DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FASN2 and fasn2

DIOPT Version :9

Sequence 1:NP_001259986.1 Gene:FASN2 / 117361 FlyBaseID:FBgn0042627 Length:2410 Species:Drosophila melanogaster
Sequence 2:NP_001041530.1 Gene:fasn2 / 100000781 ZFINID:ZDB-GENE-041210-242 Length:2105 Species:Danio rerio


Alignment Length:2436 Identity:583/2436 - (23%)
Similarity:970/2436 - (39%) Gaps:649/2436 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 EDADIVISGLSGKLPESSNIEEFKYNLLNGIDMVTDEPR-RWEAGIYGLPERMAKMKD------- 71
            :|.:|.|.|:....|....:|.|...||.|.:.....|. |:....:..||.....|.       
Zfish     3 DDTEIAIVGVGCHFPGGEGLENFWRVLLEGKNCAVQIPNDRFNLSQWYDPEESKAGKTYTAKAAL 67

  Fly    72 -SDLEKFDDKFFSVHQKQAELMDPCMRMLLELTHEAIIDAGINPVQLRGSRTGVYIGLSFVETEH 135
             ..|..||.|||.:.:.::..|||..::||:.|:.|:.||||...:..|:|||||:||...:.|.
Zfish    68 IDGLNAFDHKFFGITEAESLSMDPQHKLLLQCTYRALEDAGIPMEKASGTRTGVYLGLMNRDFEL 132

  Fly   136 EIPNMEPSSINGYCLTGCARAMFANRISYTFDFKGPSFIVDTACSSSLVALNHAFADMRAGRCDY 200
            ......|..|:....||.|.::.||||||.|:|.|||..:|.|||||||||:.|...::.|.||.
Zfish   133 ATVRNNPKHISHTTGTGVAMSIAANRISYIFNFTGPSVAIDCACSSSLVALHFACQAIKQGDCDM 197

  Fly   201 ALVAGVNLILKPIFALQFLRLGIVSHDGSCKTFDAAANGYARADTCAVVLLQRRKEA----KRVY 261
            ::..||:.||:|...:...:..::|.||:.|.|.:.|:||.|.:.|.||||:..|.|    ..::
Zfish   198 SVCGGVSCILEPALFVALSKAKMISPDGTSKPFSSKADGYGRGEGCGVVLLKPLKRALEDHDHIW 262

  Fly   262 ASILNVRTNTDGFKEQGVTFPDGRMQQALLEETYS-EIGLNPDEVVYVEAHGSGTPVGDDQEANM 325
            ..|.....|.||.....:|.|....|:.||.:.|| |..|  ..|.|:||||:||||||..||..
Zfish   263 GVIGKTAVNQDGHSVSPITKPSMVQQEELLRKIYSTEADL--CSVQYIEAHGTGTPVGDPVEAGS 325

  Fly   326 LSNFFC--RPSRSTPLLIGSVKSNMGHAEPASGVSALAKMIIAMEEGIIPKNLHYRTPNPSVPAL 388
            :|....  |..:|.||:|||||||:||.|.|:||:.|.|:::.|:...|..:|.|...|.|:   
Zfish   326 MSKVIAKERSQKSGPLIIGSVKSNIGHTESAAGVAGLIKVLLMMQHETIVPSLFYSKENSSI--- 387

  Fly   389 VEGKLKVVDRNLP-----W-----QGGIVGLNSFGFGGANAHVVLKSHTKAKEPKACPKAGEAEQ 443
               .||.::.|:|     |     .|.|.|:|:|||||.|||.::|.:.::|:||:.|    ..:
Zfish   388 ---DLKSLNMNIPTRVQKWISNNRAGRIAGINNFGFGGTNAHAIVKQYVQSKKPKSQP----ISK 445

  Fly   444 SLSLVTCSGRTEDAVNQLLKVATEQRHDQELLTLINDIHSHPIPLHPFRGYAVLGTSGCVKEEV- 507
            |......|..:|.::..:::    ...||.....|:|:.|            :|.||.|.:..: 
Zfish   446 SCQYFVVSAASEKSMRNIIR----DTADQIGAGKISDLQS------------LLYTSACRRSHLK 494

  Fly   508 --------------------------LPYEEEERPIWFVYAGMGSQWARMAKDLMQLE-VFRNSI 545
                                      |...:.:..:.||:.|.|..:..|.:.|::.| |||..|
Zfish   495 HKYRNAFQTSSLADLQDKLTAAVDKRLVLSKTDSRVVFVFCGNGVTYQGMCQQLLKHETVFREEI 559

