Protein Alignment clt and CES4A

DIOPT Version :10

• Sequence 1: NP_536784.1
• Gene: clt / 117300
• FlyBaseID: FBgn0000326
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 376
• Identity: 82/376 - (21%)
• Similarity: 122/376 - (32%)
• Gaps: 142/376 - (37%)

  Fly   137 SKNGPSVIVPTPPPIIPPPVIEPSPLADPVPSKSGGGRESVGGA-------SSQHHGSNSQGMGP 194
            |.:.|::|..|.|.|         .::|..|..:...|::|..|       |||...:..|...|
Human   914 SLHHPTLIQSTGPLI---------DMSDIRPGTNPVSRKNVKSAHSTRNRYSSQWTLTKCQASTP 969

  Fly   195 AGIQSSRWPTPGQAQIQQQQPSGTPSSSDRNNGP-SAGTNSGSGGSGSNAASGGSMPSGSQHHNQ 258
            |...:|.|.|.|      .|...|.:.||..:.. |..|:.|.          .||.|
Human   970 ARTLTSDWRTVG------SQHGVTVTESDSYSASLSQDTDKGR----------NSMVS------- 1011

  Fly   259 HHQHQQGSHTRNHSSPYQPPQQQQPHHADRPGSNYDRAPHHQHQQGGLQHG-----------NSY 312
                     |.:.||.|:               ...||..|...:..|||.           :|.
Human  1012 ---------TESASSTYE---------------ELARAYEHAKLEEQLQHAKFEITECFISDSSS 1052

  Fly   313 NQ---SRNQNA-----AYSPSGPG--GLAATGPSSAMADRQNSGGSGGDNYRPPHDGRSGPQQHN 367
            :|   ..|:||     ..:||.||  ...|:.|....|||       |.|...|...|:....:.
Human  1053 DQMTTGTNENADSMTSMSTPSEPGICRFTASPPKPQDADR-------GKNVAVPIPHRANKSDYC 1110

  Fly   368 SMHHHQQTE--------RAP-----------------FHHQQRPSNHHGDRVSGGSSYQPADRG- 406
            ::..:.::|        |.|                 :|.|.|    |       .:..||.:.
Human  1111 NLPLYAKSEAFFRKADGREPCPVVPPREASIRNLARTYHTQAR----H-------LTLDPASKSL 1164

  Fly   407 ---HYGSNSSSDAVSHNSSSTVPPVTTA----PAAVKARSPSPTISESEMA 450
               |.|:.:::      |::|:|..|.|    ||.....:|.||.:|...|
Human  1165 GLPHPGAPAAA------STATLPQRTLAMPAPPAGTAPPAPGPTPAEPPTA 1209

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	alpha/beta hydrolases	22..543	CDD:473884	82/376 (22%)
CES4A	XP_011521323.1	COesterase	50..613	CDD:395084