Protein Alignment clt and cest-8

DIOPT Version :10

• Sequence 1: NP_536784.1
• Gene: clt / 117300
• FlyBaseID: FBgn0000326
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_001359583.1
• Gene: cest-8 / 182818
• WormBaseID: WBGene00007691
• Length: 605
• Species: Caenorhabditis elegans
• Alignment Length: 539
• Identity: 128/539 - (23%)
• Similarity: 212/539 - (39%)
• Gaps: 125/539 - (23%)

  Fly    44 SFLGVPYAEPPVGELRFRSPRPLERFQKQELDCSKEGNVSYQRDPFTLEVAGSEDCLFLNVYAPK 108
            :|..||:|:||:|.|||..|:.|:.:. ..||.|............|.:...:||||::|::..:
 Worm    43 TFKSVPFAKPPIGNLRFAPPQKLDHWD-GILDASVYSAACMSNSTLTTQSYVNEDCLYINIFTSE 106

  Fly   109 VKSTRTPLPVMVWIHGGGFFFGNGN--SDFHFPAKLMEQEVIVVTLNYRLGALGFLSL-PEEGIH 170
             |..::...|:|:.|||.:...:..  ||.....:.:.::||.|....|||..|.|.. |...:.
 Worm   107 -KCLKSKCSVIVYFHGGAYNTESATMFSDRFILDRYVHEDVIFVIPAVRLGVFGQLYFGPNAYLT 170

  Fly   171 GNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAGGSSVHLHTFARHAK---RLFHKAIMQSG 232
            .|:.:.|..|||::|...|::|.|||..||:.|.|:||:.|....|:....   :||.:.||.|.
 Worm   171 ENLFMFDAILALDFVHNEISNFGGDPEKVTIMGHSSGGTLVEALGFSSMVDPELKLFQQMIMLSS 235

  Fly   233 TANMEWVFQNEAPAKTRRLAELLGGGDFGGDSKAL-LTFLQSEKA---TPTAILANTLKVLSPDE 293
            |                        |.||.|...: .:|...||.   ..|....||:.|....:
 Worm   236 T------------------------GMFGFDDLVIDNSFTIVEKLGCFNGTKEERNTVNVAETLD 276

  Fly   294 RRRHL----------------PFAFKPVVEDSSSPDRFLEQDIMELMHKKDCLGSMP--VIMGYN 340
            ..||:                ..:||.::.  .:|...|..:|.:|  ||:   :.|  .|.|..
 Worm   277 CMRHIDGYEILRVQQKMELMDQLSFKYLLR--GAPFMLLNGNIADL--KKN---TSPRNAIFGTT 334

  Fly   341 SAEGLAIVVK---AKQKLEAYEDDLARLVPRNLVLDPQAPEAQEAASDIRAFFFNGQALSKENMD 402
            ..|...:..|   .......||:.:|  |.||                     ::|:.:  :||:
 Worm   335 EHEFFDVTEKYLYITVTFLDYENPVA--VARN---------------------YDGRLM--KNME 374

  Fly   403 NLVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFYRLDYVGGRNLYKKIFQNEDLRGVAHADDICY 467
            .::        :.|........|:|.....        ..|.:::  :|:......| |..|:.|
 Worm   375 TMI--------TGDSAAIFVSTATCAAAMA--------NAGADVF--LFETRQSYSV-HVSDMQY 420

  Fly   468 LFQMAGDETEMNRD-DLMVTERL-CEMWANFARDGKPSPIWKPVKKPHNGEPIQLDCLLIDRELK 530
            ..   |:....||. |:.:.:.. .::..||.:.|||||.|.||      :|.:::.|.:..:.|
 Worm   421 FI---GNHCAHNRTIDIDILDSFYSKLLTNFTKHGKPSPGWDPV------DPGRMNYLELKVDSK 476

  Fly   531 MCSNP------DGERMDFW 543
            ..|.|      ..:.:.||
 Worm   477 ARSGPVMLEGYHAKDVSFW 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	alpha/beta hydrolases	22..543	CDD:473884	126/537 (23%)
cest-8	NP_001359583.1	alpha/beta hydrolases	19..495	CDD:473884	126/537 (23%)