  Fly   546 QHCAEVLAQV--DFDLIDVLTRSTERTFDNMLYSFVS--VSAVQVALTDLLRVLDIRPDGIIGHS 606
            .. .|.|.::  ..:||::|...:|.:.|......|.  :.|:|||:..||:...|.||.::|||
Zfish   560 VK-IETLLKIYRRQNLIEMLEGRSEMSKDLSDPQLVQPLLFAIQVAVFKLLKHWGISPDAVLGHS 623

  Fly   607 AGELGAAYMDGCLTAEQTVLAAYWRGRSVLDTPDLPRGKMAAV-GLSWEQIGSQIPKDCYPVC-- 668
            .||:.||:..|.|:.|..|...::|. |:..|  :..|||..| .::..:|.:.:|.....||  
Zfish   624 IGEVAAAHCSGLLSLEDAVKVIHYRS-SLQST--VTGGKMLVVSNMAVSEILNMLPSHSGRVCLA 685

  Fly   669 -HNSDDNCTVSGPPSSMDAMIEDLTA----KGIFVR--EVGSGGYAFHSPYIEGAAPMLRRSLER 726
             :||..:||:||..:.:|::.:.|::    |.:|:|  :|.:   |:||..::   |::.|    
Zfish   686 AYNSPQSCTLSGDAAEIDSLHQKLSSSTNGKDLFLRILDVPA---AYHSHMMD---PIVSR---- 740

  Fly   727 LITEPKKKSIRWLSTSVKEAEWDSEKNHLASAG-------YFINNLISPVLFHQAVK---RIPQN 781
                 .|:.|..|.|...|.|..|....::|..       |:..|:...|.|.||||   :..:|
Zfish   741 -----VKEDIGSLQTCDLEMELFSTVTGVSSCSTDFITGEYWARNIRQAVEFEQAVKSATKNKRN 800

  Fly   782 ALIVEIAP-HGLFRAILRSLSPQISYVSLMQ--RGHANNFEFLLSQLGRLYAAGGQPQILKISPS 843
            .:.|||.| ..|.|.|..:|...|:.|..:|  :.|    |.:|:.:.:|:.             
Zfish   801 VIFVEIGPRRSLQRYITETLGKDIAVVPAVQPDKDH----ETMLAVVSKLFE------------- 848

  Fly   844 IPYPVSRGTPMLGSLVGWDHTQK-WN-----YPKF--------------------KGGRQAGQLS 882
                       ||:.:.||...| |.     :|::                    :......|:|
Zfish   849 -----------LGANINWDLFYKGWEAEPIPFPRYQFDDVKREVFASDLQLTGTTRNHPVVTQMS 902

  Fly   883 VE-----LDLGKEENVYLAGHTIDGRVLFPATGYMTL---AWMSLAQQQ-GLDYLRTPVLFEDVV 938
            .:     .||..|...:|..|..:|..:.|...|..|   .:|..|:.: .|..|:..:.|:..:
Zfish   903 TDSSVFSCDLSSESVAFLQDHKHNGVAIIPGAFYTELGLATFMEYAKPKVPLSSLQLSITFQSPL 967

  Fly   939 FHRATILSVGTVVKLTL-NFFPGSSSFEICEGTSLVTSGKIRLVSNVQQEQLQLSSLPGIAG--S 1000
                |.......:|:.| |......:|:|...:::...|.:.:....:.|: |..||..|:.  :
Zfish   968 ----TFTQNAPHIKVQLENLADSMHNFKIHSTSAVYAFGSVEVQPGRRPEE-QFISLDSISRRCT 1027

  Fly  1001 NKLSTKDIYKELRLRGYDYTGVFQGILESDISAVTGQLQWADNWISFMDTMLQFRILSNDIRELY 1065
            ..:::::.||:|...|:.|..||:.  ::|:                        ....:.||. 
Zfish  1028 LHMTSEEFYKQLSQTGFQYGSVFRN--KADV------------------------YCGEEFREA- 1065

  Fly  1066 VPTGIERALIDPLKHLELAKKHQQKLTVNWHRNISVVKCGGVEIHKMKTAQTQRRSGGQSPPSLE 1130
                                             :||||.....:|::                  
Zfish  1066 ---------------------------------LSVVKVPKELLHQL------------------ 1079

  Fly  1131 RYRFWPHSQHLGQREEQEKSRSTALAVAIQLIIENSGGAVKLKGVELAGSRSTLDALSAVQLLEL 1195
                  |..||.             .|.:...::       |..|.|...:|......| |:..|
Zfish  1080 ------HDYHLH-------------PVVLDYFMQ-------LAPVTLGNDQSARPQFPA-QIASL 1117

