAVKPLGVKVSDLLLSTDERTFDDIVHAFVSLTAIQIALIDLLTSVGLKPDG 576

  Fly   602 IIGHSAGELGAAYMDGCLTAEQTVLAAYWRGRSVLDTPDLPRGKMAAVGLSWEQIGSQIPKDCYP 666
            |||||.||:...|.||||:..:.||||||||:.:.|. .||.|.|||||||||:...:.|....|
Mouse   577 IIGHSLGEVACGYADGCLSQREAVLAAYWRGQCIKDA-HLPPGSMAAVGLSWEECKQRCPAGVVP 640

  Fly   667 VCHNSDDNCTVSGPPSSMDAMIEDLTAKGIFVREVGSGGYAFHSPYIEGAAPMLRRSLERLITEP 731
            .||||:|..|:|||.::::..:|.|..:|:|.:||.:||.||||.::||.||.|.::|:::|.||
Mouse   641 ACHNSEDTVTISGPQAAVNEFVEQLKQEGVFAKEVRTGGLAFHSYFMEGIAPTLLQALKKVIREP 705

  Fly   732 KKKSIRWLSTSVKEAEWDSEKNHLASAGYFINNLISPVLFHQAVKRIPQNALIVEIAPHGLFRAI 796
            :.:|.||||||:.||:|.|.....:||.|.:|||:|||||.:|:..||::|:::|||||.|.:|:
Mouse   706 RPRSARWLSTSIPEAQWQSSLARTSSAEYNVNNLVSPVLFQEALWHIPEHAVVLEIAPHALLQAV 770

  Fly   797 L-RSLSPQISYVSLMQRGHANNFEFLLSQLGRLYAAGGQPQILKISPSIPYPVSRGTPMLGSLVG 860
            | |.:....:.:.||:|.|.:|.||.|:.||:::..|.......:.|.:.:|..||||::...:.
Mouse   771 LKRGVKSSCTIIPLMKRDHKDNLEFFLTNLGKVHLTGINVNPNALFPPVEFPAPRGTPLISPHIK 835

  Fly   861 WDHTQKWNYP---KFKGGRQAGQLSV-ELDLGKEE-NVYLAGHTIDGRVLFPATGYMTLAWMSLA 920
            |||:|.|:.|   .|..|..:...:| .:|...|. :.||..|.|||||:||.|||:.|.|.:||
Mouse   836 WDHSQTWDVPVAEDFPNGSSSSSATVYSIDASPESPDHYLVDHCIDGRVIFPGTGYLCLVWKTLA 900

  Fly   921 QQQGLDYLRTPVLFEDVVFHRATILSVGTVVKLTLNFFPGSSSFEICEGTSLVTSGKIRLVSNVQ 985
            :..||....|||:||:|.||:||||.....|.|.:.....|.:||:.:..:|:.|||:.|..:..
Mouse   901 RSLGLSLEETPVVFENVSFHQATILPKTGTVALEVRLLEASHAFEVSDTGNLIVSGKVYLWEDPN 965

  Fly   986 Q---EQLQLSSLPGIAGSNKLSTKDIYKELRLRGYDYTGVFQGILESDISAVTGQLQWADNWISF 1047
            .   :..::.:.|..|..::|:..::|||||||||||...||||.|:.:....|:|.|.|||::|
Mouse   966 SKLFDHPEVPTPPESASVSRLTQGEVYKELRLRGYDYGPQFQGICEATLEGEQGKLLWKDNWVTF 1030

  Fly  1048 MDTMLQFRILSNDIRELYVPTGIERALIDPLKHLELA---KKHQQKLTVNWHRNISVVKCGGVEI 1109
            ||||||..||.:..:.|.:||.:....|||..|.:..   |:..|...|...|.:.:...||:.|
Mouse  1031 MDTMLQVSILGSSQQSLQLPTRVTAIYIDPATHRQKVYRLKEDTQVADVTTSRCLGITVSGGIHI 1095

  Fly  1110 HKMKTAQTQRRSGGQSPPSLERYRFWPHSQHLGQREEQEKSRSTA----------LAVAIQLIIE 1164
            .:::|..|.||...|..|:||::.|.||      .|.:..|.|||          ||.|:|....
Mouse  1096 SRLQTTATSRRQQEQLVPTLEKFVFTPH------MEAECLSESTALQKELQLCKGLARALQTKAT 1154

  Fly  1165 NSGGAVKLKGVE-----------LAGSRSTLDALSAVQLLELIEREPILVGDMAVVTSSSNESEL 1218
            ..|....:.|.|           .|..:..|:....::|.|.:.:|.:|:.:..:::...|...|
Mouse  1155 QQGLKAAMLGQEDPPQHGLPRLLAAACQLQLNGNLQLELGEALAQERLLLPEDPLISGLLNSQAL 1219

