DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rheb and Hras

DIOPT Version :9

Sequence 1:	NP_730950.2	Gene:	Rheb / 117332	FlyBaseID:	FBgn0041191	Length:	182	Species:	Drosophila melanogaster
Sequence 2:	NP_001123915.1	Gene:	Hras / 15461	MGIID:	96224	Length:	189	Species:	Mus musculus

Alignment Length:	188	Identity:	70/188 - (37%)
Similarity:	108/188 - (57%)	Gaps:	11/188 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ERHIAMMGYRSVGKSSLCIQFVEGQFVDSYDPTIENTFTKIERVKSQDYIVKLIDTAGQDEYSIF 69
            |..:.::|...||||:|.||.::..|||.||||||:::.|...:..:..::.::|||||:|||..
Mouse     3 EYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAM 67

  Fly    70 PVQYSMDYHGYVLVYSITSQKSFEVVKIIYEKLLDVMGKKYVPVVLVGNKIDLHQERTVSTEEGK 134
            ..||.....|::.|::|.:.||||.:....|::..|.....||:||||||.|| ..|||.:.:.:
Mouse    68 RDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL-AARTVESRQAQ 131

  Fly   135 KLAESWRAAFLETSAKQNESVGDIFHQLLILIEN---ENGNPQEKSG-------CLVS 182
            .||.|:...::|||||..:.|.|.|:.|:..|..   ...||.::||       |::|
Mouse   132 DLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS 189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rheb	NP_730950.2	RheB	5..182	CDD:206709	69/186 (37%)
Hras	NP_001123915.1	H_N_K_Ras_like	3..164	CDD:133338	63/161 (39%)
		Effector region	32..40		6/7 (86%)
		Hypervariable region	166..185		4/18 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810