DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment clt and Cel

DIOPT Version :9

Sequence 1:NP_536784.1 Gene:clt / 117300 FlyBaseID:FBgn0000326 Length:562 Species:Drosophila melanogaster
Sequence 2:NP_058693.2 Gene:Cel / 24254 RGDID:2331 Length:612 Species:Rattus norvegicus


Alignment Length:597 Identity:175/597 - (29%)
Similarity:259/597 - (43%) Gaps:123/597 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 CSSMKVKVPVKQGVLVGRQKK--LVNGLEYNSFLGVPYA-----EPPVGELRFRSPRPLERFQKQ 72
            |::....|..:.|.:.|..||  |:.|...:.|.|:|:|     |.|.....::.......|:|:
  Rat    19 CAAKLGAVYTEGGFVEGVNKKLSLLGGDSVDIFKGIPFATAKTLENPQRHPGWQGTLKATDFKKR 83

  Fly    73 ELDCSKEGNVSYQRDPFTLEVAGSEDCLFLNVYAPK-VKSTRTPLPVMVWIHGGGFFFGNGNSDF 136
            .|..:...:.:|          |.||||:||::.|: .|.....|||||||:||.|..|:|....
  Rat    84 CLQATITQDDTY----------GQEDCLYLNIWVPQGRKQVSHDLPVMVWIYGGAFLMGSGQGAN 138

  Fly   137 HFPAKLMEQE-------VIVVTLNYRLGALGFLSLPEEGIHGNMGLKDQRLALEWVQENIASFNG 194
            .....|.:.|       |||||.|||:|.|||||..:..:.||.||:||.:|:.||:.|||:|.|
  Rat   139 FLKNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNFGLRDQHMAIAWVKRNIAAFGG 203

  Fly   195 DPNNVTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEWVFQNEAP---AKTRRLAELLG 256
            ||:|:|:||||||.:||.|.|.:.:.|.|..:||.|||.|...|..| |.|   |||  :|:.:|
  Rat   204 DPDNITIFGESAGAASVSLQTLSPYNKGLIRRAISQSGVALSPWAIQ-ENPLFWAKT--IAKKVG 265

  Fly   257 GGDFGGDSKALLTFLQSEKATPTAILANTLKVLSPDE---------RRRHLP----FAFKPVVED 308
            .                 ....||.:|..||:..|..         :.:..|    .||.|||:.
  Rat   266 C-----------------PTEDTAKMAGCLKITDPRALTLAYRLPLKSQEYPIVHYLAFIPVVDG 313

  Fly   309 SSSPDRFLEQDIMELMHKKDCLGSMPVIMGYNSAEG-------LAIVVKAKQKLEAYEDDLARLV 366
            ...||     |.:.|.   |....:..:.|.|..:|       :..:.||||  :..|:|..|||
  Rat   314 DFIPD-----DPINLY---DNAADIDYLAGINDMDGHLFATVDVPAIDKAKQ--DVTEEDFYRLV 368

  Fly   367 PRNLVLDPQAPEAQEAASDIRAFFFNGQALSKENMDNLVDLF-SDYHFSMDLQRAVEIHASCQTQ 430
            ..:.|  .:..:..:|..||....: .|..|:|||...|..| :|..|.:..:.|:..|.:....
  Rat   369 SGHTV--AKGLKGTQATFDIYTESW-AQDPSQENMKKTVVAFETDILFLIPTEMALAQHRAHAKS 430

  Fly   431 SPLYFYRLDYVGGRNLYKKIFQNEDLRGVAHADDICYLF---------QMAGDETEMNRDDLMVT 486
            :..|.|...:.....:|.|      ..|..||||:.|:|         ..|.|.|        |:
  Rat   431 AKTYSYLFSHPSRMPIYPK------WMGADHADDLQYVFGKPFATPLGYRAQDRT--------VS 481

  Fly   487 ERLCEMWANFARDGKP----SPI---WKPVKKPHNGEPIQLDCLLIDRELKMCSNPDGERMDFWR 544
            :.:...|.|||:.|.|    ||:   |.|. ...||..:.::..:....:|          :..|
  Rat   482 KAMIAYWTNFAKSGDPNMGNSPVPTHWYPY-TTENGNYLDINKKITSTSMK----------EHLR 535

  Fly   545 SMYRRYRSENFE 556
            ..:.::.:..||
  Rat   536 EKFLKFWAVTFE 547

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cltNP_536784.1 COesterase 22..543 CDD:278561 171/575 (30%)
CelNP_058693.2 COesterase 26..542 CDD:278561 172/583 (30%)
Aes <118..>247 CDD:223730 64/128 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 553..612
4 X 11 AA tandem repeats, O-glycosylated region 556..599
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000017
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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