DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rheb and Diras2

DIOPT Version :9

Sequence 1:	NP_730950.2	Gene:	Rheb / 117332	FlyBaseID:	FBgn0041191	Length:	182	Species:	Drosophila melanogaster
Sequence 2:	NP_001019645.1	Gene:	Diras2 / 68203	MGIID:	1915453	Length:	199	Species:	Mus musculus

Alignment Length:	201	Identity:	71/201 - (35%)
Similarity:	115/201 - (57%)	Gaps:	23/201 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MP--TKERHIAMMGYRSVGKSSLCIQFVEGQFVDSYDPTIENTFTKIERVKSQDYIVKLIDTAGQ 63
            ||  :.:..:|:.|...||||||.::||:|.|.:||.||:|:|:.::.........:::.||.|.
Mouse     1 MPEQSNDYRVAVFGAGGVGKSSLVLRFVKGTFRESYIPTVEDTYRQVISCDKSICTLQITDTTGS 65

  Fly    64 DEYSIFPVQYSMDY---HGYVLVYSITSQKSFEVVKIIYEKLLDVMGK-KYVPVVLVGNKIDLHQ 124
            .:   ||....:..   |.::|||||||::|.|.:|.|||::.::.|. :.:|::|||||.|...
Mouse    66 HQ---FPAMQRLSISKGHAFILVYSITSRQSLEELKPIYEQICEIKGDVESIPIMLVGNKCDESP 127

  Fly   125 ERTVSTEEGKKLAESWRAAFLETSAKQNESVGDIFHQLLIL---------IENENGNPQE----- 175
            .|.|.:.|.:.||.:|:.||:|||||.|.:|.::|.:||.|         |:.:....|:
Mouse   128 NREVQSSEAEALARTWKCAFMETSAKLNHNVKELFQELLNLEKRRTVSLQIDGKKSKQQKRKEKL 192

  Fly   176 KSGCLV 181
            |..|:|
Mouse   193 KGKCVV 198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rheb	NP_730950.2	RheB	5..182	CDD:206709	69/195 (35%)
Diras2	NP_001019645.1	ARHI_like	7..170	CDD:206711	64/165 (39%)
Diras2	NP_001019645.1	Effector region. /evidence=ECO:0000255	36..44		4/7 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810