DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FASN2 and fasn

DIOPT Version :9

Sequence 1:NP_001259986.1 Gene:FASN2 / 117361 FlyBaseID:FBgn0042627 Length:2410 Species:Drosophila melanogaster
Sequence 2:XP_031750124.1 Gene:fasn / 100487052 XenbaseID:XB-GENE-1002983 Length:2510 Species:Xenopus tropicalis


Alignment Length:2562 Identity:1091/2562 - (42%)
Similarity:1557/2562 - (60%) Gaps:264/2562 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 DIVISGLSGKLPESSNIEEFKYNLLNGIDMVTDEPRRWEAGIYGLPERMAKMKDSDLEKFDDKFF 82
            ||||:|:||:||||:|::||..||:.|:||||::.|||:.|:||||:|..|:|  :|:|||..||
 Frog     3 DIVIAGMSGRLPESNNLQEFWDNLIQGVDMVTEDDRRWKPGLYGLPKRNGKLK--ELDKFDAAFF 65

  Fly    83 SVHQKQAELMDPCMRMLLELTHEAIIDAGINPVQLRGSRTGVYIGLSFVETEHEIPNMEPSSING 147
            .||.|||..|||.:|:|||:.:|||:||||||.:|||:.|||::|:|..|. .|..:.:|..:.|
 Frog    66 GVHPKQAHTMDPQLRLLLEICYEAIVDAGINPNELRGTNTGVWVGVSGSEA-GEAFSRDPEELLG 129

  Fly   148 YCLTGCARAMFANRISYTFDFKGPSFIVDTACSSSLVALNHAFADMRAGRCDYALVAGVNLILKP 212
            |.:|||.||||||||||.|:|||||..:||||||||:||.:|:..::.|:|:.|:|||||::|||
 Frog   130 YSMTGCQRAMFANRISYFFNFKGPSLSIDTACSSSLLALENAYKAIQHGQCNAAIVAGVNVLLKP 194

  Fly   213 IFALQFLRLGIVSHDGSCKTFDAAANGYARADTCAVVLLQRRKEAKRVYASILNVRTNTDGFKEQ 277
            ..::||::||::|.||:||:|||:.|||.|::....||:.::..|||:|::|||..:||||||||
 Frog   195 NTSVQFMKLGMLSPDGACKSFDASGNGYCRSEAAVAVLVTKKSLAKRLYSTILNAGSNTDGFKEQ 259

  Fly   278 GVTFPDGRMQQALLEETYSEIGLNPDEVVYVEAHGSGTPVGDDQEANMLSNFFCRPSRSTPLLIG 342
            |||||.|.:||.||...|.|.|::|.:|.|:||||:||.|||.||.|.:....|..:|. |||||
 Frog   260 GVTFPSGAVQQELLTSLYKEAGIHPSQVEYLEAHGTGTKVGDPQEVNGIVGVLCDSTRE-PLLIG 323

  Fly   343 SVKSNMGHAEPASGVSALAKMIIAMEEGIIPKNLHYRTPNPSVPALVEGKLKVVDRNLPWQGGIV 407
            |.||||||.|||||::||||:|:::|.|:...||||.|||..:|||.:|:::||.:..|.:||||
 Frog   324 STKSNMGHPEPASGLAALAKVILSLEHGVWAPNLHYETPNSDIPALQDGRIQVVTKPTPVKGGIV 388

  Fly   408 GLNSFGFGGANAHVVLKSHTKAKEPKACPKAGEAEQSLSLVTCSGRTEDAVNQLLKVATEQRHDQ 472
            |:|||||||:|.|::||.:.|.      |....:.:...||...||||.||..:::.:.|...|.
 Frog   389 GINSFGFGGSNVHIILKPNEKK------PSDVASVEFPRLVLACGRTEKAVESIIQKSREPAADN 447

  Fly   473 ELLTLINDIHSHPIPLHPFRGYAVLGTSGCVKEEVLPYEEEERPIWFVYAGMGSQWARMAKDLMQ 537
            ..:||:|||...|....|:|||.:..|...:| |:...:...||:|::.:|||:||..|...||:
 Frog   448 TFVTLLNDISGIPQSSMPYRGYTLAKTDSDIK-EIQQAQVSGRPLWYICSGMGTQWKGMGHSLMK 511

