DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FASN2 and Fasn

DIOPT Version :10

Sequence 1:NP_001259986.1 Gene:FASN2 / 117361 FlyBaseID:FBgn0042627 Length:2410 Species:Drosophila melanogaster
Sequence 2:NP_032014.3 Gene:Fasn / 14104 MGIID:95485 Length:2504 Species:Mus musculus


Alignment Length:2538 Identity:1082/2538 - (42%)
Similarity:1563/2538 - (61%) Gaps:222/2538 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 DIVISGLSGKLPESSNIEEFKYNLLNGIDMVTDEPRRWEAGIYGLPERMAKMKDSDLEKFDDKFF 82
            ::||:|:|||||||.|::||..||:.|:|||||:.|||:||:||||:|..|:|  ||.|||..||
Mouse     3 EVVIAGMSGKLPESENLQEFWANLIGGVDMVTDDDRRWKAGLYGLPKRSGKLK--DLSKFDASFF 65

  Fly    83 SVHQKQAELMDPCMRMLLELTHEAIIDAGINPVQLRGSRTGVYIGLSFVETEHEIPNMEPSSING 147
            .||.|||..|||.:|:|||:::|||:|.||||..|||:.|||::|:|..|.. |..:.:|.::.|
Mouse    66 GVHPKQAHTMDPQLRLLLEVSYEAIVDGGINPASLRGTNTGVWVGVSGSEAS-EALSRDPETLLG 129

  Fly   148 YCLTGCARAMFANRISYTFDFKGPSFIVDTACSSSLVALNHAFADMRAGRCDYALVAGVNLILKP 212
            |.:.||.|||.|||:|:.|||||||..:||||||||:||.:|:..:|:|.|..|||.|:||:|||
Mouse   130 YSMVGCQRAMMANRLSFFFDFKGPSIALDTACSSSLLALQNAYQAIRSGECPAALVGGINLLLKP 194

  Fly   213 IFALQFLRLGIVSHDGSCKTFDAAANGYARADTCAVVLLQRRKEAKRVYASILNVRTNTDGFKEQ 277
            ..::||::||::|.||:|::||.:.:||.|::....|||.::..|:||||:|||..|||||.|||
Mouse   195 NTSVQFMKLGMLSPDGTCRSFDDSGSGYCRSEAVVAVLLTKKSLARRVYATILNAGTNTDGSKEQ 259

  Fly   278 GVTFPDGRMQQALLEETYSEIGLNPDEVVYVEAHGSGTPVGDDQEANMLSNFFCRPSRSTPLLIG 342
            |||||.|.:|:.|:...|...||.|:.:.|:||||:||.|||.||.|.::...| ..|..|||||
Mouse   260 GVTFPSGEVQEQLICSLYQPAGLAPESLEYIEAHGTGTKVGDPQELNGITRSLC-AFRQAPLLIG 323

  Fly   343 SVKSNMGHAEPASGVSALAKMIIAMEEGIIPKNLHYRTPNPSVPALVEGKLKVVDRNLPWQGGIV 407
            |.||||||.|||||::||.|:::::|.|:...|||:..|||.:|||::|:|:||||.||.:||.|
Mouse   324 STKSNMGHPEPASGLAALTKVLLSLEHGVWAPNLHFHNPNPEIPALLDGRLQVVDRPLPVRGGNV 388

  Fly   408 GLNSFGFGGANAHVVLKSHTKAKEPKACPKAGEAEQSL-SLVTCSGRTEDAVNQLLKVATEQRHD 471
            |:|||||||:|.||:|:.:|: :.|     |..|..:| .|:..||||.:||..||:...:...|
Mouse   389 GINSFGFGGSNVHVILQPNTR-QAP-----APTAHAALPHLLHASGRTLEAVQDLLEQGRQHSQD 447

  Fly   472 QELLTLINDIHSHPIPLHPFRGYAVLGTSGCVKEEVLPYEEEERPIWFVYAGMGSQWARMAKDLM 536
            ...::::|||.:.|....|||||.|||..|.| :||......:||:||:.:|||:||..|...||
Mouse   448 LAFVSMLNDIAATPTAAMPFRGYTVLGVEGRV-QEVQQVSTNKRPLWFICSGMGTQWRGMGLSLM 511