  Fly  1196 IEREPILVGDMAVVTSSSNESELGEQL------KEHGIRVIVKDIK------AGAVEQQCHFVYS 1248
            ...|| |..::.|...:.:..:.|.::      |:..:.|.:|.:|      ...|.::..|..|
Zfish  1118 TVFEP-LQEELVVYLRAVDVGDDGFEICGCLANKQGRVLVEIKHVKIKMIGSRSEVVKEYFFHNS 1181

  Fly  1249 VNMLAQNSVKD-----------------LQHCLDSLK-----SDSGFLLLEEAASRYNIIGKEK- 1290
            .::::::.:.|                 ||..|||..     |||..||  |.       |.|. 
Zfish  1182 FDIISEDDMLDTQIKALVFSDQLGIFKALQQHLDSRSRCVSFSDSSTLL--EG-------GVETL 1237

  Fly  1291 LNKLKLVSVLEQ-----FFGTDRVLVLVRKLSKVQSSQALTLHLTNKQFKWVNELK--------- 1341
            |:||.:.||.:.     |..:|..|..:.. .||..|.|....:..|..:::..|:         
Zfish  1238 LSKLAISSVKKNFQEILFMWSDADLTTLES-EKVLESMAGCCEMFRKTVRYLKALQFPGVIRVIT 1301

  Fly  1342 --------NSI------------AKAQAEEKNLYLVAQGEPNSGALGLMNCLKREAGGHFLRLY- 1385
                    :||            ..|:.:|.:..|:..|...|..:        :|....||.| 
Zfish  1302 YRSSESIVDSINPGYVLTGMTRACAAELQELSFQLIDMGSGTSEDI--------KALVQVLRSYP 1358

  Fly  1386 ------LILDEG---VPQFSLDD-PFYAAQLAKDLVVNVYRNGSWGSYRHLKMESRPPMLPVEQA 1440
                  |::.||   .|:.:... |..|:.|.|..:::                        |:.
Zfish  1359 CHKYPELVVKEGNILQPEITHTPLPSMASPLQKVHMLD------------------------EEL 1399

  Fly  1441 YVNTLVKGDLSSLRWIESPRSSPIQSQLEPCTVYYAPLNFRDVMLASGKLGVDALP---GDLAY- 1501
            ::  |...|..::|.:.   ::.:::.::|....:..|:...:.:.|.    |..|   .||:| 
Zfish  1400 FI--LQTSDPYAMRNLS---ATEMENSIQPIQGKHVELHLNKICVHSS----DYFPVSMSDLSYG 1455

  Fly  1502 -----------QDCVLGLEFAG----------RDSCGRRVMAM--VTAKS-----LATNCLANRN 1538
                       ...:|.|:::|          :...|..|::.  |:|.|     .|..|.|.| 
Zfish  1456 HTLYWNKHTSQHHNLLALDYSGTVTAVGKDVSKFKVGDHVVSCYPVSATSKVVIPAAVCCKAKR- 1519

  Fly  1539 LLWEVPSKWTMEQASTVPCVYATVYYALVVRGQMKEGERILIHAGSGGVGQAAISVALAHGLTVF 1603
                      :...:.:|||   .|..|...         ::|       :|...:.:...|.:|
Zfish  1520 ----------LSFLNDIPCV---SYMVLAWE---------ILH-------KALPKIKVQRKLGIF 1555

  Fly  1604 TTVGSKEKREFLLKRFPKLKAKNIGNSRD------TSFEQLI--MSETHGNGVELVLNSLSEEKL 1660
            :||........||.         |.|...      |..:||.  .||..| .|.|...:|...::
Zfish  1556 STVPDSALINVLLA---------IANRSGWNVKVCTQTDQLSCDFSEVVG-AVFLPPYNLVTAEV 1610

  Fly  1661 QASIRCLALNGRFLEIGKFDLSNNT--PLGMSVFLKNTS----FHGILLDSVMEGEEEMQLMVAK 1719
            .:.|:  .:|...     |...|.|  ||..:.| ::|:    ||.:.:..|:: :..:|..:.|
Zfish  1611 ASRIK--GINDIV-----FVCDNQTEVPLNSATF-RSTNEEVHFHFVFMSQVLQ-KWSLQTQMPK 1666

  Fly  1720 LV-----------AEGIKSGAVQPLPTTVFAEQEIEKAFRFMASGKHIGKVVIK----------- 1762
            :.           :..:.:.|||                  .|:.:||..:.:|           
Zfish  1667 IYRWQKSMHLNRKSMSLDTTAVQ------------------RANSQHIDLLSVKESDSYFTCQIL 1713