  Fly   538 LEVFRNSIQHCAEVLAQVDFDLIDVLTRSTERTFDNMLYSFVSVSAVQVALTDLLRVLDIRPDGI 602
            |::||.||....|.|......:.::|..:.:|||::.|::||.::|:|||..|:|:.:.:.||||
 Frog   512 LDIFRQSILRSDEALKGTGLKVSELLLNADDRTFEDTLHAFVGLAAIQVAQIDMLKAMKLEPDGI 576

  Fly   603 IGHSAGELGAAYMDGCLTAEQTVLAAYWRGRSVLDTPDLPRGKMAAVGLSWEQIGSQIPKDCYPV 667
            :|||.|||...|.|..|:..:.:||||||||.:.:. .||.|.||||||:|.:...|.||...|.
 Frog   577 VGHSVGELACGYADNSLSQNEAILAAYWRGRCIKEA-HLPPGGMAAVGLTWAECKIQCPKGVVPA 640

  Fly   668 CHNSDDNCTVSGPPSSMDAMIEDLTAKGIFVREVGSGGYAFHSPYIEGAAPMLRRSLERLITEPK 732
            ||||:|..|:|||..|:...:..|.:||:|.:||.|.|.||||.|:|..||.|..:|:::|| ||
 Frog   641 CHNSEDTVTISGPQDSVREFVGSLKSKGVFAKEVQSAGVAFHSYYMESIAPSLLNALKKIIT-PK 704

  Fly   733 KKSIRWLSTSVKEAEWDSEKNHLASAGYFINNLISPVLFHQAVKRIPQNALIVEIAPHGLFRAIL 797
            .:|.||:|||:.|::|:|.....:||.|.:|||:|||||.:.::.||:||::||||||.|.:|:|
 Frog   705 PRSSRWVSTSIPESQWNSNLAKFSSAEYHVNNLVSPVLFQEGLQNIPENAVVVEIAPHALLQAVL 769

  Fly   798 -RSLSPQISYVSLMQRGHANNFEFLLSQLGRLYAAGGQPQILKISPSIPYPVSRGTPMLGSLVGW 861
             |||.|..:.:.||::||:||.||.|:.:|::|..|...:...|.||:.||...||.::..|:.|
 Frog   770 RRSLKPTNTILPLMKKGHSNNLEFFLTNIGKVYMNGINVEANNIFPSVEYPAPAGTSLISPLIMW 834

  Fly   862 DHTQKWNYPKFK------GGRQAGQLSVELDLGKEE-NVYLAGHTIDGRVLFPATGYMTLAWMSL 919
            ||:|.|:.||.:      ||..|..: ..:|:..:. ::::.||.||||||:|||||:.|||.:|
 Frog   835 DHSQTWDVPKAEDFPAGSGGSTATTV-YNIDMNPDSPDLFMNGHCIDGRVLYPATGYLVLAWRTL 898

  Fly   920 AQQQGLDYLRTPVLFEDVVFHRATILSVGTVVKLTLNFFPGSSSFEICEGTSLVTSGKIRL---- 980
            |:..|:...:|||:||||..||||||....::::.:...|.|..||:.|..||..||||.:    
 Frog   899 ARSLGIVMEQTPVIFEDVTIHRATILPKTGIIQMEVRLMPASKRFEVSENGSLTASGKISVMEEN 963

  Fly   981 VSNVQQEQL--QLSSLPGIAGSNKLSTKDIYKELRLRGYDYTGVFQGILESDISAVTGQLQWADN 1043
            |.|..|.||  .|.....|.....||.:|||||||||||||...||||:||:.....|:|.|:.|
 Frog   964 VLNNFQNQLMDSLDKDEDIDSELPLSDRDIYKELRLRGYDYGPSFQGIIESNSRGDKGKLLWSGN 1028

