DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clt and CG6414

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	562	Identity:	183/562 - (32%)
Similarity:	282/562 - (50%)	Gaps:	71/562 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GVLVGRQKKLVNGLEYNSFLGVPYAEPPVGELRFRSPRPLERFQKQELDCSKEGNVSYQRDPFTL 91
            |.|:||.....||....:|:||||||||:.:||||.|.|...::.:.| ..|:..:..|||||..
  Fly    38 GWLIGRHLTTHNGRHMRAFMGVPYAEPPLDDLRFRPPVPKAPWEGERL-AIKDAPICLQRDPFRR 101

  Fly    92 E--VAGSEDCLFLNVYAPKVKSTRTPLPVMVWIHGGGFFFGNGNSDFHFPAKLMEQEVIVVTLNY 154
            :  :.||||||:||||.|:...|...||||||.||||:..|:|.|.|:.|..|::.::::|:.|:
  Fly   102 DMILEGSEDCLYLNVYTPERPRTNGSLPVMVWFHGGGWQCGSGISSFYGPDFLLDHDIVLVSANF 166

  Fly   155 RLGALGFLSLPEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAGGSSVHLHTFARH 219
            |||.|||||.......||.|||||...|.||:.|||||.||||:||:|||||||:||..|..:..
  Fly   167 RLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSEK 231

  Fly   220 AKRLFHKAIMQSGTANMEW---VFQNEAPAKTRRLAELLGGGDFGGDSKALLTFLQSEKATPTAI 281
            ::.|.|:.|.||||....|   ..:..|..:..:||:::|.|: .|:....|..|:.:.|.....
  Fly   232 SRGLLHRGIAQSGTYFNPWAQPAHKGVAAGRATKLAQIVGCGN-AGEWPEKLECLRKKPAEDIVA 295

  Fly   282 LANTLKVLSPDERRRHLPFAFKPVVED-------SSSPDRFLEQDIMELMHKKDCLGSMPVIMGY 339
            ....:.|...|..   :|  |.||||.       :.:|.:..:...::|          |:::|.
  Fly   296 SLYDMFVWDFDPM---IP--FPPVVEPEHDGAFLTVAPRQAAKPHGLQL----------PLMVGA 345

  Fly   340 NSAEGL---AIVVKAKQKLEAYEDDLARLVPRNLVLDPQAPEAQEAASD-IRAFFF-NGQALSKE 399
            .:.|||   |.::...|.|..::....:::|..|..|......::..:. |.:|:| :|....|.
  Fly   346 TAEEGLLKTAALLNLPQLLAEFKSQFEQVLPVVLNYDHHDDSVRQTITQRIESFYFKSGHDYDKA 410

  Fly   400 NMDNLVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFYRLDYVGGRNLYKKIFQ--NEDLRGVAHA 462
            |..||.||.||..|...:...:.:..|.:..:|.|.|..|:.|..: :.:||:  ..:..|..||
  Fly   411 NHQNLTDLISDGWFVAGIDEYLRLRMSQEDVAPTYVYLFDHKGAAS-FTEIFKGGRNEFYGACHA 474

  Fly   463 DDICYLFQMAGDETEMN----RDDLMVTERLCEMWANFARDGKPSPI--------WKPVKKPHNG 515
            :::.|||.: |.|..::    :.||.:.|.:..:|.:||:.|.|:|.        |.|.    :.
  Fly   475 EELQYLFPI-GRELFVSAVPTQKDLELRELMLHLWVSFAKTGNPNPTNVSFHLPNWSPA----SS 534

  Fly   516 EPIQL-----------DCLLIDRELKMCSNPDGERMDFWRSM 546
            .|::.           ....::.||..      .|:||||.:
  Fly   535 YPVEFARLGTKMEDSASIFRLENELMQ------HRVDFWRDL 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	180/557 (32%)
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	180/557 (32%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	69/137 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.960