DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clt and si:dkey-30c15.17

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_003200472.2	Gene:	si:dkey-30c15.17 / 561375	ZFINID:	ZDB-GENE-060503-450	Length:	657	Species:	Danio rerio

Alignment Length:	582	Identity:	170/582 - (29%)
Similarity:	240/582 - (41%)	Gaps:	138/582 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LVGRQKKLVNGL---EYNSFLGVPYAEPPVGELRFRSPRPLERFQKQELDCSKEGNVSYQRDPFT 90
            |:||    |.||   :.:.|.|:|||:||||:.|:..|.|:..:....       |.::.|....
Zfish   141 LLGR----VRGLTLEKAHVFYGIPYADPPVGDKRWAPPSPVSPWLYTY-------NATFPRPACM 194

  Fly    91 LEVAG----------SEDCLFLNVYA--------PKVKSTRTPLPVMVWIHGGGFFFGNGNSDFH 137
            ...||          |||||:|||:.        |||    |.||||||||||.|..|:.:...:
Zfish   195 QMCAGEFSRLCPPEVSEDCLYLNVFVPVSVNLSLPKV----TALPVMVWIHGGDFIAGSASKPLY 255

  Fly   138 FPAKLME-QEVIVVTLNYRLGALGFLSL---PEEGIHGNMGLKDQRLALEWVQENIASFNGDPNN 198
            ....:.. ...:||.:.|||||.|||..   ||....||.|:.||:.||.|||||||:|.||||.
Zfish   256 DGRYISNYSNTVVVNMEYRLGAFGFLVTGKDPESSAVGNYGILDQQAALHWVQENIAAFGGDPNK 320

  Fly   199 VTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEWVFQNEAPAKTRRLAELLGGGDFGGD 263
            |||||||||..||.||...:.::.||..|.:||...::        |.|||..|..| |.||
Zfish   321 VTLFGESAGAQSVSLHLMMQSSETLFRHAAIQSLPFSL--------PLKTRWDAMKL-GWDF--- 373

  Fly   264 SKALLT-----------FLQSEKATPTAILANTLKVLSPDERRRHLPFAFKPVVEDSSSP---DR 314
              |.||           .|.||......|.:.: |:::        ||.|..|.| :..|   .:
Zfish   374 --AKLTNCSVFDLPCMRSLSSEDVLNAQIKSGS-KIIN--------PFRFLEVFE-TWGPFIDGQ 426

  Fly   315 FLEQDIMELMHKKDCLGSMPVIMGYNSAEGLAIVV----KAKQKLEAYEDDLARLVPRNLVLDPQ 375
            .|::..:....|.......|||:|..|.||:..|.    |:...||.             ||...
Zfish   427 LLKEQPITAFQKGHWQSYKPVILGTTSEEGVMFVYRNFNKSVSMLEC-------------VLYTA 478

  Fly   376 APEAQEAASDIRAF--FFNGQALSKENMDNLVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFYRL 438
            |...|.|...:..:  |:..|    :....|..:.:||.||...:::.  .:..:....::.|..
Zfish   479 AIFKQHALKILHKYIPFYRNQ----DRRVMLSQMVTDYVFSCPARQSA--RSGVKVGGAVWMYVF 537

  Fly   439 DYV-GGRNLYKKI--FQNEDLRGVAHADDICYLFQMA-GDETEMNRDDLMVTERLCEMWANFARD 499
            |:. ...|::.::  ..|..    .|..::.:||..| .........:.::..|:...|..||..
Zfish   538 DHAPSDPNIWAELTFCYNHS----CHGAELPFLFDSAPSTNFTFTPQERLLANRMACYWGMFAHT 598

  Fly   500 GKPS--------------PIWKPVKKPHNGEPIQLDCLLIDRELKMCSNPD-GER---MDFW 543
            |.|:              |:| |......|..|        ..|.:.|:|. |.|   .|||
Zfish   599 GDPNSRDEQTHFCREQRLPVW-PRYTDIGGWTI--------LNLTLQSHPQHGSRDHFCDFW 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	168/580 (29%)
si:dkey-30c15.17	XP_003200472.2	COesterase	134..651	CDD:306613	168/580 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910