Protein Alignment clt and cest-4

DIOPT Version :10

• Sequence 1: NP_536784.1
• Gene: clt / 117300
• FlyBaseID: FBgn0000326
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_501043.1
• Gene: cest-4 / 177445
• WormBaseID: WBGene00015930
• Length: 592
• Species: Caenorhabditis elegans
• Alignment Length: 557
• Identity: 118/557 - (21%)
• Similarity: 200/557 - (35%)
• Gaps: 150/557 - (26%)

  Fly     1 MLLRP---CGRLIFTRFCSSMKVKVPVKQGVLVGRQKKLVNGLEYNS---FLGVPYAEPPVGELR 59
            |||.|   ...|:|..|.    :...:.:..:|......::|.:..|   |..:|.|:||:|:||
 Worm     1 MLLLPGLMNNLLLFLSFF----LLFSITKSAIVSTSLGQIDGDQIGSFHLFKHIPLAKPPIGKLR 61

  Fly    60 FRSPRPLERF------QKQELDCSKEGNVSYQRDPFTLEVAGSEDCLFLNVYAPKVKSTRTPLPV 118
            |:.|.|.|::      :.....|....:||.....:.     .||||.:|::............|
 Worm    62 FQKPEPPEKWTGVRNAKAYGPACISNSSVSTSPQKWI-----DEDCLHINIFTSDKCLKSKDCAV 121

  Fly   119 MVWIHGGGFFFGNG--NSDFHFPAKLMEQEVIVVTLNYRLGALGFLSLPEEGI-HGNMGLKDQRL 180
            :.:.||||..:.:.  .:|.:.....:.|:||:....:|||......:.::.| ..|:.|.|..|
 Worm   122 VTYFHGGGLMYDSAVMFNDTYLLGTFVNQDVIIAIPAFRLGIFSHFVVEDQSIAPTNLALYDILL 186

  Fly   181 ALEWVQENIASFNGDPNNVTLFGESAGGSSVHLHTFA---RHAKRLFHKAIMQSGTANMEWV-FQ 241
            .:|:|:..|.:|.|:....|:.|.|.|||.|::.||:   .|...||.::|..|...:.|.: .|
 Worm   187 GVEFVKNEIHNFGGNNQKNTIMGHSYGGSIVNILTFSSKINHDLSLFQQSICMSSGHDFETLEIQ 251

  Fly   242 NEAPAKTRRLAELLGGGDFGGDSKALLTFLQSEKATPTAILANTLKVLSPDERRRHLPFAFKPVV 306
            .:   ||.|.|:..|                   .|..:|:...:.....|..|
 Worm   252 IQ---KTNRFAKHAG-------------------CTVPSIIEKKMTTRQSDLYR----------- 283

  Fly   307 EDSSSPDRFLEQDIMELMHKKDCLGSMPVIMGYNSAEGLAIVVKAKQKL---EAY--------ED 360
                          |:.:..||.|..:.|                 |:|   |.|        .:
 Worm   284 --------------MKCLQNKDALELLRV-----------------QRLLEDEGYPTYGYLVQRE 317

  Fly   361 DLARLVPRNLVLDPQAPEAQEAASDIRAFFFN--------GQALSKENMDNLVDLF--------- 408
            .|.:.:|....:  ::|:.....:....:..:        ||||..||.:.:...|
 Worm   318 PLIQEIPYQEFM--KSPKKIPMLTGCTRYEMDHSPAPKPIGQALGFENPEEVYMKFRKDWDDEVY 380

  Fly   409 -----SDYHFSMDLQRAVEIHASCQTQSPLYFYRLDYVGGRNLYKKIFQNEDLRGVAHADDICYL 468
                 ||...::.:|..|.::.......|.|.|...|.               :...|.||:.||
 Worm   381 EFGNHSDETQAIMVQVRVRVNNLLSKNVPAYLYEYTYP---------------KHARHTDDLFYL 430

  Fly   469 F---QMAGDETEMNRDDLMVTERLCEMWANFARDGKP 502
            .   :...||.|:....:..|     ::.|||:.|.|
 Worm   431 MGVHRFEKDENEIELGKVYET-----IFMNFAKFGDP 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	alpha/beta hydrolases	22..543	CDD:473884	111/533 (21%)
cest-4	NP_501043.1	alpha/beta hydrolases	26..503	CDD:473884	111/528 (21%)