DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clt and Ces1e

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_113753.2	Gene:	Ces1e / 29225	RGDID:	621508	Length:	561	Species:	Rattus norvegicus

Alignment Length:	542	Identity:	171/542 - (31%)
Similarity:	247/542 - (45%)	Gaps:	98/542 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SSMKVKVPVKQGVLVGRQKKLVNGLE-YNSFLGVPYAEPPVGELRFRSPRPLE--RFQK------ 71
            ||:.| |...||.::|:...|....: ...|||||:|:||:|.|||..|:|.|  .|.|
  Rat    21 SSLPV-VDTLQGKVLGKYVSLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYP 84

  Fly    72 -------------QELDCSKEGNVSYQRDPFTLEVAGSEDCLFLNVYAPKVKSTRTPLPVMVWIH 123
                         .:|..::|.|:|.|         .|||||:||:|.|...:.|..||||||||
  Rat    85 PMCSQDPVAGQIVNDLLTNREENISLQ---------FSEDCLYLNIYTPADLTKRDRLPVMVWIH 140

  Fly   124 GGGFFFGNGNSDFHFPAKLMEQEVIVVTLNYRLGALGFLSLPEEGIHGNMGLKDQRLALEWVQEN 188
            |||...| |.|.:...|....:.|:||.:.||||..||.|..:|...||.|..||..||.|||:|
  Rat   141 GGGLVLG-GASTYDGLALSTHENVVVVVIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALHWVQDN 204

  Fly   189 IASFNGDPNNVTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEWVFQNEAPAKTRRLAE 253
            |.:|.|||.:||:|||||||.||.:...:..||.||||||.:||.|....:.:.    .||.|||
  Rat   205 IDNFGGDPGSVTIFGESAGGESVSVLVLSPLAKNLFHKAISESGVALTAGLVKK----NTRPLAE 265

  Fly   254 LLG--GGDFGGDSKALLTFLQSEKATPTAILANTLKV------LSPDERRRHLPFAFKPVVEDSS 310
            .:.  .|.....|.|::..|:.:  |...:|..|||:      |..|.|:   .:.|.|.|.|..
  Rat   266 KIAVVSGCKSTTSAAMVHCLRQK--TEEELLETTLKLNLFSLDLHGDSRQ---SYPFVPTVLDGV 325

  Fly   311 SPDRFLEQDIMELMHKKDCLGSMPVIMGYNSAEGLAIVVKAKQKLEAYEDDLARLVPRNLVLDPQ 375
            ...:..|    |::.:|| ..::|.|:|.|           ||:.......:....|.::.|||.
  Rat   326 VLPKMPE----EILAEKD-FNTVPYIVGIN-----------KQEFGWILPTMMNYPPSDMKLDPM 374

  Fly   376 APEAQEAASDIR--AFFFN------GQALSK---------ENMDNLVDLFSDYHFSMDLQRAVEI 423
            .     |.|.::  :|..|      ..|:.|         .|.|.|::|..|..|.:........
  Rat   375 T-----ATSLLKKSSFLLNLPEEAIPVAVEKYLRHTDDPDRNKDQLLELIGDVIFGVPSVIVSRG 434

  Fly   424 HASCQTQSPLYFYRLDYVGGRNLYKKIFQNEDLRGVAHADDICYLFQMAGDETEMNRDDLMVTER 488
            |.....::  |.|...|   |..:....:...:.| .|.|:|..:|.........:::::.:::.
  Rat   435 HRDAGART--YMYEFQY---RPSFSSKMKPSTVVG-DHGDEIYSVFGAPILRGGTSKEEINLSKM 493

  Fly   489 LCEMWANFARDGKPS----PIW 506
            :.:.||||||:|.|:    |.|
  Rat   494 MMKFWANFARNGNPNGQGLPHW 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	168/536 (31%)
Ces1e	NP_113753.2	COesterase	24..545	CDD:278561	169/539 (31%)
		Aes	43..>239	CDD:223730	87/205 (42%)
		Prevents secretion from ER (Potential)	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010