  Fly   537 QLEVFRNSIQHCAEVLAQVDFDLIDVLTRSTERTFDNMLYSFVSVSAVQVALTDLLRVLDIRPDG 601
            :|:.||.||....|.:..:...:.|:|..:.|||||:::::|||::|:|:||.|||..:.::|||
Mouse   512 RLDSFRESILRSDEAVKPLGVKVSDLLLSTDERTFDDIVHAFVSLTAIQIALIDLLTSVGLKPDG 576

  Fly   602 IIGHSAGELGAAYMDGCLTAEQTVLAAYWRGRSVLDTPDLPRGKMAAVGLSWEQIGSQIPKDCYP 666
            |||||.||:...|.||||:..:.||||||||:.:.|. .||.|.|||||||||:...:.|....|
Mouse   577 IIGHSLGEVACGYADGCLSQREAVLAAYWRGQCIKDA-HLPPGSMAAVGLSWEECKQRCPAGVVP 640

  Fly   667 VCHNSDDNCTVSGPPSSMDAMIEDLTAKGIFVREVGSGGYAFHSPYIEGAAPMLRRSLERLITEP 731
            .||||:|..|:|||.::::..:|.|..:|:|.:||.:||.||||.::||.||.|.::|:::|.||
Mouse   641 ACHNSEDTVTISGPQAAVNEFVEQLKQEGVFAKEVRTGGLAFHSYFMEGIAPTLLQALKKVIREP 705

  Fly   732 KKKSIRWLSTSVKEAEWDSEKNHLASAGYFINNLISPVLFHQAVKRIPQNALIVEIAPHGLFRAI 796
            :.:|.||||||:.||:|.|.....:||.|.:|||:|||||.:|:..||::|:::|||||.|.:|:
Mouse   706 RPRSARWLSTSIPEAQWQSSLARTSSAEYNVNNLVSPVLFQEALWHIPEHAVVLEIAPHALLQAV 770

  Fly   797 L-RSLSPQISYVSLMQRGHANNFEFLLSQLGRLYAAGGQPQILKISPSIPYPVSRGTPMLGSLVG 860
            | |.:....:.:.||:|.|.:|.||.|:.||:::..|.......:.|.:.:|..||||::...:.
Mouse   771 LKRGVKSSCTIIPLMKRDHKDNLEFFLTNLGKVHLTGINVNPNALFPPVEFPAPRGTPLISPHIK 835

  Fly   861 WDHTQKWNYP---KFKGGRQAGQLSV-ELDLGKEE-NVYLAGHTIDGRVLFPATGYMTLAWMSLA 920
            |||:|.|:.|   .|..|..:...:| .:|...|. :.||..|.|||||:||.|||:.|.|.:||
Mouse   836 WDHSQTWDVPVAEDFPNGSSSSSATVYSIDASPESPDHYLVDHCIDGRVIFPGTGYLCLVWKTLA 900

  Fly   921 QQQGLDYLRTPVLFEDVVFHRATILSVGTVVKLTLNFFPGSSSFEICEGTSLVTSGKIRLVSNVQ 985
            :..||....|||:||:|.||:||||.....|.|.:.....|.:||:.:..:|:.|||:.|..:..
Mouse   901 RSLGLSLEETPVVFENVSFHQATILPKTGTVALEVRLLEASHAFEVSDTGNLIVSGKVYLWEDPN 965

  Fly   986 Q---EQLQLSSLPGIAGSNKLSTKDIYKELRLRGYDYTGVFQGILESDISAVTGQLQWADNWISF 1047
            .   :..::.:.|..|..::|:..::|||||||||||...||||.|:.:....|:|.|.|||::|
Mouse   966 SKLFDHPEVPTPPESASVSRLTQGEVYKELRLRGYDYGPQFQGICEATLEGEQGKLLWKDNWVTF 1030