  Fly  1763 ----VRLEEEQQAALPRLRQIQAIPRSYMHPEKS-YILVGGLGGFGLELANWLVSRGARFLVLSS 1822
                :..|::.|     |.:|..||::.:..:|| ||:.|||.|.|.|...::..:|...:|:.|
Zfish  1714 PIIILNSEDKNQ-----LSEIPVIPKNNLFKKKSVYIVTGGLTGLGFETVKFIAQKGGEHIVILS 1773

  Fly  1823 RSGVKSGYQALMIRRWHDRGVQVQIDTNDVTTAVGCQRLLEVSNKL---ALVGGIFNLAAVLRDG 1884
            |.......|..:.:.....|..::....||:.:....:.:....||   :.:.|:|:.|.||.||
Zfish  1774 RRNPNPEMQQEISQLSSRCGSVIKSLPCDVSVSEQVDQTIAKVKKLFPSSPIKGVFHSAVVLHDG 1838

  Fly  1885 LIEDQSPKNFEKVSAPKLLATIHLDKISREICPALEYFVCFSSLSCGRGNMGQTNYGLANSTMER 1949
            |||......:|||..||:...|:|.:.:.: | .|:||||:||:|...||..||||..||:.|:.
Zfish  1839 LIERLDKSLYEKVMRPKVNGVINLHRATIQ-C-NLDYFVCYSSISAFMGNASQTNYAAANTFMDT 1901

  Fly  1950 ICEQRQEYGYPGTAIQWGAIGDTGLIIEHMGNNETV-VGGTLPQRMISCLETLD--LFLQQPHPV 2011
            .|:.|:..|..|.:|.|||: :.||:::.:.....: ..|.|...:....|:|:  |.:.:|..|
Zfish  1902 FCQYRRNIGLAGQSINWGAL-NLGLLLDKVHFQRFLEAKGILLLEVPEIHESLEQCLLINKPQQV 1965

  Fly  2012 MASM-------VVAEKRKTEQANRLSLIATIANIMG-------------------LR-------- 2042
            :...       .|..:.|:..| ||..||..|.|..                   ||        
Zfish  1966 VCRFSFKNSWNSVLSQNKSLNA-RLFKIAKEAFIRAGVNPSRPEQPMTSSSPHDYLRFLISETAG 2029

  Fly  2043 -DVKSVSDKTTLFDLGMDSLMSTEIKQTLERHFDLVLSAQEIRQLTFSALRQIDAQEPPSASVSS 2106
             :...:||...||:||:||:::    .||:.|.             || .|.::.   |..::..
Zfish  2030 VEKDELSDDVHLFELGIDSMLA----MTLQNHI-------------FS-YRGVNI---PLVTLLD 2073

  Fly  2107 PSAS-STLSRIKEEACV-EVQPQSDETRKVF 2135
            |::: ||:::|.||..| |.|..|.|:...:
Zfish  2074 PNSTLSTITKILEENGVDEYQSASYESTSTY 2104

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FASN2NP_001259986.1 PksD 15..1043 CDD:225858 322/1146 (28%)
PKS 18..423 CDD:238429 161/430 (37%)
KAsynt_C_assoc 381..498 CDD:292814 32/126 (25%)
Acyl_transf_1 518..835 CDD:298668 99/344 (29%)
hot_dog 875..1072 CDD:294345 38/208 (18%)
NADB_Rossmann 1263..>1429 CDD:304358 44/216 (20%)
PKS_ER 1471..1761 CDD:214840 63/346 (18%)
enoyl_red 1473..1761 CDD:176179 63/344 (18%)
KR_1_FAS_SDR_x <1780..2018 CDD:187657 74/251 (29%)
PKS_PP 2031..>2083 CDD:214834 17/79 (22%)
Abhydrolase 2159..2408 CDD:304388
fasn2NP_001041530.1 PksD 3..971 CDD:225858 303/1046 (29%)
PKS 5..429 CDD:238429 161/431 (37%)
PKS_AT 533..833 CDD:214838 94/318 (30%)
hot_dog 895..1169 CDD:294345 63/384 (16%)
MDR 1471..>1522 CDD:302572 12/61 (20%)
KR_FAS_SDR_x 1593..1969 CDD:187582 104/411 (25%)
PP-binding 2018..2085 CDD:278949 20/87 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG3321
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D19161at2759
OrthoFinder 1 1.000 - - FOG0001625
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100178
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.720

Return to query results.
Submit another query.