DRSC/TRiP Functional Genomics Resources

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Protein Alignment clt and Nlgn2

DIOPT Version :10

Sequence 1:NP_536784.1 Gene:clt / 117300 FlyBaseID:FBgn0000326 Length:562 Species:Drosophila melanogaster
Sequence 2:NP_942562.2 Gene:Nlgn2 / 216856 MGIID:2681835 Length:836 Species:Mus musculus


Alignment Length:582 Identity:174/582 - (29%)
Similarity:257/582 - (44%) Gaps:132/582 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 FLGVPYAEPPVGELRFRSPRPLERFQKQELDCSKEGNVSYQRDP-------------------FT 90
            |||||||.||:|..||:.|         |...|..|..:....|                   ||
Mouse    69 FLGVPYATPPLGARRFQPP---------EAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFT 124

  Fly    91 --LEVAG------SEDCLFLNVYAP---------KVKSTRTP----------LPVMVWIHGGGFF 128
              ||.|.      |||||:||:|.|         :.::|..|          .|||:::|||.:.
Mouse   125 DNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDSGKKPVMLFLHGGSYM 189

  Fly   129 FGNGNSDFHFPAKLMEQ--EVIVVTLNYRLGALGFLSLPEEGIHGNMGLKDQRLALEWVQENIAS 191
            .|.||.   |...::..  .|||||||||||.|||||..::...||.||.||..||.|:.||||.
Mouse   190 EGTGNM---FDGSVLAAYGNVIVVTLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAH 251

  Fly   192 FNGDPNNVTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEWVFQNEAPAKTRRLAELLG 256
            |.|||..:|:||..||.|.|:|...:.|::.||.|||.|||||...|.. |..|.|..||.....
Mouse   252 FGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSV-NYQPLKYTRLLAAKV 315

  Fly   257 GGDFGGDSKALLTFLQSEKATPTAILANTLKVLSPDERRRHLPFAFKPVVEDSSSPDRFLEQDIM 321
            |.| ..||...:..|:.:         ::.:::..|.:......||.|||:....||     |..
Mouse   316 GCD-REDSTEAVECLRRK---------SSRELVDQDVQPARYHIAFGPVVDGDVVPD-----DPE 365

  Fly   322 ELMHKKDCLGSMPVIMGYNSAEGLAIVVKAKQ-----KLEAYEDDLARLVPRNLVLDPQAPEAQE 381
            .||.:.:.| :..:::|.|..|||..|..:.:     ...|::..::..|. ||.   ..||.::
Mouse   366 ILMQQGEFL-NYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFVD-NLY---GYPEGKD 425

  Fly   382 AASDIRAFFF-------NGQALSKENMDNLVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFYRLD 439
            ...:...|.:       ||:...|    .|:.||:|:.:........::||  ..|||:|||...
Mouse   426 VLRETIKFMYTDWADRDNGEMRRK----TLLALFTDHQWVAPAVATAKLHA--DYQSPVYFYTFY 484

  Fly   440 Y---VGGRNLYKKIFQNEDLRGVAHADDICYLF--QMAGDETEM-----NRDDLMVTERLCEMWA 494
            :   ..||         .:....||.|::.|:|  .|.| .|::     :::|:|::..:...|.
Mouse   485 HHCQAEGR---------PEWADAAHGDELPYVFGVPMVG-ATDLFPCNFSKNDVMLSAVVMTYWT 539

  Fly   495 NFARDGKPS-PIWKPVK----KPHNGEPI--------QLDCLLIDRELKMCSNPDGERMDFW 543
            |||:.|.|: |:.:..|    ||:..|.:        :...|.|..:.::..|....::.||
Mouse   540 NFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFW 601

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cltNP_536784.1 alpha/beta hydrolases 22..543 CDD:473884 172/580 (30%)
Nlgn2NP_942562.2 COesterase 42..601 CDD:395084 172/580 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 623..661
Required for interaction with LHFPL4. /evidence=ECO:0000269|PubMed:28279354 679..699
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 711..735
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 791..836
Blue background indicates that the domain is not in the aligned region.

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