  Fly  1048 MDTMLQFRILSNDIRELYVPTGIERALIDPLKHLELA---KKHQQKLTVNWHRNISVVKCGGVEI 1109
            ||||||..||.:..:.|.:||.:....|||..|.:..   |:..|...|...|.:.:...||:.|
Mouse  1031 MDTMLQVSILGSSQQSLQLPTRVTAIYIDPATHRQKVYRLKEDTQVADVTTSRCLGITVSGGIHI 1095

  Fly  1110 HKMKTAQTQRRSGGQSPPSLERYRFWPHSQHLGQREEQEKSRSTA----------LAVAIQLIIE 1164
            .:::|..|.||...|..|:||::.|.||      .|.:..|.|||          ||.|:|....
Mouse  1096 SRLQTTATSRRQQEQLVPTLEKFVFTPH------MEAECLSESTALQKELQLCKGLARALQTKAT 1154

  Fly  1165 NSGGAVKLKGVE-----------LAGSRSTLDALSAVQLLELIEREPILVGDMAVVTSSSNESEL 1218
            ..|....:.|.|           .|..:..|:....::|.|.:.:|.:|:.:..:::...|...|
Mouse  1155 QQGLKAAMLGQEDPPQHGLPRLLAAACQLQLNGNLQLELGEALAQERLLLPEDPLISGLLNSQAL 1219

  Fly  1219 G-------EQLKEHGIRVIVKDIKAGA------------VEQQCHFVYSVNMLAQNSVKDLQ--- 1261
            .       |.|..  :::.|.::.||.            .:......|:.......::||:|   
Mouse  1220 KACVDTALENLST--LKMKVAEVLAGEGHLYSRIPALLNTQPMLQLEYTATDRHPQALKDVQTKL 1282

  Fly  1262 ----------------------------HC-----------LDSLKS---DSGFLLL-------- 1276
                                        :|           ||::.:   :.||||:        
Mouse  1283 QQHDVAQGQWNPSDPAPSSLGALDLLVCNCALATLGDPALALDNMVAALKEGGFLLVHTVLKGHA 1347

  Fly  1277 ---------EEAASRYNIIGKEKLNK------LKLVSVLEQFFGTDRVLVLVRKLSKVQSSQALT 1326
                     .|.....:::.:|:...      |.||.:...|:||  .|.|.|:  .:...:.:.
Mouse  1348 LGETLACLPSEVQPAPSLLSQEEWESLFSRKALHLVGLKRSFYGT--ALFLCRR--AIPQEKPIF 1408

  Fly  1327 LHLTNKQFKWVNELKNSIAKAQAEEKNLYLVAQGEPNSGALGLMNCLKREAGGHFLRLYLI---- 1387
            |.:.:..|:||:.||:::|.:.::.  ::|.|...|.||.:||:|||::|.|||.:|..|:    
Mouse  1409 LSVEDTSFQWVDSLKSTLATSSSQP--VWLTAMDCPTSGVVGLVNCLRKEPGGHRIRCILLSNLS 1471

  Fly  1388 -------LDEGVPQFSLDDPFYAAQLAK-DLVVNVYRNGSWGSYRHLKMESRPPMLPVEQAYVNT 1444
                   ||.|.|:..        |:.| |||:||||:|:||::||.::|...|......|:||.
Mouse  1472 NTSHAPKLDPGSPELQ--------QVLKHDLVMNVYRDGAWGAFRHFQLEQDKPKEQTAHAFVNV 1528

  Fly  1445 LVKGDLSSLRWIESP--RSSPIQSQLEPCTVYYAPLNFRDVMLASGKLGVDALPGDLAYQDCVLG 1507
            |.:|||:|:||:.||  .:.|..|..:.||||||.|||||:|||:|||..||:||..|.:||:||
Mouse  1529 LTRGDLASIRWVSSPLKHTQPSSSGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWASRDCMLG 1593

  Fly  1508 LEFAGRDSCGRRVMAMVTAKSLATNCLANRNLLWEVPSKWTMEQASTVPCVYATVYYALVVRGQM 1572
            :||:|||.||||||.:|.|:.|||:.|.:.:.||:|||.||:|:|::||.||.|.||:|||||::
Mouse  1594 MEFSGRDRCGRRVMGLVPAEGLATSVLLSSDFLWDVPSSWTLEEAASVPVVYTTAYYSLVVRGRI 1658

