DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment clt and cest-13

DIOPT Version :9

Sequence 1:NP_536784.1 Gene:clt / 117300 FlyBaseID:FBgn0000326 Length:562 Species:Drosophila melanogaster
Sequence 2:NP_741921.1 Gene:cest-13 / 181493 WormBaseID:WBGene00010116 Length:548 Species:Caenorhabditis elegans


Alignment Length:543 Identity:141/543 - (25%)
Similarity:233/543 - (42%) Gaps:102/543 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 VNGLEY---NSFLGVPYAEPPVGELRFRSPRPLERFQKQELDCSKEGNVSYQRDPFTLEVAGSED 98
            :.|:::   .||.|:.||:||||..||.:.|.|:....  ::....||:..|.|..|    ..||
 Worm    36 IRGIQHTYGTSFRGIRYAQPPVGLFRFGAARRLDPVGL--VEAQAYGNICVQGDGRT----SHED 94

  Fly    99 CLFLNVYAPKVKSTRTPLPVMVWIHGGGFFFGNGNSDFH-FPAKLMEQEVIVVTLNYRLGALGFL 162
            |||:|||.|...:..:.|||.|:||||||..|.||.... :|..:.:..:::|::|||||..||.
 Worm    95 CLFINVYTPNNVTQASKLPVYVYIHGGGFVEGGGNMGAGIYPNLVNKGPIVMVSINYRLGPFGFF 159

  Fly   163 SLPEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAGGSSVHLHTFARHAKRLFHKA 227
            |..:....||..:.|...||.|||..|:.|.||||.||:.|:|:|..:|...|....||.||.::
 Worm   160 STRQMTAPGNWAISDWIEALNWVQRYISFFGGDPNRVTIGGQSSGAEAVSTLTLTPLAKNLFKQS 224

  Fly   228 IMQSGTANMEWV--FQNEAPAKTRRLAELLG---------GGDFGGDSKALLTFLQSEKATPTAI 281
            |.:||:|....|  :..:..:.:::|:..||         |..||    .:||.|::........
 Worm   225 IHESGSAFGAAVMSYSEKTRSTSKQLSIKLGCATSDQWDNGQSFG----TILTCLRNVTYDKIVA 285

  Fly   282 LANTLKVLSPDERRRHLPFAFKPVVEDSSSPDRFLEQDIMELMHKKDCLGSMPVIMG-------- 338
            ..|:|    |..|.:.      .:|:|    :::|.|.:..|..::|  ....|::|        
 Worm   286 ADNSL----PGHRMKW------SIVQD----NKYLTQRLEYLALQRD--PKKNVLIGDVHDEWLG 334

  Fly   339 -------------YNSAEGLAIVVKAKQKLEAYEDDLARLVPRNLVLDPQAPEAQEAASDIRAFF 390
                         :|:|..:...:....::..:::..:.||                |:|.:  :
 Worm   335 WEMNNVLHNINSSHNTAHQMRDDLSGSYEMTYWDNKQSVLV----------------AADNK--Y 381

  Fly   391 FNGQALSKEN----MDNLVDLFSDYHF-SMDLQRAVEIHASCQTQSPLYFYRLDYVGGRNLYKKI 450
            .|.|..:.:|    ....:.|:|:..| ...|:.|....   ..::.:|.|.||::....|  .:
 Worm   382 INNQGWTDDNHREWEARRIQLWSEMVFIGPTLRDAAYFQ---YMKNNVYLYSLDWLSPPAL--PL 441

  Fly   451 FQNEDLRGVAHADDICYLFQMAGDETEMNRDDLMVTERLCEMWANFARDGKPSPIWKPVKKPHNG 515
            ..:...||..|..::.|:|..:.:.......|.::.......|.||...|.|:|.         |
 Worm   442 VTDPLFRGCEHTWELQYIFSTSCNGFTCTAQDEILRNYFTTTWLNFIIGGNPTPA---------G 497

  Fly   516 EPIQLDCLLID---RELKMCSNP 535
            .|:....|.:|   |.|....||
 Worm   498 SPLPFKWLAMDSTNRFLSFSPNP 520

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cltNP_536784.1 COesterase 22..543 CDD:278561 141/543 (26%)
cest-13NP_741921.1 Abhydrolase 22..510 CDD:304388 137/531 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000017
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11559
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.100

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