Protein Alignment clt and Nlgn3

DIOPT Version :10

• Sequence 1: NP_536784.1
• Gene: clt / 117300
• FlyBaseID: FBgn0000326
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_766520.2
• Gene: Nlgn3 / 245537
• MGIID: 2444609
• Length: 825
• Species: Mus musculus
• Alignment Length: 593
• Identity: 166/593 - (27%)
• Similarity: 241/593 - (40%)
• Gaps: 179/593 - (30%)

  Fly    12 TRFCSSMKVKVPVKQGVLVGRQKKLVNGLEYNSFLGVPYAEPPVGELRFRSPRP----------- 65
            |.|......:||:...:|.          ..:.:||||||.||:||.||..|.|
Mouse    43 THFGKLRGARVPLPSEILG----------PVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNAT 97

  Fly    66 ------------------LERFQKQELDCSKEGNVSYQRDPFTLEVAGSEDCLFLNVYAPK---- 108
                              |..:....||..    .:|.::|       :||||:||||.|.
Mouse    98 HFPPVCPQNIHTAVPEVMLPVWFTANLDIV----ATYIQEP-------NEDCLYLNVYVPTEDGS 151

  Fly   109 -VKSTRTPL-----------------PVMVWIHGGGFFFGNGNSDFHFPAKLMEQ--EVIVVTLN 153
             .|.....|                 ||||:||||.:..|.||.   ....::..  .|||:|||
Mouse   152 GAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNM---IDGSVLASYGNVIVITLN 213

  Fly   154 YRLGALGFLSLPEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAGGSSVHLHTFAR 218
            ||:|.|||||..::...||.||.||..||.||.||||.|.|||..:|:||...|.|.|.|.|.:.
Mouse   214 YRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSH 278

  Fly   219 HAKRLFHKAIMQSGTANMEWVFQNEAPAK-TRRLAELLGGGDFGGDSKALLTFLQSEKATPTAIL 282
            |::.||.:||:|||:|...|.. |..|.| |..||:.:|....  |:..::..|:.:.|.
Mouse   279 HSEGLFQRAIIQSGSALSSWAV-NYQPVKYTSLLADKVGCNVL--DTVDMVDCLRQKSAK----- 335

  Fly   283 ANTLKVLSPDERRRHLPFAFKPVVEDSSSPD---------RFLEQDIMELMHKKDCLGSMPVIMG 338
                :::..|.:......||.||::....||         .||..|||               :|
Mouse   336 ----ELVEQDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFLNYDIM---------------LG 381

  Fly   339 YNSAEGLAIVVKAKQKLEAYEDDLARLVPRNLVLDPQ---------------------APEAQEA 382
            .|..|||..|                    ..|:||:                     .||.::.
Mouse   382 VNQGEGLKFV--------------------EGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDT 426

  Fly   383 ASDIRAFFFNGQALSKENMD----NLVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFYRLDYVGG 443
            ..:...|.:...| .::|.:    .||.||:|:.:........::||  :..||.|||.. |...
Mouse   427 LRETIKFMYTDWA-DRDNPETRRKTLVALFTDHQWVEPSVVTADLHA--RYGSPTYFYAF-YHHC 487

  Fly   444 RNLYKKIFQNEDLRGVAHADDICYLF--QMAGDETEM-----NRDDLMVTERLCEMWANFARDGK 501
            ::|.|..:.:     .||.|::.|:|  .|.| .|::     :::|:|::..:...|.|||:.|.
Mouse   488 QSLMKPAWSD-----AAHGDEVPYVFGVPMVG-PTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGD 546

  Fly   502 PSPIWKPV 509
            |:   |||
Mouse   547 PN---KPV 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	alpha/beta hydrolases	22..543	CDD:473884	164/583 (28%)
Nlgn3	NP_766520.2	COesterase	37..601	CDD:395084	166/593 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	151..172		2/20 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	622..668