Protein Alignment Rheb and NRAS

DIOPT Version :10

• Sequence 1: NP_730950.2
• Gene: Rheb / 117332
• FlyBaseID: FBgn0041191
• Length: 182
• Species: Drosophila melanogaster
• Sequence 2: NP_002515.1
• Gene: NRAS / 4893
• HGNCID: 7989
• Length: 189
• Species: Homo sapiens
• Alignment Length: 181
• Identity: 67/181 - (37%)
• Similarity: 106/181 - (58%)
• Gaps: 6/181 - (3%)

  Fly     5 ERHIAMMGYRSVGKSSLCIQFVEGQFVDSYDPTIENTFTKIERVKSQDYIVKLIDTAGQDEYSIF 69
            |..:.::|...||||:|.||.::..|||.||||||:::.|...:..:..::.::|||||:|||..
Human     3 EYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAM 67

  Fly    70 PVQYSMDYHGYVLVYSITSQKSFEVVKIIYEKLLDVMGKKYVPVVLVGNKIDLHQERTVSTEEGK 134
            ..||.....|::.|::|.:.|||..:.:..|::..|.....||:||||||.|| ..|||.|::..
Human    68 RDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDL-PTRTVDTKQAH 131

  Fly   135 KLAESWRAAFLETSAKQNESVGDIFHQLL-----ILIENENGNPQEKSGCL 180
            :||:|:...|:|||||..:.|.|.|:.|:     ..::..|.:.....||:
Human   132 ELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCM 182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rheb	NP_730950.2	RheB	5..182	CDD:206709	67/181 (37%)
NRAS	NP_002515.1	H_N_K_Ras_like	3..164	CDD:133338	64/161 (40%)
		Effector region	32..40		6/7 (86%)
		Hypervariable region	166..185		3/17 (18%)