Protein Alignment clt and Nlg4

DIOPT Version :10

• Sequence 1: NP_536784.1
• Gene: clt / 117300
• FlyBaseID: FBgn0000326
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Alignment Length: 756
• Identity: 171/756 - (22%)
• Similarity: 252/756 - (33%)
• Gaps: 300/756 - (39%)

  Fly     8 RLIFTRFCSSMKVKVPVKQGVLVGRQKKLVNGLE-------YNSFLGVPYAEPPVGELRF---RS 62
            |::.||:                ||...|:..|:       ...|||||||.||..:.||   |:
  Fly    42 RIVQTRY----------------GRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRA 90

  Fly    63 PRP-----------------LERFQKQ--ELDCSKEGNVSYQRD--PFTLEVAGSEDCLFLNVYA 106
            |.|                 |...|.:  .|:...:|.:.|.:.  || || ..|||||:|||::
  Fly    91 PAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRLLPF-LE-NQSEDCLYLNVFS 153

  Fly   107 P-KVKSTRTPLPVMVWIHGGGFFFGNGNSDFHFPAKLMEQ--EVIVVTLNYRLGALGFLSL-PEE 167
            | ...:....|||:|:|||..|.:.:||.   :...::..  ||:|||||||||.||||:. |..
  Fly   154 PVNAGANEKKLPVIVFIHGESFEWSSGNP---YDGSVLASYGEVVVVTLNYRLGILGFLNANPNP 215

  Fly   168 GIH---GNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAGGSSV-HLHTFARHAKRLFHKAI 228
            ..|   .|.||.||..||.|:|:||..|.||||:|||.|...|.:.: :|.|.....:.|||:||
  Fly   216 HAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAI 280

  Fly   229 MQSGTANMEWVFQNEAPAKTRRLAELLGGGDFGGDSKALLTFLQSEKATPTAI-LANTLKVLSPD 292
            :.||:|...|                           ||:     |.....|| ||..:....||
  Fly   281 LMSGSAYSSW---------------------------ALV-----EDPVLFAIKLAKEVNCTIPD 313

  Fly   293 ERRRHLPFAFKPVVEDSSSPDRFLEQDIMELMHKK--DCLGSMPVIMGYNSAEGLAIV-VKAKQK 354
            :..||                           |::  |||..:|:       |.|.:. ::|...
  Fly   314 DINRH---------------------------HEQIVDCLRDVPL-------EDLYLADIQAPNF 344

  Fly   355 LEAYEDDLARLVPR----NLVLDP-QAPEAQEAASD----------------------------I 386
            |.::...:..:|.|    ||.:|. .|..::.:::|                            .
  Fly   345 LTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSF 409

  Fly   387 RAFFFNGQALSKENM-------------------------------------------------- 401
            ...:|.|......||
  Fly   410 GGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQNGFEGERRDKIIRTYVRNAYNYHLN 474

  Fly   402 ------------------------DNLVDLFSDYHFSMDLQRAVEIHA----------------- 425
                                    |..|...||..|...:.||.:|.|
  Fly   475 EIFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPG 539

  Fly   426 ----------SCQTQSPLYFYRLDYVGGRNLYKKIFQNED-----LRGVAHADDICYLF------ 469
                      |.|.....|||..||           |.:|     ..|..|.:|:.|:|
  Fly   540 ANAAASTSAGSTQPSGRCYFYVFDY-----------QTKDGDYPQRMGTVHGEDLPYIFGAPLVD 593

  Fly   470 QMAGDETEMNRDDLMVTERLCEMWANFARDGKPSPIWK-----PVKKPHNG---------EPIQL 520
            ..:.......:.:..::|.:...|.||||.|.|:...:     ||.|..|.         :|:..
  Fly   594 GFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQ 658

  Fly   521 DCLLIDRELKMCSNPDGERMDFWRSMYRRYRSENFEAVRAK 561
            ..|.|..:.::.::....::..|..:.........|.|.|:
  Fly   659 KYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAGMEDVIAR 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	alpha/beta hydrolases	22..543	CDD:473884	164/722 (23%)
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	166/735 (23%)