DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clt and cest-35.2

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_504398.1	Gene:	cest-35.2 / 178910	WormBaseID:	WBGene00016863	Length:	544	Species:	Caenorhabditis elegans

Alignment Length:	568	Identity:	169/568 - (29%)
Similarity:	258/568 - (45%)	Gaps:	113/568 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IFTRFCSSMKVKVPVKQGVLVGRQKKLVNGLEYNSFLGVPYAEPPVGELRFRSPRPLERFQKQEL 74
            :|...|.      |:: |.:.....|:|||     :||:|:|:.|:|:|||:.....|:: .|.|
Worm    16 VFNASCG------PIR-GNVYEHGDKIVNG-----YLGIPFAKAPIGDLRFKKSVEAEKW-TQPL 67

  Fly    75 DCSKEGNVSYQRDPF-TLEVA-------GSEDCLFLNVYAPKVKSTRTP--LPVMVWIHGGGFFF 129
            ||.|.|....|.... .|.|:       ..::||.|||:|||.||...|  .||||:.:||||..
Worm    68 DCYKYGPGCPQSAALGALMVSQATNHDFAEDNCLNLNVFAPKWKSAEFPNGFPVMVYFYGGGFEV 132

  Fly   130 GNGN--SDFHFPAKLMEQEVIVVTLNYRLGALGFLSLPEEGIHGNMGLKDQRLALEWVQENIASF 192
            |..:  .|:.....|..::||:||.|||:|.|||.:..::...||.||.||.|||:|||::|.||
Worm   133 GFSSMFDDYSLTGTLPLKDVILVTPNYRIGPLGFFATGDDVARGNWGLWDQALALQWVQKHIKSF 197

  Fly   193 NGDPNNVTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEW----------VFQNEAPAK 247
            .|||:|||:.|.||||:||...:.:.||.:.|.|.|..||.|...:          :|:..|...
Worm   198 GGDPSNVTISGTSAGGASVDFLSLSPHANKYFQKFIPMSGAATCPFGIRSKDVEGLIFREFANHH 262

  Fly   248 TRRLAELLGGGDFGGDSKALLTFLQSE------KATPTAILANTLKVLSPDERRRHLPFAFKPVV 306
                      |..|.|||:||.:.||:      ||......|:.:             |:|.|..
Worm   263 ----------GYTGNDSKSLLQWYQSQDSEIFLKAEGYKCPASGM-------------FSFVPNF 304

  Fly   307 EDSSSPDRFLEQDIMELMHKKDCLGSMPVIMGYNSAEGLAIVVKAKQKLEAYEDDLA-RLVPRNL 370
            :....|..|     .||..:...||::..|..|   |||           .:||..| :..|:.:
Worm   305 DGDFFPKPF-----DELRKEAPKLGAIVSIGEY---EGL-----------GFEDFYAGQKTPQQM 350

  Fly   371 VLDPQAPEAQEAASDI-----RAFFFNGQALSKENM-DNLVDLFSDYHFSM---DLQRAVEIHAS 426
            :.....||......::     .::..||...::||: ..||::|.||:||:   |..|::..:.
Worm   351 LSAALGPEVVRNREEVVKRAAESYLKNGGNENEENIAKTLVEIFGDYYFSVGAFDTVRSLVKYG- 414

  Fly   427 CQTQSPLYFYRLDYVGGRNLYKKIF-QNEDLRGVAHADDICYLFQMAGDET-EMNRDDLMVTERL 489
                :.:|.|..:|.....  ..:| :|.......|..|:.|:|   |:.| |.:::|..|.:.:
Worm   415 ----NTVYLYSFNYFNPNT--PIVFGKNRPFNAANHGSDLRYIF---GEGTGEFSKEDRQVMDMM 470

  Fly   490 CEMWANFARDGKP-----SPIWKPVKKPHNGEPIQLD---CLLIDREL 529
            .....|||:.|.|     |..|:.....:.|...::|   |.:.|..|
Worm   471 GTYHTNFAKYGNPNGKGVSVPWEKYSLDNPGRYFKIDYPKCEMADNFL 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	167/556 (30%)
cest-35.2	NP_504398.1	COesterase	14..515	CDD:278561	167/563 (30%)
cest-35.2	NP_504398.1	Aes	<105..>239	CDD:223730	64/133 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820