Protein Alignment clt and cest-1.1

DIOPT Version :10

• Sequence 1: NP_536784.1
• Gene: clt / 117300
• FlyBaseID: FBgn0000326
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_506506.1
• Gene: cest-1.1 / 179915
• WormBaseID: WBGene00011362
• Length: 673
• Species: Caenorhabditis elegans
• Alignment Length: 638
• Identity: 141/638 - (22%)
• Similarity: 240/638 - (37%)
• Gaps: 179/638 - (28%)

  Fly     2 LLRPCGRLIFTRF--CSSMKVKVPVKQGVLVGRQKKLVNGLEYNS--------FLGVPYAEPPVG 56
            :|:|...|:..:.  |.    :|.:..|.:.|   |::| :.|:.        |||:|:.|||:|
 Worm     1 MLKPATVLLLIQMYVCK----RVQLSSGTIEG---KILN-ISYSPLGNQSATVFLGIPFVEPPIG 57

  Fly    57 ELRFRSPRPLERFQ------KQELDCSKEGNVSYQRDPFTLEVAG--SEDCLFLNVYAPKVKSTR 113
            :||:|.|||.:.::      :.:..|......:|:.     :..|  |||||:|||...:.....
 Worm    58 DLRYRKPRPPKSWEGVLVTNEYKSACMSNATKTYKN-----KFGGPISEDCLYLNVLTNEYCLEN 117

  Fly   114 TPLPVMVWIHGGGF----------------FFGNGNSDFHFPAKLMEQEVIVVTLNYRLGALGFL 162
            ....||:.:||||:                |.|.|            :.::|||.|||||...|.
 Worm   118 KNCSVMMIVHGGGYLTESASTFNPEILINNFVGQG------------RNIVVVTFNYRLGLFSFG 170

  Fly   163 SLPEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAGGSSVHLHTFARHAKRLFHKA 227
            ....:....|.||.|...::.||:..|.:|.|:.|.:||.|.|||.|.:...|.:...|.|.|:.
 Worm   171 QFNGDRGDKNFGLYDMIESVNWVRREIENFGGNKNRITLAGHSAGASMIVAFTSSPLTKGLVHQQ 235

  Fly   228 IMQSGTANMEWVFQNEAPAKTRRLAELLGGGDFGGDSKALLTFLQSEKATPTAILANTLKVLSPD 292
            |:.|            ||     :..:....:|.|                ..::|..:..||.:
 Worm   236 IIMS------------AP-----MTNMSKKSNFKG----------------MTVMAQMVGCLSEE 267

  Fly   293 ERRRHLPFAFKPVVED----------SSSPDRFLEQDIMELMHKKDCLGSMPVIMGYNSAEGLAI 347
                   ..|..:.|:          ..|..:.|:..:..|.:....||:.|:
 Worm   268 -------IGFNKLSEEQVENTYSCLRKKSAQQILDAQLWLLQNSTYFLGAPPI------------ 313

  Fly   348 VVKAKQKLEAYEDDL---ARLVPRNLVLDPQAPEAQEAASDIRAFFFNGQALSKENMDNLVD--- 406
               .:..|..|.::|   ..:.|.|.::.....|.:|::..|...|.:.:.   |.::||.|
 Worm   314 ---DEHFLTDYPENLYASKSIYPINTLIGTTTLEVEESSYIIDPAFADKKV---ELLENLCDHIG 372

  Fly   407 ----------------LFSDYHFSMDLQRAVEI----------HASCQTQSPLYFYRLDYVGGRN 445
                            .:.:.:.||:|...:|.          |.|..|:..||.|  ||.|...
 Worm   373 YVLYEEPETFSKKCQKQYMNGNSSMNLSNEMEFYTPAIDFADSHTSGNTKVFLYSY--DYRGAGP 435

  Fly   446 LYKKIFQNEDLRGVAHADDICYLFQMAGDETEMNRDDLMVTERLCE-MWANFARDGKPSPI---- 505
            .|.:..   ::|...|::|:.|:|   |....:......:.|::.. |:|:|.....|.|.
 Worm   436 AYDRYL---EVRSPHHSEDLIYVF---GTHRGIFAPKDYIIEKIYSGMFADFVNFENPLPSGDQK 494

  Fly   506 WKPVKKPHNGEPIQLDCLLIDREL---KMCSNPDGERMDFWRSMYRRYRSENF 555
            |....| .|.|...::   .|:..   .|..|...|..:||.::.::...|.:
 Worm   495 WNQYTK-ENREHFLIN---FDKNFITPGMRDNYYTEAYEFWSTVGKKSFKEEW 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	alpha/beta hydrolases	22..543	CDD:473884	134/602 (22%)
cest-1.1	NP_506506.1	COesterase	19..531	CDD:395084	134/602 (22%)