DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clt and cest-30

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_504407.1	Gene:	cest-30 / 181871	WormBaseID:	WBGene00015071	Length:	578	Species:	Caenorhabditis elegans

Alignment Length:	555	Identity:	155/555 - (27%)
Similarity:	250/555 - (45%)	Gaps:	104/555 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLRPCGRLIFTRFCSSMKVKVPVKQGVLVGRQ-KKLVNGLEYNSFLGVPYAEPPVGELRFRSPR 64
            :|..|||               |::..:...:. .|:|:|     :||:|:|:.|||.|:|:.|.
Worm    33 ILNAPCG---------------PIRGNIYKHKNGTKIVDG-----YLGIPFAKAPVGALKFKKPV 77

  Fly    65 PLERFQKQELDCSKEGNVSYQRDPFTLEVAGS------EDCLFLNVYAPKVKSTRTP--LPVMVW 121
            ..|::.:.. ||.:.|....|...|....|.|      |:||.|||:||:.|....|  |||:|:
Worm    78 AAEKWTEPR-DCYEYGPGCPQTGRFAALTAKSTAAFAEENCLTLNVFAPRWKLAEFPKGLPVLVY 141

  Fly   122 IHGGGFFFG--NGNSDFHFPAKLMEQEVIVVTLNYRLGALGFLSLPEEGIHGNMGLKDQRLALEW 184
            |:|||:..|  :...|:.....|..::|||||:|||||.||||::.:...:||.||.||.|||:|
Worm   142 IYGGGYEIGFTSYMDDYSLTGTLPLKDVIVVTMNYRLGPLGFLTIADGIANGNYGLWDQTLALQW 206

  Fly   185 VQENIASFNGDPNNVTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEWVF--QNEAPAK 247
            ||:|||||.|:|.:|||.|.|||.:|....:.:.|:.:||.::|..||||...:..  ::.....
Worm   207 VQDNIASFGGNPESVTLSGTSAGATSTDFLSLSPHSNQLFQRSISMSGTAFCNFAIRPKDVEVGV 271

  Fly   248 TRRLAELLGGGDFGGDSKALLTFLQSE---KATPTAILANTLKVLSPDERRRHLPFAFKPVVEDS 309
            .:..|:.  .|..|.||::|..:..::   |....|...:|.....|          |.|..:..
Worm   272 CKEFAQF--QGYTGTDSQSLFDWYMAQNVSKFKEVAGFQSTAAGAVP----------FIPNFDGD 324

  Fly   310 SSPDRFLEQDIMEL-MHKKDCLGSMPVIMGYNSAEGLAIVVKAKQKLEAYEDDLARLVPRNLVLD 373
            ..|..|   ||:.. ..|||.|  :.|:    :.|.:.:::.......||.:.      ...:.:
Worm   325 FFPKPF---DILRREAPKKDAL--ITVV----TMESVGMIIFNPLFANAYNNF------EGFINE 374

  Fly   374 PQAPEAQEAASDIR----AFFFNGQALSKENMDN--LVDLFSDYHFSMDLQRAVEIHASCQTQSP 432
            ...|:..:..:|::    .|:......|.:...|  :||..||..|:.....||:.:..
Worm   375 TYGPDVTDYYADVKKKLTGFYLKDVNASDKATVNRRVVDYVSDSVFNSGTLDAVKSYVK------ 433

  Fly   433 LYFYRLDYVGGRNLYKKIFQN-----EDLRGVAHADDICYLF------QMAGDETEMNRDDLMVT 486
             |..:: |:|..|.:....::     :..:..:|:.|..|.|      .....:.||...|:..|
Worm   434 -YGNKV-YLGSFNYFNDATKDMVELMQPFKEASHSSDFKYYFGSGVMANFTPTDEEMEVMDMSGT 496

  Fly   487 ERLCEMWANFARDGKPS------PIWKP--VKKPH 513
                 :.|||.:.|.|:      | |||  :.||:
Worm   497 -----LMANFVKYGDPNGKSGTKP-WKPYTILKPN 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	151/534 (28%)
cest-30	NP_504407.1	COesterase	31..539	CDD:278561	155/555 (28%)
cest-30	NP_504407.1	Aes	<122..>230	CDD:223730	55/107 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820