DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clt and Ces2a

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_653344.1	Gene:	Ces2a / 246252	RGDID:	708353	Length:	558	Species:	Rattus norvegicus

Alignment Length:	590	Identity:	171/590 - (28%)
Similarity:	270/590 - (45%)	Gaps:	119/590 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CGRLIFTRFCSSMKVKVPVK-------QGVLVGRQKKLVNGLEYNSFLGVPYAEPPVGELRFRSP 63
            ||.|:..:.........|::       :|..| ..|...:|:  ::|||:|:|:||||.|||..|
  Rat    15 CGLLLLLQHVHGQDSASPIRNTHTGQVRGSFV-HVKDTKSGI--HTFLGIPFAKPPVGPLRFAPP 76

  Fly    64 RPLERFQK----------------QELDCSKEGNVSYQRDPFTLEVAGSEDCLFLNVYAPKVKST 112
            ...|.:..                ..||..||..::....|.      |||||:||:|.|.....
  Rat    77 EDPEPWSGVRDATSQPAMCLQTDIMNLDGIKEMKLTVHPTPM------SEDCLYLNIYTPAHARE 135

  Fly   113 RTPLPVMVWIHGGGFFFGNGNSDFHFPAKLM--EQEVIVVTLNYRLGALGFLSLPEEGIHGNMGL 175
            .:.|||||||||||...|:.:.:   .|..:  .:|:::|::.||||.|||.|..::...||.|.
  Rat   136 GSNLPVMVWIHGGGLVLGSASMN---DASTLAATEEIVIVSIQYRLGVLGFFSTGDQNARGNWGY 197

  Fly   176 KDQRLALEWVQENIASFNGDPNNVTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEWVF 240
            .||..||.|||:|||.|.|:...||:||.||||:||..|..:..:|.|||.||||||.|.:..:.
  Rat   198 LDQVAALRWVQQNIAYFGGNHGKVTIFGGSAGGTSVSSHVVSPMSKGLFHGAIMQSGVALLPDLI 262

  Fly   241 QNEAPAKTRRLAELLGGGDFGGDSKALLTFLQSEKATPTAILANTLKVLSPDERRRHLPFAFKPV 305
            .:::....:.:|.|  .|....||:||:..|:::.......:....|::              |.
  Rat   263 SDKSEVVYKTVANL--SGCEAPDSEALIRCLRAKSKQEILAINQVFKMI--------------PG 311

  Fly   306 VEDSSSPDRFLEQDIMELMHKKDCLGSMPVIMGYNSAE---------GLAIVVK--AKQKLEAYE 359
            |.|.    :||.:...||:...| ...:|.|:|.|:.|         ||..::|  .::.|..
  Rat   312 VVDG----KFLPKHPQELLASGD-FHPVPSIIGINTDECGWGIPVFLGLDHIIKKITRETLPT-- 369

  Fly   360 DDLARLVPRNLVLDPQAPE--AQEAASDIRAFFFNGQALSKENMDNLVDLF----SDYHFSMDLQ 418
              :.:.....::|.|:..:  .:|...|            .||.:.|.:.|    .|:.|.:.
  Rat   370 --VLKSTAAQMMLPPECIDLIMEEYMGD------------TENPETLQEQFRHMLGDFMFVIP-- 418

  Fly   419 RAVEIHASCQTQSPLYFYRLDYVGGRNLYKKIFQNEDLRGVAHADDI-----CYLFQMAGDETEM 478
             |:::....::|:|:|||...::..   :.|..:...:: ..|.|||     .||:.|..|.||
  Rat   419 -ALQVAHFQRSQAPVYFYEFQHLPS---FIKQVRPSHVK-ADHGDDILFVFGSYLWGMTFDLTE- 477

  Fly   479 NRDDLMVTERLCEMWANFARDGKPS----PIWKPVKKPHNGEPIQLDCL-LIDRELKMCSNPDGE 538
              ::.::..|:.:.||||||.|.|:    |.| || ..|:.:.:||:.. .:.|.||      ..
  Rat   478 --EEELLKRRVMKYWANFARTGNPNGEDLPHW-PV-LDHDEQYLQLNTQPAVGRALK------AR 532

  Fly   539 RMDFW 543
            |:.||
  Rat   533 RLQFW 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	166/572 (29%)
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	166/573 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010