DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment clt and LOC688542

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_038954018.1	Gene:	LOC688542 / 688542	RGDID:	1587637	Length:	559	Species:	Rattus norvegicus

Alignment Length:	590	Identity:	167/590 - (28%)
Similarity:	268/590 - (45%)	Gaps:	118/590 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CGRLIFTRFCSSMKVKVPVK-------QGVLVGRQKKLVNGLEYNSFLGVPYAEPPVGELRFRSP 63
            ||.|:............|::       :|.||..:.   ..::.::|||:|:|:||||.|||..|
  Rat    15 CGLLLLVLHVRGQDSASPIRNTHTGQVRGSLVHVKD---TDIDVHTFLGIPFAKPPVGPLRFAPP 76

  Fly    64 RPLERFQ------KQELDCSKEGNVSYQRDPFTLE-----VAGSEDCLFLNVYAPKVKSTRTPLP 117
            ...|.:.      .....|.:..|:....|...::     ::.|||||:||:|||......:.||
  Rat    77 EAPEPWSGVRDATSHPAMCLQNDNMMGSEDMKIMKLILPPISMSEDCLYLNIYAPTHAHEGSNLP 141

  Fly   118 VMVWIHGGGFFFGNGNSDFHFPAKLM--EQEVIVVTLNYRLGALGFLSLPEEGIHGNMGLKDQRL 180
            ||||||||....|..:.   :...::  .::|:|||:.||||.|||.|..:|...||.|..||..
  Rat   142 VMVWIHGGALTVGMASM---YDGSMLAATEDVVVVTIQYRLGVLGFFSTGDEHARGNWGYLDQVA 203

  Fly   181 ALEWVQENIASFNGDPNNVTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEWVFQNEAP 245
            ||.|||:|||.|.|:||.||:|||||||:||..|..:..::.|||.|||:||...:..:....:.
  Rat   204 ALRWVQQNIAHFGGNPNRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVVVLPDLISRSSE 268

  Fly   246 AKTRRLAELLGGGDFGGDSKALLTFLQSEKATPTAILANTLKVLSPDERRRHLPFAFKPVVEDSS 310
            ...|.:|.|  .|....||:.|:..|:.:.......:....|::              |.|.|.
  Rat   269 MVYRIVANL--SGCAAVDSETLMQCLRGKSEAEILDINKVFKII--------------PAVVDG- 316

  Fly   311 SPDRFLEQDIMELM-----HKKDCLGSMPVIMGYNSAEG---LAIVVKAKQKLEAYEDDLARLVP 367
               .||.:...||:     |:      :|.|:|.|:.|.   |.::..:.||:|.........|.
  Rat   317 ---EFLPKHPQELLASANFHR------VPSIIGINNDEYGWILPMIFDSAQKIEEITRKTLPTVL 372

  Fly   368 RN----LVLDPQAPEAQEAASDIRAFFFNGQALSKENMDNLVD----------LFSDYHFSMDLQ 418
            ::    ::|.|:.                |..|.:|.|.:..|          :..|:.|.:.
  Rat   373 KSTALKMMLPPEC----------------GDLLMEEYMGDTEDPKTLQAQFREMMGDFMFVIP-- 419

  Fly   419 RAVEIHASCQTQSPLYFYRLDYVGGRNLYKKIFQNEDLRGVAHADDICYLF-QMAGD----ETEM 478
             |:::....::.:|:|||...:   |:.:.|..:...:: ..|.|::..:| .:.||    .||
  Rat   420 -ALQVAHFQRSHAPVYFYEFQH---RSSFFKDVKPPHVK-ADHGDEVFLVFGYLVGDIKFPHTE- 478

  Fly   479 NRDDLMVTERLCEMWANFARDGKPS----PIWKPVKKPHNGEPIQLDCL-LIDRELKMCSNPDGE 538
              ::.:::.::.:.||||||.|.|:    |.| || ..|:.:.:|||.. .:.|.||      ..
  Rat   479 --EEELLSRKIMKYWANFARHGNPNSEGLPHW-PV-MDHDDQYLQLDIQPSVGRALK------AR 533

  Fly   539 RMDFW 543
            |:.||
  Rat   534 RLKFW 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	162/572 (28%)
LOC688542	XP_038954018.1	COesterase	30..538	CDD:395084	162/573 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910