DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment clt and Ces4a

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_666325.2	Gene:	Ces4a / 234677	MGIID:	2384581	Length:	563	Species:	Mus musculus

Alignment Length:	584	Identity:	166/584 - (28%)
Similarity:	256/584 - (43%)	Gaps:	92/584 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LIFTRFCSSMKVKVPV---KQGVLVGRQKKLVNGLEYNSFLGVPYAEPPVGELRFRSPRP----- 65
            |:......::..|.|:   |.|:|.|:|.. |.......|||:|:::||||..||..|.|
Mouse    20 LVVQTALGALHTKEPLLITKHGILQGKQVH-VGDTPIQVFLGIPFSKPPVGTRRFAPPEPPLPWN 83

  Fly    66 ------------LERFQKQELDCSKEGNVSYQRDPFTLEVAGSEDCLFLNVYAPKVKSTRTPLPV 118
                        |:....|.|.........|:...|      |||||:||||||.:......|||
Mouse    84 GIRDATTYPPSCLQESWGQILSMYLNTRKQYKWLHF------SEDCLYLNVYAPVLAPGAPLLPV 142

  Fly   119 MVWIHGGGFFFGNGNSDFHFPAKLMEQEVIVVTLNYRLGALGFLSLPEEGIHGNMGLKDQRLALE 183
            |||..||.|..|:. |.:.........:|::|.|.||||.|||.|.......||.||.||..||.
Mouse   143 MVWFPGGAFLAGSA-STYEGSELAARGKVVLVFLQYRLGILGFFSTGNSHARGNWGLLDQIAALR 206

  Fly   184 WVQENIASFNGDPNNVTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEWVFQNEAPAKT 248
            ||||||.:|.|||::|||||:|||..||.....:..|:.|||:||.|||||.::.....:.....
Mouse   207 WVQENIEAFGGDPDSVTLFGQSAGAMSVSGLMVSPLAQGLFHQAISQSGTAVLKAFITPDPLTSA 271

  Fly   249 RRLAELLGGGDFGGDSKALLTFLQSEKATPTAILANTLKVLSPDERR--RHLPFAFKPVVEDSSS 311
            :::|.|.|...  ..:|.::..|:|..|....:::..:.....:..:  :.:.:...|||:....
Mouse   272 KKIAHLAGCDH--NSTKVMVECLRSLSAEEVTLVSKRMSFFQANSHKDPKEIVWFLSPVVDGVVF 334

  Fly   312 PDRFLEQDIMELMHKKDCLGSMPVIMGYNSAE---GLAIVVKAK--QKLEAYEDDLARLVPRNLV 371
            |     :|.:.|:.:.. :..:|.::|.|:||   .|..::|.:  |::....:....|...|::
Mouse   335 P-----EDPVVLLTRGQ-VKPVPYLLGVNNAEFEWNLPFLMKIQLNQRMMNQTNINKILWSFNVL 393

  Fly   372 LD---PQAP-EAQEAASDIRAFFFNGQALSKEN----MDNLVDLFSDYHFSMDLQRAVEIHASCQ 428
            |:   .|.| .|:|..:|         |:|..:    .:.|:||..|..|.....:|...|.  .
Mouse   394 LNITKEQVPVVAREYLND---------AISNHDWKMFRNRLIDLIGDATFVYATLQAARYHR--D 447

  Fly   429 TQSPLYFYRLDYVGGRNLYKKIFQNEDLRGVAHADDICYLF-------QMAGDETEMNRDDLMVT 486
            ..||:|.|...:.....:..|.:...|     |.|::.|||       ..||:|.|.:.
Mouse   448 AGSPVYLYEFKHHASSGIIIKPYNGAD-----HGDELSYLFGSPFSKGSSAGEEKEFSL------ 501

  Fly   487 ERLCEMWANFARDGKPS----PIWKPVKKPHNGEPIQLDCLLIDRELKMCSNPDGERMDFWRSM 546
             ::.:.|||||..|.|:    |.|....|...       .|.:|.:.::......::|.||..:
Mouse   502 -QMMKYWANFAHTGNPNGEKLPYWPRFDKDEK-------YLQLDFDTRVGVKLKEKKMAFWSQL 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	162/566 (29%)
Ces4a	NP_666325.2	COesterase	30..554	CDD:278561	163/569 (29%)
Ces4a	NP_666325.2	Aes	<128..>272	CDD:223730	65/144 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920