DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clt and Est-Q

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	155/538 - (28%)
Similarity:	249/538 - (46%)	Gaps:	91/538 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 YNSFLGVPYAEPPVGELRFRSP----------RPLERFQKQELDCSKEGNVSYQRDPFTLEVAGS 96
            :..|.|:|:||||:.|||||.|          ..|...|:    |....|:..|     :..|..
  Fly    67 FMQFRGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQR----CPVITNLDSQ-----MSDAEL 122

  Fly    97 EDCLFLNVYAPKVKSTRTPLPVMVWIHGGGFFFGNGNSDFHFPAKLMEQEVIVVTLNYRLGALGF 161
            ||||.|:||...:.:::   |||.:|:||||:  ||:|:.|.|..|:|::|::|...||:||||:
  Fly   123 EDCLTLSVYTKNLSASQ---PVMFYIYGGGFY--NGSSEDHPPNYLLEKDVVLVVPQYRVGALGW 182

  Fly   162 LSLPEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAG-GSSVHLHTFARHAKRLFH 225
            ||...|.:.||..:.|..:||:|||.:|:||.|||..||:||:||| |.:..|....:....:|.
  Fly   183 LSTYTEELPGNAPIADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDNMFK 247

  Fly   226 KAIMQSGTANMEWVFQNEAPAKTRRLAELLG-GGDFGGDSKALLTFLQSEKATPTAILANTLKVL 289
            :||:|||:....|....:..|::||:...|| .|....|        |..|....|.:.:.||..
  Fly   248 RAIVQSGSIFASWAINKDPKAQSRRICIQLGCSGCEQHD--------QLVKCIQKAKVIDILKAT 304

  Fly   290 SPDERRRHLPFAFKPVVEDSSSPDRFLEQDIMELMHKKDCLGSMPVIMGYNSAEGLAIVVKAKQK 354
            :.:        :|.|:|.|...   .|.|...||:  |.....:|::.|:...:|..:
  Fly   305 ASE--------SFSPIVGDLHG---ILPQQPSELV--KSYRRQIPILTGFTQHDGSFV------- 349

  Fly   355 LEAYEDDLARLVPR--NLVLDPQAPEAQEAASD--------IRAFFFNGQALSKENMDNLVDLFS 409
            |.:|.|.||..|..  :|.:...:....:..:|        :....|..|||:..:....|..:.
  Fly   350 LASYYDALAAKVANVSSLSVRQFSQGINDLVNDTSGLTDNILNRLLFKPQALNSHDHSAAVSSYF 414

  Fly   410 DYHFSMDLQRAVEIHA----SCQTQSPLYFYRLDYVGGRNLYKKIFQNEDL---RGVAHADDICY 467
            |...::.::..|...|    :.|..:|:|.|..:|.|....:...|.|...   .||.|::|..|
  Fly   415 DLTTNIFMKSPVITLATKMYTQQRSTPVYVYSFEYEGTYTRFGYEFGNSHYPFNGGVHHSNDNIY 479

  Fly   468 LF---QMAGDETEMNRDDLMVTERLCEMWANFARDGKP---SPIWKPVKKPHNGEPIQLDCL--- 523
            ||   .:.|.:|:|       ::::.::|.:||.:|.|   ||: .....|:|  .:.|:..
  Fly   480 LFATHPLEGQDTQM-------SQKMVDVWTSFAIEGVPRNLSPL-SSASGPYN--KLNLEVTKGD 534

  Fly   524 -LIDRELKMCSNPDGERM 540
             |:|.......:||..|:
  Fly   535 DLLDTLTAAIDDPDNGRL 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	155/538 (29%)
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	152/528 (29%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	49/107 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.870