  Fly  1044 WISFMDTMLQFRILSNDIRELYVPTGIERALIDPLKHLELAKKHQQKLTVNWHR---NISVVKC- 1104
            |::|.|||||..:|....|.|.:||.|....|||..|.:....|      |..|   :::|..| 
 Frog  1029 WVTFTDTMLQMMVLGLKGRSLRLPTRILSVGIDPTIHKDHVFLH------NGDREAVHVAVNSCL 1087

  Fly  1105 -----GGVEIHKMKTAQTQRRSGGQSPPSLERYRFWPH--------------------------- 1137
                 |||:|..:......||...|:||.||::.|.|:                           
 Frog  1088 DRIVAGGVQILGLHATTAPRRQQQQTPPILEKFVFTPYFEEKCLSDNHDLHYQLQQCSGKIRDLE 1152

  Fly  1138 ---SQHLGQREE------------------------------------------------QEKSR 1151
               ||| |.:.|                                                :||.:
 Frog  1153 SKLSQH-GLKLEIPEFNVPEPTNEGTKSDALNKGLLHVLTEICNLELNGNLQSDLELMLIKEKDQ 1216

  Fly  1152 ------------STALAVAIQLIIENSGGAVKLKGVELAGSRSTLDALSAVQLLELIEREPILVG 1204
                        |..|...:.:::|| |...::|.||:......|  .|.|.  .|:..:|:|..
 Frog  1217 LRNDPLLNGLLDSPQLKTCLDIVLEN-GNPQQMKIVEVLAETGRL--FSYVP--TLLNTQPMLQL 1276

  Fly  1205 DMAVVTSSSNE--SELGEQLKEHGIRVIVKDIKAGAVEQQCHFVYSVNMLAQNSV--KDLQHCLD 1265
            |. :.|.|:.|  ..|.|.|||.|:          :|||     :.....|.|:|  .||..|..
 Frog  1277 DY-IATDSTTEVLLSLEENLKEFGV----------SVEQ-----WDPLGTAPNTVTNADLLVCNS 1325

  Fly  1266 SLK----------------SDSGFLLLEEAASRYNIIG-----------------------KEKL 1291
            ||.                .:.||:|| ....:.:::|                       ||..
 Frog  1326 SLHLLKNPLQAFTNMAATVKEGGFILL-HTLLKGDMLGETITFLNNQNPQQNEGLLSQTEWKEVF 1389

  Fly  1292 N--KLKLVSVLEQFFGTDRVLVLVRKLSKVQSSQALTLHLTNKQFKWVNELKNSIAKAQAEEKNL 1354
            :  .|.|:::.:.|:.:  |:.|.|:  :|.....|.|.:.:....||..::.  |.|.:.|:.:
 Frog  1390 DGASLNLIAMKKSFYNS--VIFLCRR--QVPEQTPLFLSVEDMACTWVKSVQE--AMADSGEQTI 1448

  Fly  1355 YLVAQGEPNSGALGLMNCLKREAGGHFLRLYLILD-EGVPQFSLDDPFYAAQLAKDLVVNVYRNG 1418
            :.||:.:.|||.:|::|||::|.||..:|.....| |..|   |.:.....||..|||:||||:|
 Frog  1449 WFVAENQANSGTVGMVNCLRQEPGGKRIRCIFNADAEAKP---LSEKEKKQQLTNDLVMNVYRDG 1510

  Fly  1419 SWGSYRHLKMESRPPMLPVEQAYVNTLVKGDLSSLRWIESPRSS--PIQSQLEPCTVYYAPLNFR 1481
            .|||:||:.............|:||.|.:||||:|.|:.||...  |....::.|.||||.||||
 Frog  1511 EWGSFRHIPFHKDGIQDETAFAFVNILTRGDLSTLSWVASPLQHFLPSNPNVQLCKVYYASLNFR 1575

  Fly  1482 DVMLASGKLGVDALPGDLAYQDCVLGLEFAGRDSCGRRVMAMVTAKSLATNCLANRNLLWEVPSK 1546
            |:|||:|||..||:|||||.|.|:||:||:|||..|:|||.::.||.|||...|::..||:||..
 Frog  1576 DIMLATGKLPPDAIPGDLALQQCMLGMEFSGRDPAGKRVMGLLPAKGLATAVDADQRFLWDVPES 1640

