Protein Alignment clt and AADACL4

DIOPT Version :10

• Sequence 1: NP_536784.1
• Gene: clt / 117300
• FlyBaseID: FBgn0000326
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_001013652.1
• Gene: AADACL4 / 343066
• HGNCID: 32038
• Length: 407
• Species: Homo sapiens
• Alignment Length: 307
• Identity: 74/307 - (24%)
• Similarity: 123/307 - (40%)
• Gaps: 57/307 - (18%)

  Fly    81 NVSYQRDPFTLEVAGSEDCLF----LNVYAPKVKSTRTPLPVMVWIHGGGFFFGNGNSDFHFPAK 141
            :|..::|| .|.|.   |..|    :.::.||..|:| |...:::.|||...||:.:. :|....
Human    78 SVRIKKDP-ELVVT---DLRFGTIPVRLFQPKAASSR-PRRGIIFYHGGATVFGSLDC-YHGLCN 136

  Fly   142 LMEQEVIVVTLNYRLGALGFLSLPEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESA 206
            .:.:|...|.|     .:|:..||:.  |.....:|...|.....:.:.::..||:.|.:.|||.
Human   137 YLARETESVLL-----MIGYRKLPDH--HSPALFQDCMNASIHFLKALETYGVDPSRVVVCGESV 194

  Fly   207 GGSSVHLHTFA--------RHAKRLFHKAIMQSGTANMEWVFQNE-APAKTRRLAELLGGGDFGG 262
            ||::|...|.|        |...::....::|:....:....||: .|..:|:..
Human   195 GGAAVAAITQALVGRSDLPRIRAQVLIYPVVQAFCLQLPSFQQNQNVPLLSRKFM---------- 249

  Fly   263 DSKALLTFLQSEKATPTAILANTL----------KVLSPDERRRHLPFAFKPVVEDSSSPDRFLE 317
             ..:|..:|..:.:...|||..|.          |.||||    ::|..||.......||..|.|
Human   250 -VTSLCNYLAIDLSWRDAILNGTCVPPDVWRKYEKWLSPD----NIPKKFKNRGYQPWSPGPFNE 309

  Fly   318 QDIMELMHKKDCLGSMPVIMGYNSAEGLAIVVKAKQKLEAYEDDLAR 364
            ...:|..|..|...| |:|     |:...|....:..|.:.|:|:.|
Human   310 AAYLEAKHMLDVENS-PLI-----ADDEVIAQLPEAFLVSCENDILR 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	alpha/beta hydrolases	22..543	CDD:473884	74/307 (24%)
AADACL4	NP_001013652.1	alpha/beta hydrolases	115..378	CDD:473884	62/265 (23%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	119..121		1/1 (100%)