DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clt and alpha-Est2

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	209/561 - (37%)
Similarity:	300/561 - (53%)	Gaps:	48/561 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RFCSSMKVKVPVKQGVLVGRQKKLVNGLE-YNSFLGVPYAEPPVGELRFRSPRPLERFQKQELDC 76
            |..:...|.:..|.|.:.|.|:|.|...| |.:|.|:|||:||||:||||:|:|.|.:| ..|:|
  Fly    26 RLSTGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQ-GVLNC 89

  Fly    77 SKEGNVSYQRDPFTLEVAGSEDCLFLNVYAPKVKSTRTPLPVMVWIHGGGFFFGNGNSDFHFPAK 141
            :...:...||:.....|.||||||.||||...:||.: ||||:|||:||||..|..:.|.:.|..
  Fly    90 TTNRSKPMQRNMLLGIVEGSEDCLHLNVYVKALKSEK-PLPVIVWIYGGGFQKGEASRDIYSPDY 153

  Fly   142 LMEQEVIVVTLNYRLGALGFLSL--PEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGE 204
            .|::.|:.|.:||||.|||||||  |:..:.||.|||||.:||.|:.:|||.|||||||:||.||
  Fly   154 FMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFNGDPNNITLMGE 218

  Fly   205 SAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEWVFQNEAPAK--TRRLAELLGGGDFGGDSK-- 265
            |||.:|||:.......:.||||||||||.|..|||   |:|..  ..|||:.||   :.||.|
  Fly   219 SAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWV---ESPDNNWAFRLAQNLG---YKGDEKDA 277

  Fly   266 ALLTFLQSEKATPTAILANTLKVLSPDERRRHLPFAFKPVVEDSSSPDRFLEQDIMELMHKKDCL 330
            .:|:||  .|.....|.|....|::.||.|..|.|||.||:|...:     :..::...| ||.|
  Fly   278 DVLSFL--SKVCARQIAAIDQDVINLDEVRSFLLFAFGPVIEPYET-----DHCVVPKRH-KDLL 334

  Fly   331 -----GSMPVIMGYNSAEGL---AIVVKAKQKLEAYEDDLARLVPRNLVLDPQAPEAQE-AASDI 386
                 ..:|||:|.||.|||   .:|.|....|:.:.:    ::||. |.:..:.|.|: ....:
  Fly   335 SEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWALKNFHN----ILPRE-VRETSSLEGQDLLVRRL 394

  Fly   387 RAFFFNGQALSKENMDNLVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFYRLDYVGGR-NLYKKI 450
            :..:||.:......|...:::||......|..|.:....|...::|.|.||.|:.... |.::::
  Fly   395 KQLYFNNEMQESMEMFEALNIFSHRQIWHDTHRFILARQSYAPKTPTYLYRFDFDSPHFNQFRRL 459

  Fly   451 FQNEDLRGVAHADDICYLF-QMAGDETEMNRDDLMVTERLCEMWANFARDGKP------SPIWKP 508
            ...:.:|||||||::.||| .:...:.:.:..:....||:..||.:||..|.|      |..|:.
  Fly   460 VCGDRIRGVAHADELSYLFYNIIASKLDKSSMEYKTIERMVGMWTSFASSGNPNCPELGSAKWEA 524

  Fly   509 VKKPHNGEPIQLDCLLIDRELKMCSNPDGERMDFWRSMYRR 549
            |:...|...   .|..|..:|:|...|:.:.:..|.:.|.|
  Fly   525 VQLKENAVE---KCFNISHDLEMRDLPESDCLAVWDTFYPR 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	204/544 (38%)
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	197/511 (39%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	58/104 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.870