DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clt and Ces2b

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_937814.1	Gene:	Ces2b / 234669	MGIID:	2448547	Length:	556	Species:	Mus musculus

Alignment Length:	559	Identity:	168/559 - (30%)
Similarity:	266/559 - (47%)	Gaps:	109/559 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 NSFLGVPYAEPPVGELRFRSPRPLERFQ------------KQELDCSKEGNVSYQRDPFTLEVAG 95
            ::|||:|:|:||||.|||..|...|.:.            .|.|...||  :..:..|    |:.
Mouse    58 HTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTAHPAMCLQNLGVMKE--IKLKLPP----VST 116

  Fly    96 SEDCLFLNVYAPKVKSTRTPLPVMVWIHGGGFFFGNGNSDFHFPAKLME--QEVIVVTLNYRLGA 158
            |||||:||:|.|......:.|||||||||||...|..:.   :...|:.  ::::|||:.||||.
Mouse   117 SEDCLYLNIYTPAHAHEGSNLPVMVWIHGGGLVAGMASM---YDGSLLAAIEDLVVVTIQYRLGV 178

  Fly   159 LGFLSLPEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAGGSSVHLHTFARHAKRL 223
            |||.|..::...||.|..||..||.|:|:|||.|.|.|:.||:|||||||:||..|..:..:|.|
Mouse   179 LGFFSTGDQHARGNWGFLDQVAALRWIQQNIAHFGGKPDRVTIFGESAGGTSVSSHVVSPMSKGL 243

  Fly   224 FHKAIMQSGTANMEWVFQNEAPAKTRRLAELLGGGDFGGDSKALLTFLQSEKATPTAILANTLKV 288
            ||.|||:||.|.:.::..:.:...:..:|:|  .|....||:||:..|:. |:....:..|.|..
Mouse   244 FHGAIMESGVALLPYLITDTSEMVSTTVAKL--SGCEAMDSEALVRCLRG-KSEAEILAINKLVQ 305

  Fly   289 LSPDERRRHLPFAFKPVVEDSSSPDRFLEQDIMELMHKKDCLGS-----MPVIMGYNSAE---GL 345
            :.|            .||:....|           .|.|:.|.|     :|.|:|.|:.|   .:
Mouse   306 MIP------------AVVDGEFFP-----------RHPKELLASEDFHPVPSIIGVNNDEFGWTI 347

  Fly   346 AIVVKAKQKLEAYEDDLARLVPRN----LVLDPQAPEAQEAASDIRAFFFNGQALSKENMD-NLV 405
            .:|:.:.|.::....:..:.|.:|    |:|.|:       .||:....:.|.....:.:. ...
Mouse   348 PVVMGSAQTIKEITRENLQAVLKNTTAQLMLPPE-------CSDLLMEEYMGDTEDAQTLQIQFT 405

  Fly   406 DLFSDYHFSMDLQRAVEIHASCQTQSPLYFYRLDYVGGRNLYKKIFQNEDLR----GVAHADDIC 466
            ::..|:.|.:.   |:::....::.:.:|||...:        :|...:|:|    ...|||:|.
Mouse   406 EMMEDFMFVIP---ALQVAYFQRSHASVYFYEFQH--------QIASLKDVRPTHVKADHADEIP 459

  Fly   467 YLF-----QMAGDETEMNRDDLMVTERLCEMWANFARDGKPS----PIWKPVKKPHNGEPIQLDC 522
            ::|     .|..|.||   .:.:::.|:.:.||||||.|.|:    |.| || ..|:.:.:|||.
Mouse   460 FVFGYFFWDMKLDFTE---GEKLLSRRMMKYWANFARHGNPNSEGLPYW-PV-MDHDEQYLQLDT 519

  Fly   523 L-LIDRELKMCSNPDGERMDFWRSMYRRYRSENFEAVRA 560
            . .:.|.||      ..|:.||    .:..|:..:.:||
Mouse   520 QPAVGRALK------SRRLQFW----TKTLSQKIQELRA 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	163/540 (30%)
Ces2b	NP_937814.1	COesterase	34..535	CDD:365897	163/540 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910