Protein Alignment clt and cest-33

DIOPT Version :10

• Sequence 1: NP_536784.1
• Gene: clt / 117300
• FlyBaseID: FBgn0000326
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_504621.1
• Gene: cest-33 / 179020
• WormBaseID: WBGene00017431
• Length: 554
• Species: Caenorhabditis elegans
• Alignment Length: 603
• Identity: 167/603 - (27%)
• Similarity: 259/603 - (42%)
• Gaps: 147/603 - (24%)

  Fly    23 PVKQGVLVGRQKKLVNGLEYNSFLGVPYAEPPVGELRFRSPRPLERFQKQELDCSKEGNVSYQRD 87
            ||: |.:......:|:|     :||:|||:||||||||:.|..::.:.:.: ||.|.|....|..
 Worm    23 PVR-GNIYKHDDVIVDG-----YLGIPYAKPPVGELRFKKPVTVDVWTEIK-DCYKYGPACVQTG 80

  Fly    88 PF---------TLEVAGSEDCLFLNVYAPKVKST--RTPLPVMVWIHGGGFFFGNGNSDF---HF 138
            .|         |.|.||   ||.|||:.|:..|:  :...||||:|||||:.. ..:|||   ..
 Worm    81 GFEQIAGPRTPTPEEAG---CLTLNVFTPRNASSEFKNGRPVMVYIHGGGYEL-CASSDFCAYSL 141

  Fly   139 PAKLMEQEVIVVTLNYRLGALGFLSLPEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFG 203
            ...|..::|:||::|||||..|||:..:....||.||.||.|||:|||::|:||.||||.||:||
 Worm   142 SGTLPLKDVVVVSINYRLGVFGFLTTGDNVCPGNFGLWDQTLALKWVQKHISSFGGDPNCVTVFG 206

  Fly   204 ESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEWVFQ-NEAPAKT-RRLAELLGGGDFGG-DSK 265
            :||||:|..|.:.:.|::.||.:.|..||||:.::..: :|..||. |..||..|   |.| ||.
 Worm   207 QSAGGASTDLLSLSPHSRDLFQRFIPISGTAHCDFAIRASENQAKIFREFAEFHG---FSGRDSS 268

  Fly   266 ALLTFLQSEKATPTAILANTLKVLSP-----------------DERRRHLPFAFKPVVEDSSSPD 313
            ||..:.|.:.....:.:....|.:|.                 ||.|:..|
 Worm   269 ALFKWYQEQSPETLSNVKGYKKSISGFLTFIPNLDGDFFPKPLDELRKEAP-------------- 319

  Fly   314 RFLEQDIMELMHKKDCLGSMPVIMGYNSAEGLAIVVKAKQKLEAYEDDLARLVPR------NLVL 372
                        ||.      ::.|....|||.               ||.:.|.      .|.|
 Worm   320 ------------KKQ------MMTGVTEYEGLM---------------LASMNPAFSPADVGLTL 351

  Fly   373 DPQAPEAQEAAS---DIRAFFFNGQALSKENMDNLV------DLFSDYHFSMDLQRAVEIHASCQ 428
            .||....::..|   :|:..|:.......:..|.|.      :...|..|::.:.:|.:  .:.:
 Worm   352 MPQGIYGKDVVSNPDEIQKIFYEKYVEGVDKSDELAMRKKLCEALGDEFFNVGVIQAAK--NAAK 414

  Fly   429 TQSPLYFYRLDYVGGRNLYKKIFQNED----------LRGVAHADDICYLF-QMAGDETEMNRDD 482
            ..:.:|||..:||           |.|          .:...|..::.||. :....:.|...:|
 Worm   415 HGNEVYFYTFEYV-----------NPDSFGMWDGMMPFKAAVHCTELRYLLGEGVYSKFEPTEED 468

  Fly   483 LMVTERLCEMWANFARDGKP------SPIWK--PVKKPHNGEPIQL-DCLLID----RELKMCSN 534
            ..|.|....:::|||:.|.|      :.||:  .:.:|.....|.. .|.:.|    ..::....
 Worm   469 RKVMETTTTLFSNFAKYGNPNGKGATAEIWEKYSLNRPERHYRISYPKCEMRDVYHEGRIQFLEK 533

  Fly   535 PDGERMDFWRSMYRRYRS 552
            .||:...:...:|.:.:|
 Worm   534 IDGDSDKYQELVYGKKKS 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	alpha/beta hydrolases	22..543	CDD:473884	165/592 (28%)
cest-33	NP_504621.1	Esterase_lipase	16..521	CDD:238191	162/571 (28%)