DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clt and cest-32

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_504397.1	Gene:	cest-32 / 178909	WormBaseID:	WBGene00016862	Length:	545	Species:	Caenorhabditis elegans

Alignment Length:	606	Identity:	171/606 - (28%)
Similarity:	260/606 - (42%)	Gaps:	141/606 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FCSSMKVKVPVKQ-----GVLVG----RQKKLVNGLEYNSFLGVPYAEPPVGELRFRSPRPLERF 69
            |.|.:|.:..::.     |.::|    ...|:|||     :||:|:|:.|:.||||:.|...|::
Worm     4 FLSHLKPEASLEVLNASCGPVIGNIYRHDDKIVNG-----YLGIPFAKAPICELRFKKPVEAEKW 63

  Fly    70 QKQELDCSKEG--------NVSYQRDPFTLEVAGSEDCLFLNVYAPKVKSTRTP--LPVMVWIHG 124
            .| .|:|.|.|        .:|....|...|.| .::||.||::||..||...|  ||:||:.||
Worm    64 TK-PLNCHKYGPGCPQSGHMISNLLPPGYREFA-EDNCLNLNIFAPSWKSEEFPNGLPIMVYFHG 126

  Fly   125 GGFFFGNGN--SDFHFPAKLMEQEVIVVTLNYRLGALGFLSLPEEGIHGNMGLKDQRLALEWVQE 187
            |||..|..:  .|:.....|..::|||||.|||:|.|||::..:|...||.||.||.|||:||||
Worm   127 GGFEIGFSSMFDDYSLSGTLPLKDVIVVTANYRVGPLGFMTTGDEVSRGNYGLWDQTLALKWVQE 191

  Fly   188 NIASFNGDPNNVTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEW----------VFQN 242
            :|.||.|:||.||:.|.||||.|..|...:.|:.:|||:.:..||:|..|:          :|:|
Worm   192 HIKSFGGNPNIVTVCGTSAGGVSAGLLALSPHSNKLFHRFMAMSGSAFCEFSIRTKEQEAEIFRN 256

  Fly   243 EAPAKTRRLAELLGGGDFGGDSKALLTFLQSE---KATPTAILANTLKVLSPDERRRHLPFAFKP 304
            .|...          |..|.||::||.:.:|:   |...||..          |::......|.|
Worm   257 FAKHH----------GYEGEDSESLLEWYKSQPLSKFQETATF----------EKKASGFLTFIP 301

  Fly   305 VVEDSSSPDRFLEQDIMELMHKKDCLGSMPVIMGYNSAEGLAIVVKAKQKLEAYEDDLARLVPRN 369
            ..:....|..|     .||..:...|.:|..:..|.....|.:....:..::..:......|..|
Worm   302 NFDGDFFPKPF-----DELSREAPKLDAMATVDEYEGLGFLTMFQSRRNDMDIIKSSFGSDVVEN 361

  Fly   370 LVLDPQAPEAQEAASDIRAFFF------NGQALSKENMDNLVDLFSDYHFSMDLQRAVEIHASCQ 428
            .|         :....|..|:.      :.:|:.|    .|:.|.||..|::.....|:  .|.:
Worm   362 AV---------DVQKRIMEFYMKNIDKNDDKAVEK----RLIQLISDSWFNIGALETVK--TSTK 411

  Fly   429 TQSPLYFYRLDY--VGGRNLYKKIFQNEDLRGVAHADDICYLFQMAGD--------ETEMNRDDL 483
            ..|..|....||  :|..:.|...|   ..:...|..::.|   |.|:        |.|....|:
Worm   412 YGSNAYLGSFDYYNMGSNDPYATWF---PFKAANHGSELKY---MLGEGMGKFSPIEEEFKVIDM 470

  Fly   484 MVTERLCEMWANFARDGKPSPI-----WKPV--KKPHNGEPIQLDCLLIDRELKMCSNPDGERMD 541
            |.|     :.|||.:.|.|:.|     ||..  :||::                      ..::|
Worm   471 MGT-----LTANFVKYGNPNGINGPELWKKYTPEKPYS----------------------YFKID 508

  Fly   542 FWRSMYRRYRSENFEAVRAKL 562
            :.:|..|    :||:..|.||
Worm   509 YPKSEMR----DNFQDGRLKL 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	161/577 (28%)
cest-32	NP_504397.1	COesterase	15..516	CDD:278561	163/584 (28%)
cest-32	NP_504397.1	Aes	<104..>227	CDD:223730	59/122 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810