  Fly  1547 WTMEQASTVPCVYATVYYALVVRGQMKEGERILIHAGSGGVGQAAISVALAHGLTVFTTVGSKEK 1611
            |::|:|::||.||||.||||||||::::||.:|||:||||||||||::||:.|..||.||||.:|
 Frog  1641 WSLEEAASVPVVYATAYYALVVRGRIRKGESVLIHSGSGGVGQAAIAIALSMGCQVFITVGSSQK 1705

  Fly  1612 REFLLKRFPKLKAKNIGNSRDTSFEQLIMSETHGNGVELVLNSLSEEKLQASIRCLALNGRFLEI 1676
            ||:|..||.:|.|....|||||||||.|:|.|.|.||:|:||||:|||||||:||||.:||||||
 Frog  1706 REYLQNRFTELDANCFANSRDTSFEQHILSRTGGKGVDLILNSLAEEKLQASLRCLARHGRFLEI 1770

  Fly  1677 GKFDLSNNTPLGMSVFLKNTSFHGILLDSVMEGEEEMQLMVAKLVAEGIKSGAVQPLPTTVFAEQ 1741
            ||:|||||:||||::||||.||||||||::.|.:.:....|:.|:..|||.|.|:||..|||...
 Frog  1771 GKYDLSNNSPLGMALFLKNVSFHGILLDALFEDQNKEWEEVSDLLKAGIKDGVVKPLKCTVFERD 1835

  Fly  1742 EIEKAFRFMASGKHIGKVVIKVRLEEEQQAALPRLRQIQAIPRSYMHPEKSYILVGGLGGFGLEL 1806
            ::|.||||||.|||||||:||||.||.:|.....:.||.||||:.....||||:.||||||||||
 Frog  1836 DVEPAFRFMAQGKHIGKVLIKVRDEEAEQHYKSDILQISAIPRTSFPSTKSYIITGGLGGFGLEL 1900

  Fly  1807 ANWLVSRGARFLVLSSRSGVKSGYQALMIRRWHDRGVQVQIDTNDVTTAVGCQRLLEVSNKLALV 1871
            |.||:.|||:.|||:|||||::||||..|:.|...|::|.:...||.:.....:|:|.:.:|..|
 Frog  1901 AQWLIERGAKNLVLTSRSGVRNGYQAKQIQTWKGMGIKVLVSGKDVGSLEETLQLIEEAGQLGPV 1965

  Fly  1872 GGIFNLAAVLRDGLIEDQSPKNFEKVSAPKLLATIHLDKISREICPALEYFVCFSSLSCGRGNMG 1936
            |||||||.||:|.:||:.:.:.|:.|:.||...|::||::|||.||.|::||.|||:||||||.|
 Frog  1966 GGIFNLAMVLKDAMIENLTTQLFQDVNKPKYDGTLNLDRVSREKCPELDHFVAFSSVSCGRGNAG 2030

  Fly  1937 QTNYGLANSTMERICEQRQEYGYPGTAIQWGAIGDTGLIIEHMGNNETVVGGTLPQRMISCLETL 2001
            |:|||.||||||||||:|:....||.|:|||||||.|:::|.||:|:||:|||||||::||:|.|
 Frog  2031 QSNYGFANSTMERICEKRRRDNLPGLAVQWGAIGDVGVVLETMGSNDTVIGGTLPQRIVSCMEVL 2095

  Fly  2002 DLFLQQPHPVMASMVVAEKR---KTEQANRLSLIATIANIMGLRDVKSVSDKTTLFDLGMDSLMS 2063
            |.||.||||||:|.|:|||.   |::.:::..|:..:|:|:|:||:.|::..|||.|||:||||.
 Frog  2096 DQFLNQPHPVMSSFVLAEKTLSVKSKGSSQQDLVEAVAHILGVRDINSLNPDTTLADLGLDSLMG 2160

  Fly  2064 TEIKQTLERHFDLVLSAQEIRQLTFSALRQIDAQEPPSASVSSPSASST---LSRIKEEACVEVQ 2125
            .|::|||||.:|:|::.:|:||||.:.||::.::........|...||.   || |.:...:.|.
 Frog  2161 VEVRQTLERDYDIVMAMREVRQLTINKLRELSSKPSTMEDAKSTQKSSVPPELS-ILDLTNLLVN 2224

