DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clt and cest-35.1

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_504400.1	Gene:	cest-35.1 / 178912	WormBaseID:	WBGene00015067	Length:	545	Species:	Caenorhabditis elegans

Alignment Length:	565	Identity:	160/565 - (28%)
Similarity:	247/565 - (43%)	Gaps:	126/565 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PVKQGVLVGRQKKLVNGLEYNSFLGVPYAEPPVGELRFRSPRPLERFQKQELDCSKEGNVSYQRD 87
            |:: |.:.....|:|:|     :||:|:|:.|:|||||:.....|:: .:.|||.|.|....|..
Worm    23 PIR-GNIYEHDDKIVDG-----YLGIPFAKAPIGELRFKKSVEAEKW-TEPLDCYKYGPGCPQSG 80

  Fly    88 PF---------TLEVAGSEDCLFLNVYAPKVKSTRTP--LPVMVWIHGGGFFFGNGN--SDFHFP 139
            ..         .:.....::||.|||:|||.||...|  |||:|:.:||||..|..:  .|:...
Worm    81 ALGAMIVPQASAIREFAEDNCLTLNVFAPKWKSAEFPNGLPVIVYFYGGGFEVGFSSMFDDYSLT 145

  Fly   140 AKLMEQEVIVVTLNYRLGALGFLSLPEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGE 204
            ..|..::||:||.|||:|.|||.:..::...||.||.||.|||:|||::|.||.|||:|||:.|.
Worm   146 GTLPLKDVILVTPNYRIGPLGFFATGDDVSRGNWGLWDQALALQWVQKHIKSFGGDPSNVTISGT 210

  Fly   205 SAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEW----------VFQNEAPAKTRRLAELLGGGD 259
            ||||:||...:.:.||.:.|||.|..||.|...:          :|:..|...          |.
Worm   211 SAGGASVDFLSLSPHANKYFHKFIPMSGAATCPFGIRSKDVEGLIFREFAKHH----------GY 265

  Fly   260 FGGDSKALLTFLQSEKATPTAILANTLKVLSPDERRRHLP----FAFKPVVEDSSSPDRFLEQDI 320
            .|.||::||.:.||:.|          ::....|..:: |    |:|.|..:....|..|  .::
Worm   266 AGNDSESLLHWYQSQDA----------EIFLKAEGFKY-PASGMFSFVPNYDGDFFPKPF--DEL 317

  Fly   321 MELMHKKDCLGSMPVIMGYNSAEGLAIVVKAKQKLEAYEDDLARLVPRNLVLDPQAPEA-----Q 380
            .:...|.|.:.|:.      ..|||...       |.|....:   |:.::.....||.     :
Worm   318 RKEAPKLDAIVSVA------EYEGLGFE-------EFYPGQKS---PQEVLTAALGPEVVRNREE 366

  Fly   381 EAASDIRAFFFN-----GQALSKENMDNLVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFYRLDY 440
            .....:.|:..|     |:.:.|:    ||::|.||:||:.:...|...|..
Worm   367 VVKKAVEAYLENIEDKSGEKIGKK----LVEIFGDYYFSVGVFDTVRSLAKY------------- 414

  Fly   441 VGGRNLYKKIF------------QNEDLRGVAHADDICYLFQMAGDET-EMNRDDLMVTERLCEM 492
              |.|:|...|            :|......:|..||.|:.   ||.. |.:::|..|.:.:...
Worm   415 --GNNVYLSSFNYFNPETPIMFGENRPFNAASHGCDIRYIL---GDGIGEFSKEDRKVMDMMGTY 474

  Fly   493 WANFARDGKP-----SPIWKPVKKPHNGEPIQLD---CLLIDREL 529
            ..|||:.|.|     |..|:.....:.|...::|   |.:.|..|
Worm   475 LTNFAKYGNPNGKGVSIPWEKYSLDNPGRYFKIDYPKCEMADNFL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	160/565 (28%)
cest-35.1	NP_504400.1	COesterase	14..516	CDD:278561	158/560 (28%)
cest-35.1	NP_504400.1	Aes	<106..>214	CDD:223730	53/107 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820