Protein Alignment clt and cest-1.2

DIOPT Version :10

• Sequence 1: NP_536784.1
• Gene: clt / 117300
• FlyBaseID: FBgn0000326
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_506504.2
• Gene: cest-1.2 / 179914
• WormBaseID: WBGene00011364
• Length: 676
• Species: Caenorhabditis elegans
• Alignment Length: 573
• Identity: 145/573 - (25%)
• Similarity: 234/573 - (40%)
• Gaps: 98/573 - (17%)

  Fly    17 SMKVKVPVKQGVLVGRQKKLVNGLEYN----SFLGVPYAEPPVGELRFRSPRPLERF------QK 71
            ::..||.:..|::.|:|.........|    :|||:||.|||:|:||||.|||.:.:      :|
 Worm    16 AISTKVQLSTGIIEGKQLNSTYSPFGNQSAIAFLGIPYVEPPIGDLRFRKPRPQKTWSGVLETKK 80

  Fly    72 QELDCSKEGNVSYQRDPFTLEVAG--SEDCLFLNVYAPKVKSTRTPLPVMVWIHGGGFFFGNGNS 134
            .:..|......:|:..    .:.|  |||||:|||...:.........|::.:||||:.|.:..:
 Worm    81 FKPACMSNSTKTYKNG----GIGGPISEDCLYLNVLTNQYCLENKNCSVVIIVHGGGYLFESAAT 141

  Fly   135 DFH------FPAKLMEQEVIVVTLNYRLGALGFLSLPEEGIHG--NMGLKDQRLALEWVQENIAS 191
            ..|      |..:  ::.::|||:|||||..||..|  .|..|  |:|:.|...|::||:..|..
 Worm   142 FNHEILVNNFVGQ--DRNIVVVTINYRLGIFGFGHL--NGFEGDKNVGIFDTLEAVKWVRREIKQ 202

  Fly   192 FNGDPNNVTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSG--------------TANMEWVFQN 242
            |.|:.:.:||.|.|||...|...|.:...|.|.|:.|:.||              ||..|.|..:
 Worm   203 FGGNKDRITLAGHSAGAGVVAAFTISPLTKGLIHQQIVMSGPMTNMSKKSNFKGMTAMAERVGCH 267

  Fly   243 EAPAKTRRLAELLGGGDFGGDSKALLTFLQSEKATPTAILANTLKVLSPDERRRHLPFAFKPVVE 307
            .......:|.|        .:.:.:.:.|:.:.|  ..:|...|.:|    :.....|...||
 Worm   268 SKKYGFNKLPE--------HEVEQVYSCLRKKPA--QELLDAQLWLL----QNSTFYFGAPPV-- 316

  Fly   308 DSSSPDRFLEQDIMELMHKKDCLGSMPVIMGYNSAE----GLAIVVKAKQKLEAYEDDLARLVPR 368
                 |.....|..:.::.:..:.|:..::|..:.|    |. |......|.|..|..|..|..:
 Worm   317 -----DGEFITDYPDNLYSEKSIFSINTLLGTTTRELQDTGY-ISNSNYSKFETKETFLKNLCDQ 375

  Fly   369 NLVLDPQAPEAQEAASDIRAFFFNGQALSKENMDNLVDLFSDYHFSMDLQRAVEIHASCQTQSPL 433
              :......|:::.:|..:.::.||.. ||       .|..|..|........:.||  :....:
 Worm   376 --IGIEIYKESEDFSSKCQKWYINGSD-SK-------SLSDDMEFYTQAINLADAHA--RKGKKV 428

  Fly   434 YFYRLDYVGGRNLYKKIFQNEDLRGVAHADDICYLFQMAGDETEMNRDDLMVTERLCE-MWANFA 497
            |.|...|.|....:||..:   ::...|::|:.|.|   |....:......|.|.:.. |:|:|.
 Worm   429 YMYSYAYSGAGPAFKKYMK---VKSPHHSEDLIYTF---GTHRGVFAPKDYVIEYIYSGMFADFI 487

  Fly   498 RDGKPSPI----WKPVKKPHNGEPIQLDCLLIDRELK---MCSNPDGERMDFW 543
            ....|||.    |....| .|.|...:|   .|:.|.   |..|...:..:||
 Worm   488 NFEDPSPSTDQPWLQYTK-ENKEYFLVD---FDQNLTMPGMKKNYYAKAYEFW 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	alpha/beta hydrolases	22..543	CDD:473884	142/566 (25%)
cest-1.2	NP_506504.2	COesterase	18..536	CDD:395084	143/569 (25%)