  Fly  2126 PQSDETRKVFAKEVLPQEVMVRLRSKAPVASEDPAVFFLAPIEGFTIAVEALAASLTCPAYGLQC 2190
            |.:..|.|:                 ..|.:::..:|.:.||||.|.|..:||:.|..|.|||||
 Frog  2225 PDASTTTKL-----------------NNVETDERPLFLVHPIEGSTAAFHSLASKLAIPCYGLQC 2272

  Fly  2191 TEQVPLDSIEACAAYYLRQIQKLQPLGPYHIVGYSYGCLLAHAIAVALEQRRFGVK----VIMLD 2251
            |...|||||.:.|:||.:.|:::||.|||.|.|||:|..:|..:...|:.:|...:    :.:.|
 Frog  2273 TRAAPLDSIYSLASYYNQCIKQIQPEGPYLIAGYSFGACVAFEMCSQLQAQREASQAPDSLFLFD 2337

  Fly  2252 GAPTMASGYVQ----------EAKKQTDDLNRQQSMTLAYFGALLADVDYNQVLLQLLDGVQTWP 2306
            |:.:..:.|.|          ||:.:|:        .|..|......::||:::..||. ::...
 Frog  2338 GSHSYVAAYTQSYRAKLTPGSEAEAETE--------ALCAFIQQFTGMEYNKLVEALLP-LKDLE 2393

  Fly  2307 SKLDKLADTLA-GYTQQTREVIKKAACMFKQKLLLSESYKGAKQLHSDVVLIKS---AEHNAIMA 2367
            |::....:.:. .:...::|.::.||..|..||..::.|....:...:|.|:::   .|:...:.
 Frog  2394 SRVISAVNLITQSHKDISQEALQFAASSFFYKLKAADQYIPKNKYQGNVTLLRAKTRTEYGEGLG 2458

  Fly  2368 QDYGLKEICSAQIDMHVVEGTHRTFLK 2394
            .||.|.|:|..::.:||:||.|||||:
 Frog  2459 IDYRLSEVCDGKVSVHVIEGDHRTFLE 2485

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FASN2NP_001259986.1 PksD 15..1043 CDD:225858 495/1038 (48%)
PKS 18..423 CDD:238429 228/404 (56%)
KAsynt_C_assoc 381..498 CDD:292814 47/116 (41%)
Acyl_transf_1 518..835 CDD:298668 145/317 (46%)
hot_dog 875..1072 CDD:294345 91/203 (45%)
NADB_Rossmann 1263..>1429 CDD:304358 56/207 (27%)
PKS_ER 1471..1761 CDD:214840 182/289 (63%)
enoyl_red 1473..1761 CDD:176179 181/287 (63%)
KR_1_FAS_SDR_x <1780..2018 CDD:187657 137/237 (58%)
PKS_PP 2031..>2083 CDD:214834 25/51 (49%)
Abhydrolase 2159..2408 CDD:304388 77/254 (30%)
fasnXP_031750124.1 PKS 2..404 CDD:238429 228/404 (56%)
KAsynt_C_assoc 362..471 CDD:406579 47/114 (41%)
Acyl_transf_1 492..808 CDD:395567 145/317 (46%)
hot_dog 871..1111 CDD:412416 103/245 (42%)
Methyltransf_12 1251..1350 CDD:400515 30/118 (25%)
NADB_Rossmann 1326..>1519 CDD:419666 55/202 (27%)
PKS_ER 1565..1855 CDD:214840 182/289 (63%)
KR_1_FAS_SDR_x <1853..2112 CDD:187657 147/258 (57%)
PKS_PP 2125..>2180 CDD:214834 25/54 (46%)
Thioesterase 2241..2500 CDD:395776 77/254 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 348 1.000 Domainoid score I1030
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H55800
Inparanoid 1 1.050 2041 1.000 Inparanoid score I50
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D19161at2759
OrthoFinder 1 1.000 - - FOG0001625
OrthoInspector 1 1.000 - - otm47538
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X4095
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.060

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