  Fly  1573 KEGERILIHAGSGGVGQAAISVALAHGLTVFTTVGSKEKREFLLKRFPKLKAKNIGNSRDTSFEQ 1637
            :.||.:|||:|||||||||||:||:.|..|||||||.|||.:|..|||:|...:..|||||||||
Mouse  1659 QRGETVLIHSGSGGVGQAAISIALSLGCRVFTTVGSAEKRAYLQARFPQLDDTSFANSRDTSFEQ 1723

  Fly  1638 LIMSETHGNGVELVLNSLSEEKLQASIRCLALNGRFLEIGKFDLSNNTPLGMSVFLKNTSFHGIL 1702
            .::..|.|.||:||||||:|||||||:||||.:||||||||||||||.||||::||||.:|||||
Mouse  1724 HVLLHTGGKGVDLVLNSLAEEKLQASVRCLAQHGRFLEIGKFDLSNNHPLGMAIFLKNVTFHGIL 1788

  Fly  1703 LDSVMEGEEEMQLMVAKLVAEGIKSGAVQPLPTTVFAEQEIEKAFRFMASGKHIGKVVIKVRLEE 1767
            ||::.|...:....||.|:..||:.|.|:||..|||.:.::|.|||:||.|||||||:::|| ||
Mouse  1789 LDALFEEANDSWREVAALLKAGIRDGVVKPLKCTVFPKAQVEDAFRYMAQGKHIGKVLVQVR-EE 1852

  Fly  1768 EQQAALPRLRQ--IQAIPRSYMHPEKSYILVGGLGGFGLELANWLVSRGARFLVLSSRSGVKSGY 1830
            |.:|.||..:.  |.||.:::....||||:.|||||||||||.|||.|||:.|||:||||:::||
Mouse  1853 EPEAVLPGAQPTLISAISKTFCPAHKSYIITGGLGGFGLELARWLVLRGAQRLVLTSRSGIRTGY 1917

  Fly  1831 QALMIRRWHDRGVQVQIDTNDVTTAVGCQRLLEVSNKLALVGGIFNLAAVLRDGLIEDQSPKNFE 1895
            ||..||.|..:|:||.:.|::|::..|.:.|:..:.||..|||:||||.||||.::|:|:|:.|:
Mouse  1918 QAKHIREWRRQGIQVLVSTSNVSSLEGARALIAEATKLGPVGGVFNLAMVLRDAMLENQTPELFQ 1982

  Fly  1896 KVSAPKLLATIHLDKISREICPALEYFVCFSSLSCGRGNMGQTNYGLANSTMERICEQRQEYGYP 1960
            .|:.||...|::||:.:||.||.|:|||.|||:||||||.||||||.||||||||||||:..|.|
Mouse  1983 DVNKPKYNGTLNLDRATREACPELDYFVAFSSVSCGRGNAGQTNYGFANSTMERICEQRRHDGLP 2047

  Fly  1961 GTAIQWGAIGDTGLIIEHMGNNETVVGGTLPQRMISCLETLDLFLQQPHPVMASMVVAEKRKTEQ 2025
            |.|:|||||||.|:::|.||.|:||:|||||||:.||:|.|||||.|||.|::|.|:|||:....
Mouse  2048 GLAVQWGAIGDVGIVLEAMGTNDTVIGGTLPQRISSCMEVLDLFLNQPHAVLSSFVLAEKKAVAH 2112

  Fly  2026 AN---RLSLIATIANIMGLRDVKSVSDKTTLFDLGMDSLMSTEIKQTLERHFDLVLSAQEIRQLT 2087
            .:   :..|:..:|:|:|:||:..::..:||.|||:||||..|::|.|||..||||..:|:||||
Mouse  2113 GDGDTQRDLVKAVAHILGIRDLAGINLDSTLADLGLDSLMGVEVRQILEREHDLVLPMREVRQLT 2177

