DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rheb and rheb-1

DIOPT Version :9

Sequence 1:	NP_730950.2	Gene:	Rheb / 117332	FlyBaseID:	FBgn0041191	Length:	182	Species:	Drosophila melanogaster
Sequence 2:	NP_499079.1	Gene:	rheb-1 / 176327	WormBaseID:	WBGene00010038	Length:	207	Species:	Caenorhabditis elegans

Alignment Length:	173	Identity:	74/173 - (42%)
Similarity:	113/173 - (65%)	Gaps:	2/173 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RHIAMMGYRSVGKSSLCIQFVEGQFVDSYDPTIENTFTKIERVKSQDYIVKLIDTAGQDEYSIFP 70
            |.:|:|||..||||:|.::|.:..|.:.|:.|||:..:|......:||.:::.|||||.||::||
Worm    14 RKVAVMGYPHVGKSALVLRFTQNIFPERYESTIEDQHSKHIAAFHRDYHLRVTDTAGQQEYTVFP 78

  Fly    71 VQYSMDYHGYVLVYSITSQKSFEVVKIIYEKLLDVMGKKYVPVVLVGNKIDLHQERTVSTEEGKK 135
            ...|:|.:|::|||:|..:||||:...||||::...|...:|:|:||||.||..:|.|..|||::
Worm    79 RSCSLDINGFILVYAIDDRKSFEMCSNIYEKIVRTYGDTSIPIVIVGNKTDLSTQRVVRAEEGEE 143

  Fly   136 LAESWRAAFLETSAKQNESVGDIFHQLLILIENENGN--PQEK 176
            ||..|.|.|:|.:|:::..|.::|..||..||...||  |.|:
Worm   144 LARQWDAKFVEITARESNRVHEVFELLLREIEISRGNLSPTER 186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rheb	NP_730950.2	RheB	5..182	CDD:206709	74/173 (43%)
rheb-1	NP_499079.1	RheB	13..207	CDD:206709	74/173 (43%)
rheb-1	NP_499079.1	small_GTPase	13..177	CDD:197466	70/162 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	142	1.000	Domainoid score	I2913
eggNOG	1	0.900	-	-		E2759_KOG0395
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	148	1.000	Inparanoid score	I2991
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320427at2759
OrthoFinder	1	1.000	-	-		FOG0002658
OrthoInspector	1	1.000	-	-		oto17970
orthoMCL	1	0.900	-	-		OOG6_104157
Panther	1	1.100	-	-	LDO	PTHR24070
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1095
SonicParanoid	1	1.000	-	-		X2033
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.860