DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clt and Tg

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_112250.2	Gene:	Tg / 24826	RGDID:	3848	Length:	2768	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	139/517 - (26%)
Similarity:	223/517 - (43%)	Gaps:	100/517 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 QGVLVGRQKKLVNGLEYNSFLGVPYAEPPVGELRFRSPRPLE-----RFQKQELDCSKEGNVSYQ 85
            |.|.||...|.|     ..|||||||.||:.|.||::|..|.     ...|....|.:.|.
  Rat  2215 QVVKVGTAWKQV-----YQFLGVPYAAPPLAENRFQAPEVLNWTGSWDATKLRSSCWQPGT---- 2270

  Fly    86 RDPFTLEVAGSEDCLFLNVYAPKVKSTRTPLPVMVWIHGGGFFFGNG---NSDFHFPAKLMEQEV 147
            |.|...::  |||||:|||:.|  ::..:...|:|:.|......|:|   |.|....|.:  ..:
  Rat  2271 RTPTPPQI--SEDCLYLNVFVP--ENLVSNASVLVFFHNTVEMEGSGGQLNIDGSILAAV--GNL 2329

  Fly   148 IVVTLNYRLGALGFLSLPEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAGG--SS 210
            ||||.|||||..||||...:.:.||.||.||..||.|||.:|.:|.|||..|||..:..|.  :|
  Rat  2330 IVVTANYRLGVFGFLSSGSDEVAGNWGLLDQVAALTWVQTHIGAFGGDPQRVTLAADRGGADVAS 2394

  Fly   211 VHLHTFARHAKRLFHKAIMQSGTA--NMEWVFQNEAPAKTRRLAELLGGGDFGGDSKALLTFLQS 273
            :||........:||.||::..|:|  ....:..:.|..:...||:     :.|..:.::...:..
  Rat  2395 IHLLITRPTRLQLFRKALLMGGSALSPAAIISPDRAQQQAAALAK-----EVGCPNSSVQEVVSC 2454

  Fly   274 EKATPTAIL--ANTLKVLSPDERRRHLPFAF-KPVVEDS---SSPDRFLEQDIMELMHKKDCLGS 332
            .:..|..||  |.| |:|:...     ||.: .|||:..   ..|.|.|::   .|..|.|
  Rat  2455 FRQKPANILNEAQT-KLLAVSG-----PFHYWGPVVDGQYLRELPSRRLKR---PLPVKVD---- 2506

  Fly   333 MPVIMGYNSAEGLAIVVKAKQKLEAYEDDLARLVPRNLVLDPQAPEAQEAASDIRAFFFNGQALS 397
              :::|.:..:||....||.::.|                     |:|...:...||:   |||.
  Rat  2507 --LLIGGSQDDGLINRAKAVKQFE---------------------ESQGRTNSKTAFY---QALQ 2545

  Fly   398 K----ENMDNLVDLFSDYHFSMDLQRAVEIHAS----CQTQSPLYFYRLDYVGGRNLYKK----- 449
            .    |:.|..:...:.:::|  |:.:.:.:||    .:..:..||.....|...:|:.:
  Rat  2546 NSLGGEDSDARILAAAIWYYS--LEHSTDDYASFSRALENATRDYFIICPIVNMASLWARRTRGN 2608

  Fly   450 IFQNEDLRGVAHAD-----DICYLFQM---AGDETEMNRDDLMVTERLCEMWANFARDGKPS 503
            :|.........|..     |:.|.|.:   :..:...:.::..::.::.:.::||.|.|.|:
  Rat  2609 VFMYHVPESYGHGSLELLADVQYAFGLPFYSAYQGYFSMEEQSLSLKVMQYFSNFIRSGNPN 2670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	139/517 (27%)
Tg	NP_112250.2	TY	34..93	CDD:238114
		TY	96..161	CDD:238114
		TY	164..249	CDD:294100
		TY	301..359	CDD:238114
		TY	<613..658	CDD:238114
		TY	661..724	CDD:238114
		TY	730..>776	CDD:294100
		TY	<893..922	CDD:238114
		TY	1005..1074	CDD:238114
		TY	1150..1211	CDD:238114
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1455..1468
		GCC2_GCC3	1464..1509	CDD:285001
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1469..1485
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1486..1502
		TY	1519..1566	CDD:214561
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1602..1722
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1723..1891
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1892..1994
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1995..2127
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	2128..2185
		Cholinesterase-like (ChEL). /evidence=ECO:0000250\|UniProtKB:O08710	2188..2768		139/517 (27%)
		COesterase	2198..2719	CDD:278561	139/517 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2731..2768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000