  Fly  1219 G-------EQLKEHGIRVIVKDIKAGA------------VEQQCHFVYSVNMLAQNSVKDLQ--- 1261
            .       |.|..  :::.|.::.||.            .:......|:.......::||:|
Mouse  1220 KACVDTALENLST--LKMKVAEVLAGEGHLYSRIPALLNTQPMLQLEYTATDRHPQALKDVQTKL 1282

  Fly  1262 ----------------------------HC-----------LDSLKS---DSGFLLL-------- 1276
                                        :|           ||::.:   :.||||:
Mouse  1283 QQHDVAQGQWNPSDPAPSSLGALDLLVCNCALATLGDPALALDNMVAALKEGGFLLVHTVLKGHA 1347

  Fly  1277 ---------EEAASRYNIIGKEKLNK------LKLVSVLEQFFGTDRVLVLVRKLSKVQSSQALT 1326
                     .|.....:::.:|:...      |.||.:...|:||  .|.|.|:  .:...:.:.
Mouse  1348 LGETLACLPSEVQPAPSLLSQEEWESLFSRKALHLVGLKRSFYGT--ALFLCRR--AIPQEKPIF 1408

  Fly  1327 LHLTNKQFKWVNELKNSIAKAQAEEKNLYLVAQGEPNSGALGLMNCLKREAGGHFLRLYLI---- 1387
            |.:.:..|:||:.||:::|.:.::.  ::|.|...|.||.:||:|||::|.|||.:|..|:
Mouse  1409 LSVEDTSFQWVDSLKSTLATSSSQP--VWLTAMDCPTSGVVGLVNCLRKEPGGHRIRCILLSNLS 1471

  Fly  1388 -------LDEGVPQFSLDDPFYAAQLAK-DLVVNVYRNGSWGSYRHLKMESRPPMLPVEQAYVNT 1444
                   ||.|.|:..        |:.| |||:||||:|:||::||.::|...|......|:||.
Mouse  1472 NTSHAPKLDPGSPELQ--------QVLKHDLVMNVYRDGAWGAFRHFQLEQDKPKEQTAHAFVNV 1528

  Fly  1445 LVKGDLSSLRWIESP--RSSPIQSQLEPCTVYYAPLNFRDVMLASGKLGVDALPGDLAYQDCVLG 1507
            |.:|||:|:||:.||  .:.|..|..:.||||||.|||||:|||:|||..||:||..|.:||:||
Mouse  1529 LTRGDLASIRWVSSPLKHTQPSSSGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWASRDCMLG 1593

  Fly  1508 LEFAGRDSCGRRVMAMVTAKSLATNCLANRNLLWEVPSKWTMEQASTVPCVYATVYYALVVRGQM 1572
            :||:|||.||||||.:|.|:.|||:.|.:.:.||:|||.||:|:|::||.||.|.||:|||||::
Mouse  1594 MEFSGRDRCGRRVMGLVPAEGLATSVLLSSDFLWDVPSSWTLEEAASVPVVYTTAYYSLVVRGRI 1658

  Fly  1573 KEGERILIHAGSGGVGQAAISVALAHGLTVFTTVGSKEKREFLLKRFPKLKAKNIGNSRDTSFEQ 1637
            :.||.:|||:|||||||||||:||:.|..|||||||.|||.:|..|||:|...:..|||||||||
Mouse  1659 QRGETVLIHSGSGGVGQAAISIALSLGCRVFTTVGSAEKRAYLQARFPQLDDTSFANSRDTSFEQ 1723

  Fly  1638 LIMSETHGNGVELVLNSLSEEKLQASIRCLALNGRFLEIGKFDLSNNTPLGMSVFLKNTSFHGIL 1702
            .::..|.|.||:||||||:|||||||:||||.:||||||||||||||.||||::||||.:|||||
Mouse  1724 HVLLHTGGKGVDLVLNSLAEEKLQASVRCLAQHGRFLEIGKFDLSNNHPLGMAIFLKNVTFHGIL 1788

  Fly  1703 LDSVMEGEEEMQLMVAKLVAEGIKSGAVQPLPTTVFAEQEIEKAFRFMASGKHIGKVVIKVRLEE 1767
            ||::.|...:....||.|:..||:.|.|:||..|||.:.::|.|||:||.|||||||:::|| ||
Mouse  1789 LDALFEEANDSWREVAALLKAGIRDGVVKPLKCTVFPKAQVEDAFRYMAQGKHIGKVLVQVR-EE 1852

