DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clt and Ces2i

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_008758816.2	Gene:	Ces2i / 292152	RGDID:	1565045	Length:	558	Species:	Rattus norvegicus

Alignment Length:	580	Identity:	166/580 - (28%)
Similarity:	264/580 - (45%)	Gaps:	99/580 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CGRLIFTRFCSSMKVKVPVKQ---GVLVG---RQKKLVNGLEYNSFLGVPYAEPPVGELRFRSPR 64
            ||.|:..:.........|::.   |.:.|   ..|...:|:  ::|||:|:|:||||.|.|..|.
  Rat    15 CGLLLLLQHVHGQDSASPIRNTQTGQVRGSFVHVKDTKSGV--HTFLGIPFAKPPVGPLHFAPPE 77

  Fly    65 PLERFQK----------------QELDCSKEGNVSYQRDPFTLEVAGSEDCLFLNVYAPKVKSTR 113
            ..|.:..                .:.|..||..::....|.      |||||:||:|.|......
  Rat    78 DPEPWSGVRDGTSQPDMCLQTDIMKEDFIKEMKLTMHPTPM------SEDCLYLNIYTPAHAREG 136

  Fly   114 TPLPVMVWIHGGGFFFGNGNSDFHFPAKLMEQEVIVVTLNYRLGALGFLSLPEEGIHGNMGLKDQ 178
            :.|||||||||||...|:.:.:........| |:::|.:.||||.|||.|..:|...||.|..||
  Rat   137 SNLPVMVWIHGGGLVLGSASMNVASTLAATE-EIVIVAIQYRLGILGFFSTGDEHARGNWGYLDQ 200

  Fly   179 RLALEWVQENIASFNGDPNNVTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEWVFQNE 243
            ..||.|||:|||.|.|:...||:||.||||:||..|..:..:|.|||.||||||.|.:..:..:.
  Rat   201 VAALCWVQQNIAYFGGNHGKVTIFGVSAGGTSVSSHVVSPMSKGLFHGAIMQSGVALLPDLISDT 265

  Fly   244 APAKTRRLAELLGGGDFGGDSKALLTFLQSEKATPTAILANTLKVLSPDERRRHLPFAFKPVVED 308
            :....:.:|.|  .|....||:||:..|:::.......:....|::              |.|.|
  Rat   266 SEVVYKTVANL--SGCEASDSEALIRCLRAKSKQEILAINQVFKMI--------------PGVVD 314

  Fly   309 SSSPDRFLEQDIMELMHKKDCLGSMPVIMGYNSAE---------GLAIVVKAKQKLEAYEDDLAR 364
            .    :||.:...||:...| ...:|.|:|.|:.|         ||..::|     :...|.|..
  Rat   315 G----KFLPKHPQELLASGD-FHPVPSIIGVNTDECGLGVPMFMGLDHIIK-----KITRDTLPT 369

  Fly   365 LV---PRNLVLDPQAPEAQEAASDIRAFFFNGQALSKENM-DNLVDLFSDYHFSMDLQRAVEIHA 425
            ::   ...::|.|:       ..|:....:.|.....|.: :...::..|:.|.:.   |:|:..
  Rat   370 VLKSTAAQMMLPPE-------CIDLIMEEYMGDTEDPETLQEQFKEMLGDFMFVIP---ALEVAH 424

  Fly   426 SCQTQSPLYFYRLDYVGGRNLYKKIFQNEDLRGVAHADDICYLFQ--MAGDETEMNRDDLMVTER 488
            ..::|:|:|||...::..   :.|..:...:: ..|.|||.::|.  ..|...::..::.::..|
  Rat   425 FQRSQAPVYFYEFQHLPS---FIKQVRPSHVK-ADHGDDILFVFSSYFWGMNFDITEEEELLKRR 485

  Fly   489 LCEMWANFARDGKPS----PIWKPVKKPHNGEPIQLDCL-LIDRELKMCSNPDGERMDFW 543
            :.:.||||||:|.|:    |.| || ..||.:.:||:.. .:.|.||      ..|:.||
  Rat   486 VMKYWANFARNGNPNSEDLPYW-PV-LDHNEQYLQLNTQPAVGRALK------ARRLQFW 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	161/562 (29%)
Ces2i	XP_008758816.2	COesterase	30..537	CDD:395084	161/563 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010