DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clt and alpha-Est4

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	185/549 - (33%)
Similarity:	292/549 - (53%)	Gaps:	49/549 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PVKQ---GVLVGRQKKLVNGLEYNSFLGVPYAEPPVGELRFRSPRPLERFQKQELDCSKEGNVSY 84
            ||.|   |.:.|...|.:...::.:|.|:|||.||:|.|||:.|..|:.:.... ||||..:...
  Fly    10 PVVQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIR-DCSKPLSKCL 73

  Fly    85 QRDPFTLEVAGSEDCLFLNVYAPKVKSTR-TPLPVMVWIHGGGFFFGNGNSDFHFPAKLMEQEVI 148
            |....|.||.||||||:||:   .||:.. .|:||||:||||.|..|:.:.....|...|::.|:
  Fly    74 QVSTLTKEVEGSEDCLYLNI---SVKTLNGDPMPVMVYIHGGAFKGGDSSRRAWGPDYFMKENVV 135

  Fly   149 VVTLNYRLGALGFLSL--PEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAGGSSV 211
            .:::.:|||.||||||  |:..:.||.||||..|||.|::.|.|:|||||..:|:||.|:|..:|
  Fly   136 YISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTV 200

  Fly   212 HLHTFARHAKRLFHKAIMQSGTANMEWVFQNEAPAKTRRLAELLGGGDFGGDS--KALLTFLQSE 274
            .|...:..::.|||:||:.:| .:||   .|..|....|||:.||   :.||:  ..:|.||.
  Fly   201 QLLLASPQSEGLFHRAILLAG-FSME---LNRLPQMEYRLAKHLG---YEGDNVDSQVLEFLL-- 256

  Fly   275 KATPTAILANTLKVLSPDERRRHLPFAFKPVVEDSSSPDRFLEQDIMELMHKKDCLGSMPVIMGY 339
            ||.|..|:  :....:|.|:|:.....|||.:|..|:|:..|..:.::| .:......:|:|:|.
  Fly   257 KADPALIV--SADFFTPLEKRQGHNMPFKPSIESYSTPNAVLLAEPIDL-QRTTWSNRIPIILGA 318

  Fly   340 NSAEGLAIVVKAKQK---LEAYEDDLARLVP---RNLVLDPQAPEAQEAASDIRAFF-FNGQALS 397
            ||.||::|....|..   |:.::.:..|::|   ||. .|| ....|...:.|..|. .:|..|:
  Fly   319 NSGEGMSIFSFVKMNPSWLKEFQCNPERVLPWTLRNR-CDP-GQRRQLGQALIHHFCEAHGHELT 381

  Fly   398 KENMDNLVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFYRLDYVG-GRNLYKKIFQNEDLRGVAH 461
            .::.:.||:||: :.|...:.|.::...: ..|:|.|.||.|:.. ..|.|:..|..::.|||.|
  Fly   382 VDHTNGLVELFT-HGFVHAMDRLIQSRLT-YGQAPTYLYRFDFDSPDFNFYRIRFMGKEQRGVGH 444

  Fly   462 ADDICYLFQM-AGDETEMNRDDLMVTERLCEMWANFARDGKP-SPI------WKPVKKPHNGEPI 518
            .|::.|:|:: |..:.:.:|.:.....||..|:..||....| :|:      ||||.:  .|:.:
  Fly   445 VDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTKSLVDWKPVTR--FGKRM 507

  Fly   519 QLDCLLIDRELKMCSNPDGERMDFWRSMY 547
            .|:   |..|||....|:..::.|:..:|
  Fly   508 VLN---ISEELKFIPQPEMPKLKFFDRLY 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	183/543 (34%)
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	183/543 (34%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	52/114 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	1	0.950	-	0	Normalized mean entropy	S4412
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.820