  Fly  1768 EQQAALPRLRQ--IQAIPRSYMHPEKSYILVGGLGGFGLELANWLVSRGARFLVLSSRSGVKSGY 1830
            |.:|.||..:.  |.||.:::....||||:.|||||||||||.|||.|||:.|||:||||:::||
Mouse  1853 EPEAVLPGAQPTLISAISKTFCPAHKSYIITGGLGGFGLELARWLVLRGAQRLVLTSRSGIRTGY 1917

  Fly  1831 QALMIRRWHDRGVQVQIDTNDVTTAVGCQRLLEVSNKLALVGGIFNLAAVLRDGLIEDQSPKNFE 1895
            ||..||.|..:|:||.:.|::|::..|.:.|:..:.||..|||:||||.||||.::|:|:|:.|:
Mouse  1918 QAKHIREWRRQGIQVLVSTSNVSSLEGARALIAEATKLGPVGGVFNLAMVLRDAMLENQTPELFQ 1982

  Fly  1896 KVSAPKLLATIHLDKISREICPALEYFVCFSSLSCGRGNMGQTNYGLANSTMERICEQRQEYGYP 1960
            .|:.||...|::||:.:||.||.|:|||.|||:||||||.||||||.||||||||||||:..|.|
Mouse  1983 DVNKPKYNGTLNLDRATREACPELDYFVAFSSVSCGRGNAGQTNYGFANSTMERICEQRRHDGLP 2047

  Fly  1961 GTAIQWGAIGDTGLIIEHMGNNETVVGGTLPQRMISCLETLDLFLQQPHPVMASMVVAEKRKTEQ 2025
            |.|:|||||||.|:::|.||.|:||:|||||||:.||:|.|||||.|||.|::|.|:|||:....
Mouse  2048 GLAVQWGAIGDVGIVLEAMGTNDTVIGGTLPQRISSCMEVLDLFLNQPHAVLSSFVLAEKKAVAH 2112

  Fly  2026 AN---RLSLIATIANIMGLRDVKSVSDKTTLFDLGMDSLMSTEIKQTLERHFDLVLSAQEIRQLT 2087
            .:   :..|:..:|:|:|:||:..::..:||.|||:||||..|::|.|||..||||..:|:||||
Mouse  2113 GDGDTQRDLVKAVAHILGIRDLAGINLDSTLADLGLDSLMGVEVRQILEREHDLVLPMREVRQLT 2177

  Fly  2088 FSALRQIDAQEPPSASVSSPSASSTLSRIKEE----ACVEVQPQSDETRKVFAKEVLPQEVMVRL 2148
            ...|:::.::...:...::|.:.|..| :|:.    :.:.|.|:.              ..:.:|
Mouse  2178 LRKLQEMSSKTDSATDTTAPKSRSDTS-LKQNQLNLSTLLVNPEG--------------PTLTQL 2227

  Fly  2149 RSKAPVASEDPAVFFLAPIEGFTIAVEALAASLTCPAYGLQCTEQVPLDSIEACAAYYLRQIQKL 2213
            .|   |.|.:..:|.:.||||.|....:|||.|:.|.||||||:..|||||...||||:..|:::
Mouse  2228 NS---VQSSERPLFLVHPIEGSTTVFHSLAAKLSVPTYGLQCTQAAPLDSIPNLAAYYIDCIKQV 2289

  Fly  2214 QPLGPYHIVGYSYGCLLAHAIAVALEQRRFGV----KVIMLDGAPTMASGYVQEAK-KQTDDLNR 2273
            ||.|||.|.|||:|..:|..:...|:.::...    .:.:.||:.|....|.|..: |.|.....
Mouse  2290 QPEGPYRIAGYSFGACVAFEMCSQLQAQQGPAPTHNNLFLFDGSHTYVLAYTQSYRAKMTPGCEA 2354

  Fly  2274 Q-QSMTLAYFGALLADVDYNQVLLQLLDGVQTWPSKLDKLADTLA--------GYTQQTREVIKK 2329
            : ::..|.:|.....||::::||..||        .|..|.|.:|        .:....|..:..
Mouse  2355 EAEAEALCFFIKQFLDVEHSKVLEALL--------PLKSLEDRVAASVDLITKSHHSLDRRELSF 2411

  Fly  2330 AACMFKQKLLLSESYKGAKQLHSDVVLIKS---AEHNAIMAQDYGLKEICSAQIDMHVVEGTHRT 2391
            ||..|..||..::.||...:.|.:|.|:::   ..:...:..||.|.::|..::.:|::||.|||
Mouse  2412 AAVSFYHKLRAADQYKPKAKYHGNVTLLRAKTGGTYGEDLGADYNLSQVCDGKVSVHIIEGDHRT 2476

  Fly  2392 FLK 2394
            .|:
Mouse  2477 LLE 2479

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.