DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ank3 and pyx

DIOPT Version :9

Sequence 1:	XP_036011414.1	Gene:	Ank3 / 11735	MGIID:	88026	Length:	4691	Species:	Mus musculus
Sequence 2:	NP_612015.1	Gene:	pyx / 38037	FlyBaseID:	FBgn0035113	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	345	Identity:	100/345 - (28%)
Similarity:	154/345 - (44%)	Gaps:	49/345 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse   427 LLKHGASIQAVTES-GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGE-TALHMAARSGQAEV 489
            ||||..:...|.:| |.||:|.|....:..|...|:..||.||..:.|.| |:||.||.|...|.
  Fly   118 LLKHYNADPNVADSRGRTPLHFACCRANAPIAKVLLDFGADPNRWDARKEVTSLHCAASSKSVEC 182

Mouse   490 VRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLAAREGHED 554
            :..|::..|.:.. ..:.::.||.:..:...|.|:.||:.||.||.......||||.|:..|...
  Fly   183 ILLLLRRKASINI-GIEKRSALHYAIDVNAVDCVEILLKYGADPNTPQVYTETPLHTASAAGFAK 246

Mouse   555 VAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVASLLLQKSASPDAAGKSGLTPLHVAAHYDNQ 619
            ....||.|.|.             |.:::|:                 ||  :|.||:||..|..
  Fly   247 CVQLLLSHNAD-------------VRSQFGE-----------------GK--VTALHLAAENDYV 279

Mouse   620 KVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATSLLEYGADANAVTRQGIASVHLA--AQE 682
            :.|.|||:..|.......:..||||:|.....:.....|:.|||:.|||.|.|..::|.|  .|.
  Fly   280 ECARLLLEHRAEVDCRNASHQTPLHLACLSQSIGTVDLLISYGANVNAVYRDGRTALHAAIVKQS 344

Mouse   683 GHVDMVSLLLSRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCH 747
            ..:|..:.||...|:||.::..|.||||:||..:..:.....:..||.:.|:|.
  Fly   345 RSLDCCNALLKAGADVNKADNYGYTPLHIAALNEFSSCVYTFIEHGADITARTD----------- 398

Mouse   748 YGNIKIVNFLLQHSAKVNAK 767
             |.:..::|:::.:.::..|
  Fly   399 -GRVSALSFIVRRTPEIIPK 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank3	XP_036011414.1	Ank_2	59..>304	CDD:423045
		ANK repeat	73..104	CDD:293786
		ANK repeat	106..137	CDD:293786
		ANK repeat	139..164	CDD:293786
		Ank_2	195..>437	CDD:423045	4/9 (44%)
		ANK repeat	205..240	CDD:293786
		ANK repeat	242..273	CDD:293786
		ANK repeat	275..306	CDD:293786
		ANK repeat	308..333	CDD:293786
		ANK repeat	341..372	CDD:293786
		PHA03095	377..>665	CDD:222980	72/239 (30%)
		ANK repeat	377..405	CDD:293786
		ANK repeat	407..438	CDD:293786	4/10 (40%)
		ANK repeat	440..471	CDD:293786	12/31 (39%)
		ANK repeat	473..504	CDD:293786	11/31 (35%)
		ANK repeat	506..537	CDD:293786	10/30 (33%)
		ANK repeat	539..568	CDD:293786	10/28 (36%)
		Ank_2	559..>796	CDD:423045	56/211 (27%)
		ANK repeat	572..601	CDD:293786	2/28 (7%)
		ANK repeat	605..634	CDD:293786	11/28 (39%)
		ANK repeat	638..669	CDD:293786	11/30 (37%)
		ANK repeat	671..702	CDD:293786	10/32 (31%)
		ANK repeat	704..735	CDD:293786	10/30 (33%)
		ANK repeat	737..768	CDD:293786	3/31 (10%)
		ANK repeat	770..798	CDD:293786
		Ank_4	771..823	CDD:372654
		ZU5	1018..1155	CDD:128514
		UPA_2	1377..1506	CDD:375346
		Herpes_BLLF1	<1542..1949	CDD:282904
		DUF2890	3296..>3412	CDD:314108
		Death_ank3	4113..4196	CDD:176781
pyx	NP_612015.1	Ank_4	99..153	CDD:290365	12/34 (35%)
		ANK repeat	102..130	CDD:293786	5/11 (45%)
		ANK	127..252	CDD:238125	40/125 (32%)
		ANK repeat	132..163	CDD:293786	11/30 (37%)
		Ank_2	137..226	CDD:289560	27/89 (30%)
		ANK repeat	166..196	CDD:293786	10/30 (33%)
		ANK	198..319	CDD:238125	40/152 (26%)
		ANK repeat	200..229	CDD:293786	10/28 (36%)
		Ank_2	203..296	CDD:289560	35/124 (28%)
		ANK repeat	231..262	CDD:293786	11/43 (26%)
		ANK	268..387	CDD:238125	41/118 (35%)
		ANK repeat	268..296	CDD:293786	11/27 (41%)
		Ank_2	270..364	CDD:289560	33/93 (35%)
		ANK repeat	298..329	CDD:293786	11/30 (37%)
		ANK repeat	331..364	CDD:293786	10/32 (31%)
		Ank_5	353..404	CDD:290568	17/62 (27%)
		ANK repeat	366..396	CDD:293786	9/29 (31%)
		Ion_trans	556..734	CDD:278921
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2336
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940