DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clt and nlgn3b

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_005165239.1	Gene:	nlgn3b / 567415	ZFINID:	ZDB-GENE-060526-197	Length:	846	Species:	Danio rerio

Alignment Length:	548	Identity:	162/548 - (29%)
Similarity:	236/548 - (43%)	Gaps:	140/548 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 NSFLGVPYAEPPVGELRFRSP---------RPLERF--------QKQELDCSKEGNVSYQRDPF- 89
            :.:||||||.|||||.||..|         |...||        :....|.......:|..|..
Zfish    71 DQYLGVPYAAPPVGEKRFMPPDAPSAWSGVRNATRFPPVCPQTVRNAVPDIMMPVWATYNMDTVA 135

  Fly    90 TLEVAGSEDCLFLNVYAPKVKSTR----------------------TPLPVMVWIHGGGFFFGNG 132
            |.....|||||::|:|.|....|:                      .|.|||::||||.:..|.|
Zfish   136 TYLQEQSEDCLYMNIYVPTQSGTKRTGDMSADTERTEDDGLRDSRDDPRPVMLFIHGGSYMEGTG 200

  Fly   133 NSDFHFPAKLME-------QEVIVVTLNYRLGALGFLSLPEEGIHGNMGLKDQRLALEWVQENIA 190
            |        :|:       ..|||:|||||:|.|||||..::...||.||.||..||.|:.:||.
Zfish   201 N--------IMDGSVLASYGNVIVITLNYRVGILGFLSTGDQAAKGNYGLLDQIQALRWINKNIG 257

  Fly   191 SFNGDPNNVTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEWVFQNEAPAK-TRRLAEL 254
            .|.|||..||:||...|.|.|.|.|.:.|::.|||:||:|||:|...|.. |..|.| ||.|||.
Zfish   258 YFGGDPGRVTVFGSGIGASCVSLLTLSHHSEGLFHRAIIQSGSALSSWSV-NYQPVKYTRLLAER 321

  Fly   255 LGGGDFGGDSKALLTFLQSEKATPTAILANTLKVLSPDERRRHLPFAFKPVVEDSSSPD------ 313
            :|....  |::.|:..:|  |.:...::...::     ..|.|:  ||.||::....||
Zfish   322 VGCNVL--DTQDLVLCMQ--KRSYRELVEQEIQ-----PARFHV--AFGPVIDGDLIPDDPEVLM 375

  Fly   314 ---RFLEQDIMELMHKKDCLGSMPVIMGYNSAEGLAIVVKAKQKLEA-------------YEDDL 362
               .||..|||               :|.|..||...|....:..|.             :.|.|
Zfish   376 EQGEFLNYDIM---------------LGVNQGEGFRFVEGVVEPEEGGVSGSDFDFTVSDFVDSL 425

  Fly   363 ARLVPRNLVLDPQAPEAQEAASDIRAFFFNGQALSKENMD----NLVDLFSDYHFSMDLQRAVEI 423
            ...           ||.::...:...|.:...| .::|.:    .||.:|:|:.:........::
Zfish   426 YGY-----------PEGKDTLRETIKFMYTDWA-DRDNPETRRKTLVAMFTDHQWVEPAVVTADL 478

  Fly   424 HASCQTQSPLYFYRLDYVGGRNLYKKIFQNEDLRGVAHADDICYLF--QMAGDETEM-----NRD 481
            ||  :..||.:||.. |...::..|..:.:.     ||.|::.|:|  .:.| .||:     :|:
Zfish   479 HA--RYGSPTFFYAF-YHHCQSPMKPPWADS-----AHGDELPYVFGVPLIG-PTELFPCNFSRN 534

  Fly   482 DLMVTERLCEMWANFARDGKPSPIWKPV 509
            |:|::..:...|.|||:.|.|:   |||
Zfish   535 DIMLSAVVMTYWTNFAKTGDPN---KPV 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	162/548 (30%)
nlgn3b	XP_005165239.1	COesterase	40..609	CDD:278561	162/548 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810