Protein Alignment Rheb and ERAS

DIOPT Version :10

• Sequence 1: NP_730950.2
• Gene: Rheb / 117332
• FlyBaseID: FBgn0041191
• Length: 182
• Species: Drosophila melanogaster
• Sequence 2: NP_853510.1
• Gene: ERAS / 3266
• HGNCID: 5174
• Length: 233
• Species: Homo sapiens
• Alignment Length: 197
• Identity: 59/197 - (29%)
• Similarity: 90/197 - (45%)
• Gaps: 23/197 - (11%)

  Fly     5 ERHIAMMGYRSVGKSSLCIQFVEGQFVDSYDPTIENTFTKIERVKSQDYIVKLIDTAGQDEYSIF 69
            |....::|...||||:|.||.....||:.:||||::::.|...:.|.|.|:.::|||||..:...
Human    41 EYKAVVVGASGVGKSALTIQLNHQCFVEDHDPTIQDSYWKELTLDSGDCILNVLDTAGQAIHRAL 105

  Fly    70 PVQYSMDYHGYVLVYSITSQKSFEVVKIIYEKLLDVMGKKYV-PVVLVGNKIDLHQERTVSTEEG 133
            ..|......|.:.|:::....|.    |..:::....|.... |:||||||.||......:....
Human   106 RDQCLAVCDGVLGVFALDDPSSL----IQLQQIWATWGPHPAQPLVLVGNKCDLVTTAGDAHAAA 166

  Fly   134 KKLAESWRAAFLETSAKQNESVGDIF----HQLLILIENENGNPQEKS--------------GCL 180
            ..||.||.|.|:|||||..:.|.:.|    |::..:.|.....|..:|              ||.
Human   167 AALAHSWGAHFVETSAKTRQGVEEAFSLLVHEIQRVQEAMAKEPMARSCREKTRHQKATCHCGCS 231

  Fly   181 VS 182
            |:
Human   232 VA 233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rheb	NP_730950.2	RheB	5..182	CDD:206709	58/195 (30%)
ERAS	NP_853510.1	RalA_RalB	42..201	CDD:206710	52/162 (32%)
		Effector region	70..78		4/7 (57%)