  Fly  2088 FSALRQIDAQEPPSASVSSPSASSTLSRIKEE----ACVEVQPQSDETRKVFAKEVLPQEVMVRL 2148
            ...|:::.::...:...::|.:.|..| :|:.    :.:.|.|:.              ..:.:|
Mouse  2178 LRKLQEMSSKTDSATDTTAPKSRSDTS-LKQNQLNLSTLLVNPEG--------------PTLTQL 2227

  Fly  2149 RSKAPVASEDPAVFFLAPIEGFTIAVEALAASLTCPAYGLQCTEQVPLDSIEACAAYYLRQIQKL 2213
            .|   |.|.:..:|.:.||||.|....:|||.|:.|.||||||:..|||||...||||:..|:::
Mouse  2228 NS---VQSSERPLFLVHPIEGSTTVFHSLAAKLSVPTYGLQCTQAAPLDSIPNLAAYYIDCIKQV 2289

  Fly  2214 QPLGPYHIVGYSYGCLLAHAIAVALEQRRFGV----KVIMLDGAPTMASGYVQEAK-KQTDDLNR 2273
            ||.|||.|.|||:|..:|..:...|:.::...    .:.:.||:.|....|.|..: |.|.....
Mouse  2290 QPEGPYRIAGYSFGACVAFEMCSQLQAQQGPAPTHNNLFLFDGSHTYVLAYTQSYRAKMTPGCEA 2354

  Fly  2274 Q-QSMTLAYFGALLADVDYNQVLLQLLDGVQTWPSKLDKLADTLA--------GYTQQTREVIKK 2329
            : ::..|.:|.....||::::||..||        .|..|.|.:|        .:....|..:..
Mouse  2355 EAEAEALCFFIKQFLDVEHSKVLEALL--------PLKSLEDRVAASVDLITKSHHSLDRRELSF 2411

  Fly  2330 AACMFKQKLLLSESYKGAKQLHSDVVLIKS---AEHNAIMAQDYGLKEICSAQIDMHVVEGTHRT 2391
            ||..|..||..::.||...:.|.:|.|:::   ..:...:..||.|.::|..::.:|::||.|||
Mouse  2412 AAVSFYHKLRAADQYKPKAKYHGNVTLLRAKTGGTYGEDLGADYNLSQVCDGKVSVHIIEGDHRT 2476

  Fly  2392 FLK 2394
            .|:
Mouse  2477 LLE 2479

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FASN2NP_001259986.1 PksD 15..>832 CDD:442550 404/815 (50%)
hot_dog 894..>1072 CDD:469797 78/180 (43%)
Rossmann-fold NAD(P)(+)-binding proteins 1263..>1429 CDD:473865 59/214 (28%)
PKS_ER 1471..1761 CDD:214840 183/289 (63%)
KR_1_FAS_SDR_x <1780..2018 CDD:187657 141/237 (59%)
PKS_PP 2031..>2083 CDD:214834 24/51 (47%)
EntF2 <2159..2409 CDD:442548 80/253 (32%)
FasnNP_032014.3 PksD 1..1353 CDD:442550 558/1369 (41%)
Acyl and malonyl transferases 429..817 172/389 (44%)
N-terminal hotdog fold. /evidence=ECO:0000255|PROSITE-ProRule:PRU01363 844..967 47/122 (39%)
C-terminal hotdog fold. /evidence=ECO:0000255|PROSITE-ProRule:PRU01363 982..1104 47/121 (39%)
KR_1_FAS_SDR_x 1311..>1518 CDD:187657 60/220 (27%)
PKS_ER 1557..1847 CDD:214840 183/289 (63%)
Enoyl reductase 1628..1856 143/228 (63%)
Beta-ketoacyl reductase 1857..2111 147/253 (58%)
KR_1_FAS_SDR_x <1869..2105 CDD:187657 140/235 (60%)
PKS_PP 2118..>2173 CDD:214834 24/54 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2181..2205 4/24 (17%)
Thioesterase 2201..2504 89/305 (29%)
Thioesterase 2235..2494 CDD:395776 80/253 (32%)

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