DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clt and cest-17

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_505114.1	Gene:	cest-17 / 179198	WormBaseID:	WBGene00019477	Length:	571	Species:	Caenorhabditis elegans

Alignment Length:	581	Identity:	160/581 - (27%)
Similarity:	249/581 - (42%)	Gaps:	65/581 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LIFTRFCSSMKVKVPVKQGVLVG-RQKKLVNGLEYNSFLGVPYAEPPVGELRFRSPRPLERFQKQ 72
            |:...||.| |.||....|.:|| ..|..|.|.:|:.|||:.|..||....||:.|.|:|::...
Worm    12 LVSPAFCVS-KPKVTTPYGPIVGFEHKSTVTGSKYHVFLGIRYGNPPDHIYRFQKPEPVEKWPHI 75

  Fly    73 ELDCS--KEGNVSYQRDPFTLEVAGSEDCLFLNVYAPKVKSTRTPLPVMVWIHGGGFFFGNGNSD 135
            ..|.:  :...:...|.....:|..||||||||:..|. .:....|||:|:||||||.||:.:..
Worm    76 NHDATHFRASCIPSLRSELEEQVNYSEDCLFLNIVTPP-DAKEKKLPVLVFIHGGGFQFGDTSMI 139

  Fly   136 FHFPA--KLMEQEVIVVTLNYRLGALGFLSLPEEGIHGNMGLKDQRLALEWVQENIASFNGDPNN 198
            .:..|  ..:.:::|.|::.||||.|||.:..:..|.|||||.||.|||:::.|.:..|.|||:.
Worm   140 GYQKAADNFVSKDIIFVSIQYRLGPLGFFTTGDSEIPGNMGLWDQTLALQFLHEVLPDFGGDPDR 204

  Fly   199 VTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEWVFQNEAPAKTRRLAELLGGGDFGGD 263
            :||.|.|||.:||....::.|:..||.:||..||:...|..........:|:||:..|...  .|
Worm   205 ITLAGHSAGAASVSALLYSPHSDHLFSQAIQLSGSIFSESNLDRNVVDDSRKLAKAAGCPQ--ED 267

  Fly   264 SKALLTFLQSEKATPTAILANTLKVLSPDERRRHLPFAFKPVVEDSSSPDRFLEQDIMELMHKKD 328
            ||.|...::............::..|.|..|.:    .|.|..:..     |...||.::..|..
Worm   268 SKELRDCIEIRTVDELLDAMESIGELLPGPRTK----KFHPYFDKD-----FFPYDIEKMSRKAP 323

  Fly   329 CLGSMPVIMGYNSAEGLAIVVK-------AKQKLEAY-EDDLARLVPRNLVLDPQAPEAQEAASD 385
            ...:|..::...|...:...||       .|:....| :|:|...:...:.::.:...|....|.
Worm   324 KKRTMQGLVSLESGLSVLYPVKLAKLLGVPKESWSTYSKDNLVDFIRSQVAVEQEFGTASARFSG 388

  Fly   386 -IRAFFFNGQALSKEN--MDNLVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFYRLDYVGGRNLY 447
             :..|:.:|......:  ::...:|.||..:::.....||:  ..|.....|.|.:||
Worm   389 LVEEFYLSGPMTGNSSFYLNAFANLLSDLQYNIPTLHEVEL--KLQHGWDTYLYIIDY------- 444

  Fly   448 KKIFQNE-------DLRGVAHADDICYLFQMAG-DETEMNRDDLMVTERLCEMWANFARDGKPSP 504
                .:|       .::|..||.::.|||...| |....|..|............||...|.||.
Worm   445 ----DSETTKDPTHPIKGPFHASELRYLFNFNGMDTIPFNDKDKKFENYFVNAIVNFINTGTPST 505

  Fly   505 ---IWKPVKKPHNGEPIQLDCLLIDRELKMCSNPDGERMDFWRSMYRRYRSENFEAVRAKL 562
               :|..|.|   .:|. .:.||.|:.....|        |.:..|..::|:..:.|.|.|
Worm   506 KALLWPAVSK---SQPF-ANLLLNDKPSVQTS--------FRQEAYELWQSDIAKTVGADL 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	148/547 (27%)
cest-17	NP_505114.1	COesterase	20..542	CDD:278561	153/559 (27%)
cest-17	NP_505114.1	Aes	<109..>225	CDD:223730	47/116 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920