DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment clt and Ces2c

DIOPT Version :9

Sequence 1:NP_536784.1 Gene:clt / 117300 FlyBaseID:FBgn0000326 Length:562 Species:Drosophila melanogaster
Sequence 2:NP_663578.1 Gene:Ces2c / 234671 MGIID:2385905 Length:561 Species:Mus musculus


Alignment Length:546 Identity:162/546 - (29%)
Similarity:255/546 - (46%) Gaps:108/546 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 NSFLGVPYAEPPVGELRFRSPRPLERFQ------------KQELDCSKEG---NVSYQRDPFTLE 92
            ::|||:|:|:||||.|||..|...|.:.            .|.||...|.   ::......|.: 
Mouse    58 HTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTAHPAMCLQNLDMLNEAGLPDMKMMLSSFPM- 121

  Fly    93 VAGSEDCLFLNVYAPKVKSTRTPLPVMVWIHGGGFFFGNGNSDFHFPAKLM--EQEVIVVTLNYR 155
               |||||:||:|.|......:.||||||||||....|..:.   |...|:  .::::|||:.||
Mouse   122 ---SEDCLYLNIYTPAHAHEGSNLPVMVWIHGGALVIGMASM---FDGSLLTVNEDLVVVTIQYR 180

  Fly   156 LGALGFLSLPEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAGGSSVHLHTFARHA 220
            ||.|||.|..::...||.|..||..||.|||:|||.|.|:|:.||:|||||||:||..|..:..:
Mouse   181 LGVLGFFSTGDQHARGNWGYLDQAAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSHVVSPMS 245

  Fly   221 KRLFHKAIMQSGTANMEWVFQNEAPAKTRRLAELLGGGDFGGDSKALLTFLQSEKATPTAILANT 285
            :.|||.|||:||.|.:..:....:...:..:|:|  .|....||:||:..|:.:.......:...
Mouse   246 QGLFHGAIMESGVALLPDLISETSEMVSTTVAKL--SGCEAMDSQALVRCLRGKSEAEILAINKV 308

  Fly   286 LKVLSPDERRRHLPFAFKPVVEDSSSPDRFLEQDIMELMHKKDCLGSMPVIMGYNSAE------- 343
            .|::              |.|.|.    .|..:...||:..:| ...:|.|:|.|:.|       
Mouse   309 FKMI--------------PAVVDG----EFFPRHPKELLASED-FHPVPSIIGVNNDEFGWSIPV 354

  Fly   344 --GLAIVVK--AKQKLEAYEDDLARLVPRNLVLDPQAPEAQEAASDIRAFFFNGQALSKENMD-N 403
              |.|.::|  .::.|:|...|.|    ..::|.|:       .||:....:.|.....:.:. .
Mouse   355 VMGSAQMIKGITRENLQAVLKDTA----VQMMLPPE-------CSDLLMEEYMGDTEDAQTLQIQ 408

  Fly   404 LVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFYRLDYVGGRNLYKKIFQN-----EDLR----GV 459
            ..::..|:.|.:.   |:::....::.:|:|||.             ||:     :|:|    ..
Mouse   409 FTEMMGDFMFVIP---ALQVAHFQRSHAPVYFYE-------------FQHPPSYFKDVRPPHVKA 457

  Fly   460 AHADDICYLFQ--MAGDETEMNRDDLMVTERLCEMWANFARDGKPS----PIWKPVKKPHNGEPI 518
            .|||:|.::|.  ..|.:.:...::.:::.|:.:.||||||.|.|:    |.| || ..|:.:.:
Mouse   458 DHADEIPFVFASFFWGMKLDFTEEEELLSRRMMKYWANFARHGNPNSEGLPYW-PV-MDHDEQYL 520

  Fly   519 QLDCL-LIDRELKMCSNPDGERMDFW 543
            |||.. .:.|.||      ..|:.||
Mouse   521 QLDIQPAVGRALK------AGRLQFW 540

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cltNP_536784.1 COesterase 22..543 CDD:278561 160/544 (29%)
Ces2cNP_663578.1 COesterase 31..540 CDD:278561 160/544 (29%)
Aes <130..>233 CDD:223730 49/105 (47%)
Prevents secretion from ER. /evidence=ECO:0000255 558..561
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1516
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000017
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11559
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.910

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