DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment clt and Ces2e

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001093947.1	Gene:	Ces2e / 192257	RGDID:	621563	Length:	557	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	162/534 - (30%)
Similarity:	256/534 - (47%)	Gaps:	86/534 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 NSFLGVPYAEPPVGELRFRSPRPLERFQ------------KQELDCSKEGN--VSYQRDPFTLEV 93
            ::|||:|:|:||:|.|||..|.|.|.:.            .|.:|.....|  :...|.|    |
  Rat    56 HTFLGIPFAKPPIGPLRFAPPEPPEPWSGVRDGTSHPAMCLQNIDGLNLENLKIKMSRSP----V 116

  Fly    94 AGSEDCLFLNVYAPKVKSTRTPLPVMVWIHGGGFFFGNGNSDFHFPAKLME--QEVIVVTLNYRL 156
            :.|||||:|::|.|......:.|||||||||||..:|..::   :...::.  ::|:|||:.|||
  Rat   117 SMSEDCLYLSIYTPAHTHKDSNLPVMVWIHGGGLCWGMAST---YDGSMLAAIEDVVVVTIQYRL 178

  Fly   157 GALGFLSLPEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAGGSSVHLHTFARHAK 221
            |.|||.|..:|...||.|..||..||.|||:||..|.|:|:.||:|||||||.||..|..:..::
  Rat   179 GILGFFSTGDEHARGNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGISVSSHVVSPMSQ 243

  Fly   222 RLFHKAIMQSGTANMEWVFQNEAPAKTRRLAELLGGGDFGGDSKALLTFLQSEKATPTAILANTL 286
            .|||.|||:||.|.:..:..|.:......:|.|.|....  ||:||::.|:.:.......:.|.:
  Rat   244 GLFHGAIMESGVALLPNLISNTSEVIYTMVANLSGCEPV--DSEALMSCLREKSEEEMLAINNIV 306

  Fly   287 KVLSPDERRRHLPFAFKPVVEDSSSPDRFLEQDIMELMHKKDCLGSMPVIMGYNSAE-GLAI-VV 349
            :.:|             .||:     .:||.:..:||:...| ...:|.|:|.||.| |..| ::
  Rat   307 RTIS-------------GVVD-----GKFLPRHPLELLASVD-FHPVPSIIGINSDEYGWIIPML 352

  Fly   350 KAKQKLEAYEDDLARLVPRNLVLDPQAPEAQEAASDIRAFFFNGQALSKENMD-NLVDLFSDYHF 413
            .....::....:..|.|.:|..:....|   ...||:....:.|.....:.:. ...::..|:.|
  Rat   353 HPDSTMKEINRETMRAVLKNTAVQMMLP---PECSDLLMEEYMGDTEDSKTLQIQFNEMMGDFIF 414

  Fly   414 SMDLQRAVEIHASCQTQSPLYFYRLDYVGGRNLYKKIFQNEDLR----GVAHADD----ICYLF- 469
            .:.   |:::....::.:|:|||...:..  |..|      |:|    ...|.|:    |.|||
  Rat   415 VIP---ALQVAHFQRSHAPVYFYEFQHQS--NFLK------DIRPPHVKADHGDELPYVIGYLFW 468

  Fly   470 QMAGDETEMNRDDLMVTERLCEMWANFARDGKPS----PIWKPVKKPHNGEPIQLDCL-LIDREL 529
            .|....||   ::.:::.::.:.||||||.|.|:    |.|..:  .|:.:.:|||.. ::.|.|
  Rat   469 DMKFVFTE---EEKLLSRKMIKYWANFARHGNPNSEGLPYWPAL--DHDEQYLQLDIQPVVGRAL 528

  Fly   530 KMCSNPDGERMDFW 543
            |      ..|:.||
  Rat   529 K------ARRLKFW 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	160/532 (30%)
Ces2e	NP_001093947.1	COesterase	30..536	CDD:278561	160/532 (30%)
Ces2e	NP_001093947.1	Aes	<127..>230	CDD:223730	49/105 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910