DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment clt and Nlgn2

DIOPT Version :9

Sequence 1:NP_536784.1 Gene:clt / 117300 FlyBaseID:FBgn0000326 Length:562 Species:Drosophila melanogaster
Sequence 2:NP_001351066.1 Gene:Nlgn2 / 216856 MGIID:2681835 Length:836 Species:Mus musculus


Alignment Length:582 Identity:174/582 - (29%)
Similarity:257/582 - (44%) Gaps:132/582 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 FLGVPYAEPPVGELRFRSPRPLERFQKQELDCSKEGNVSYQRDP-------------------FT 90
            |||||||.||:|..||:.|         |...|..|..:....|                   ||
Mouse    69 FLGVPYATPPLGARRFQPP---------EAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFT 124

  Fly    91 --LEVAG------SEDCLFLNVYAP---------KVKSTRTP----------LPVMVWIHGGGFF 128
              ||.|.      |||||:||:|.|         :.::|..|          .|||:::|||.:.
Mouse   125 DNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDSGKKPVMLFLHGGSYM 189

  Fly   129 FGNGNSDFHFPAKLMEQ--EVIVVTLNYRLGALGFLSLPEEGIHGNMGLKDQRLALEWVQENIAS 191
            .|.||.   |...::..  .|||||||||||.|||||..::...||.||.||..||.|:.||||.
Mouse   190 EGTGNM---FDGSVLAAYGNVIVVTLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAH 251

  Fly   192 FNGDPNNVTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEWVFQNEAPAKTRRLAELLG 256
            |.|||..:|:||..||.|.|:|...:.|::.||.|||.|||||...|.. |..|.|..||.....
Mouse   252 FGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSV-NYQPLKYTRLLAAKV 315

  Fly   257 GGDFGGDSKALLTFLQSEKATPTAILANTLKVLSPDERRRHLPFAFKPVVEDSSSPDRFLEQDIM 321
            |.| ..||...:..|:.:         ::.:::..|.:......||.|||:....||     |..
Mouse   316 GCD-REDSTEAVECLRRK---------SSRELVDQDVQPARYHIAFGPVVDGDVVPD-----DPE 365

  Fly   322 ELMHKKDCLGSMPVIMGYNSAEGLAIVVKAKQ-----KLEAYEDDLARLVPRNLVLDPQAPEAQE 381
            .||.:.:.| :..:::|.|..|||..|..:.:     ...|::..::..|. ||.   ..||.::
Mouse   366 ILMQQGEFL-NYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFVD-NLY---GYPEGKD 425

  Fly   382 AASDIRAFFF-------NGQALSKENMDNLVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFYRLD 439
            ...:...|.:       ||:...|    .|:.||:|:.:........::||  ..|||:|||...
Mouse   426 VLRETIKFMYTDWADRDNGEMRRK----TLLALFTDHQWVAPAVATAKLHA--DYQSPVYFYTFY 484

  Fly   440 Y---VGGRNLYKKIFQNEDLRGVAHADDICYLF--QMAGDETEM-----NRDDLMVTERLCEMWA 494
            :   ..||         .:....||.|::.|:|  .|.| .|::     :::|:|::..:...|.
Mouse   485 HHCQAEGR---------PEWADAAHGDELPYVFGVPMVG-ATDLFPCNFSKNDVMLSAVVMTYWT 539

  Fly   495 NFARDGKPS-PIWKPVK----KPHNGEPI--------QLDCLLIDRELKMCSNPDGERMDFW 543
            |||:.|.|: |:.:..|    ||:..|.:        :...|.|..:.::..|....::.||
Mouse   540 NFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFW 601

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cltNP_536784.1 COesterase 22..543 CDD:278561 172/580 (30%)
Nlgn2NP_001351066.1 COesterase 42..601 CDD:306613 172/580 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 623..661
Required for interaction with LHFPL4. /evidence=ECO:0000269|PubMed:28279354 679..699
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 711..735
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 791..836
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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